X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug designArticle Published on 2017-01-122022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] activity catalytic catalytic function cellular changes in core coronavirus Critical domain drug design Efficiency enzyme Enzymes evaluate Hypothesis in viral in vitro Infection inhibitor interferon MERS N-terminal N-terminus no difference Papain-like protease platform PLPro polyprotein polyproteins profile protease Proteins Regulation required specificity stability Structure substrate thermal stability utility was determined while X-ray [DOI] 10.1038/srep40292 PMC 바로가기 [Article Type] Article
Regulation of kynurenine biosynthesis during influenza virus infectionEditorial Published on 2017-01-012023-06-23 Journal: The Febs Journal [Category] 신종인플루엔자, [키워드] host-pathogen interaction indoleamine-pyrrole 2,3-dioxygenase (IDO1) Influenza virus Innate immunity interferon [DOI] 10.1111/febs.13966 [Article Type] Editorial
The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus InfectionResearch Article Published on 2016-12-132022-10-29 Journal: mBio [Category] Coronavirus, MERS, [키워드] abrogate acute respiratory syndrome ADP-ribose ADP-ribosylation antiviral property Cell culture changes in conserved coronavirus Coronavirus infection CoVs disease domain elicited enzyme epithelial cell line help highly pathogenic human CoV IFN Impact in viral in vitro Inclusion Infection Innate innate immune response Innate immunity interferon interferon-stimulated gene ISG lethal disease macrodomain mechanism mice Modification mutant virus Mutation mutations nonstructural protein 3 Nsp3 Pathogenesis positive-sense Proinflammatory cytokine promote PROTECT Protein protein targets Proteins reduced reducing reduction regulate Regulation Replication respiratory response RNA viruses SARS-CoV SARS-CoV infection strain suppressed target therapy understanding Viral load virulence virus virus attenuation [DOI] 10.1128/mBio.01721-16 PMC 바로가기 [Article Type] Research Article
Activating the innate immune response to counter chronic hepatitis B virus infectionReview Published on 2016-12-012023-06-18 Journal: Expert opinion on biological therapy [Category] B형 간염, [키워드] cccDNA Cytokines HBV Immunotherapy interferon toll like receptor [DOI] 10.1080/14712598.2016.1233962 [Article Type] Review
Hepatocellular carcinoma in children and young patients with chronic HBV infection and the usefulness of alpha‐fetoprotein assessmentOriginal Research Published on 2016-10-172023-06-03 Journal: Cancer Medicine [Category] B형 간염, [키워드] HBeAg seroconversion alpha‐fetoprotein Hepatocellular carcinoma interferon Liver cirrhosis [DOI] 10.1002/cam4.917 PMC 바로가기 [Article Type] Original Research
Original Research: Analysis of hepatic microRNA alterations in response to hepatitis B virus infection and pegylated interferon alpha-2a treatmentArticle Published on 2016-10-012023-06-18 Journal: Experimental Biology and Medicine [Category] B형 간염, [키워드] Hepatitis B virus interferon microRNA Next-generation sequencing [DOI] 10.1177/1535370216647184 PMC 바로가기
Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responsesResearch Published on 2016-09-072023-06-07 Journal: Respiratory Research [Category] Fulltext, 신종인플루엔자, [키워드] COPD HBEC Human Influenza Innate immunity interferon lung RIG-I TLR3 [DOI] 10.1186/s12931-016-0428-2 PMC 바로가기 [Article Type] Research
Treatment of HEV Infection in Patients with a Solid-Organ Transplant and Chronic HepatitisReview Published on 2016-08-152023-05-23 Journal: Viruses [Category] E형 간염, Fulltext, [키워드] hepatitis E immunosuppressants interferon ribavirin sustained virological response [DOI] 10.3390/v8080222 PMC 바로가기 [Article Type] Review
Gene Expression and Antiviral Activity of Interleukin-35 in Response to Influenza A Virus Infection *Article Published on 2016-08-052023-06-03 Journal: The Journal of Biological Chemistry [Category] B형 간염, [키워드] antiviral agent host defense host-pathogen interaction Influenza virus Innate immunity interferon interleukin NF-κB (NF-KB) viral infection [DOI] 10.1074/jbc.M115.693101 PMC 바로가기
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity비복제 Toxoplasma gondii Uracil Auxotrophs에 의한 Rhoptry 및 Dense Granule Effector 단백질의 분비는 항종양 면역의 발달을 제어합니다Research Article Published on 2016-07-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogated activate activated acute infection Auxotroph auxotrophic mutants axis CD4 CD8 Cell Nucleus Cell signaling cellular signaling pathway cellular signaling pathways conjunction Control deleted Deletion dendritic cells Dense development effective effective therapy effector effector molecule effector molecules effector protein effector proteins function Granule GTPase GTPases Host host cell host cell nucleus host cell response Host immune response host immune responses host innate immunity host response host responses identify IFN-γ immune responses Immune suppression Immunity independent Infection interferon Invasion latent infection mammalian cell mechanism membrane mice mutant not affect nucleus ovarian cancer parasite pathway Pathways Protein required responses rhoptry Safe secreted secretion shown Signaling solid tumor solid tumors survival T cell T cells target therapeutic These data Toxoplasma gondii transcriptional Trigger Tumor tumor microenvironment tumors type I uracil vaccination vaccine strain virulence [DOI] 10.1371/journal.pgen.1006189 PMC 바로가기 [Article Type] Research Article