Global Safety Database Summary of COVID-19-Related Drug Utilization-Safety Surveillance: A Sponsor’s PerspectiveCOVID-19 관련 약물 사용-안전 감시의 글로벌 안전 데이터베이스 요약: 후원자의 관점Observational Study Published on 2021-01-012022-09-11 Journal: Drug safety [Category] 임상, 치료제, [키워드] activity adverse event Antibiotics Anticoagulant Anticoagulants antimalarial association Azithromycin ceftriaxone characterized Chloroquine chloroquine/hydroxychloroquine Clinical data collected conditions coronavirus disease Coronavirus disease 2019 Corticosteroids COVID-19 COVID-19 case COVID-19 cases COVID-19 treatment database diarrhea Dictionary drug drug interaction electrocardiogram event events followed by Hepatitis Hydroxychloroquine Immunoglobulin immunomodulating agents Immunosuppressant immunosuppressive effect immunosuppressive effects include individual Infection interferons lAbel Lopinavir Lopinavir-ritonavir MedDRA off-label over Pfizer provide QT prolongation receiving reported retrospective Ritonavir Safety Seven subsequent Surveillance term therapeutic therapy Tofacitinib Torsade de Pointes treated treated patients Treatment unique were used [DOI] 10.1007/s40264-020-01035-x PMC 바로가기 [Article Type] Observational Study
Pharmacology and safety of tofacitinib in ulcerative colitis궤양성 대장염에서 토파시티닙의 약리학 및 안전성Review Published on 2021-01-012023-06-02 Journal: Gastroenterología y hepatología [Category] 대상포진, 두창, [키워드] Colitis ulcerosa Farmacología Jak Janus kinase Pharmacology Quinasas Janus Safety Seguridad Tofacitinib ulcerative colitis [DOI] 10.1016/j.gastrohep.2020.04.012 [Article Type] Review
Cellular pathology in the COVID-19 era: a European perspective on maintaining quality and safetyArticle Published on 2021-01-012023-06-19 Journal: Journal of Clinical Pathology [Category] MERS, SARS, [키워드] decontamination laboratory personnel Safety [DOI] 10.1136/jclinpath-2020-206789 PMC 바로가기
Safety profile of hydroxychloroquine and azithromycin combined treatment in COVID-19 patients코로나19 환자에서 하이드록시클로로퀸과 아지트로마이신 병용요법의 안전성 프로파일Article Published on 2021-01-012022-09-11 Journal: International journal of antimicrobial agents [Category] Coronavirus, 신약개발, 임상, 치료제, [키워드] combined treatment COVID-19 patient Hydroxychloroquine Safety [DOI] 10.1016/j.ijantimicag.2020.106236 PMC 바로가기 [Article Type] Article
Efficacy and Safety of Inhaled Ciclesonide in Treating Patients With Asymptomatic or Mild COVID-19 in the RACCO Trial: Protocol for a Multicenter, Open-label, Randomized Controlled TrialProtocol Published on 2020-12-312022-10-29 Journal: JMIR Research Protocols [Category] COVID-19, [키워드] administration antipyretics Baseline assessment changes in Ciclesonide clinical Clinical outcome conducted Controlled COVID-19 Data collection determine diagnosed with COVID-19 dose drug Drug administration effective Effectiveness Efficacy endpoint analysis enrolled exclusion criteria expected exploratory Fisher exact test follow-up assessment group groups hospital hypothese Identifier Inclusion Intervention investigator-initiated Japan Laboratory Limited multicenter objective Open-label parallel-group parameter participant Patient patients with COVID-19 peer-reviewed per day performed Pneumonia proposed therapy protocol Randomized Randomized controlled trial receive recruited reduction Registration registry report required Result Safe Safety SARS-CoV-2 statistically significant difference Symptomatic treatment Teijin therapeutic interventions therapeutic option therapy tomography treating Treatment treatment group Trial viral genome [DOI] 10.2196/23830 PMC 바로가기 [Article Type] Protocol
Safety, tolerability, and outcomes of losartan use in patients hospitalized with SARS-CoV-2 infection: A feasibility studyResearch Article Published on 2020-12-302022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Acute kidney injury adverse event AKI blockade Clinical outcome Cohort COVID-19 criteria de novo discharged Enrollment exclusion criteria feasibility hospital hospitalized patient hyperkalemia hypertension ICU admission include inclusion criteria Inflammatory marker inflammatory markers losartan maintain majority mechanical ventilation MOST Nasopharyngeal swab occurred outcome outcomes parameter Patient patients patients hospitalized PCR pilot study polymerase chain positive Prospective prospective cohort Prospective Study provide randomized clinical trials recruitment required retrospective retrospective cohort retrospective cohorts Safety SARS-CoV-2 screened significant changes in single center supplemental oxygen System Tolerability transaminitis with COVID-19 [DOI] 10.1371/journal.pone.0244708 PMC 바로가기 [Article Type] Research Article
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 VaccineClinical Trial Published on 2020-12-302022-10-04 Journal: The New England Journal of Medicine [Category] MERS, SARS, 임상, [키워드] 1:1 95% CI 95% confidence interval acute respiratory syndrome adverse event age Analysis Aside assigned authority baseline cause Complication complications conducted coronavirus coronavirus disease development Efficacy ENCODE enrolled Evidence first dose full-length spike protein high risk incidence infected with SARS-CoV-2 injection Injections Intramuscular injection Local mRNA-1273 mRNA-1273 vaccine mRNA-based vaccine observer-blinded occurred Older participant Participants Person Phase 3 Placebo placebo-controlled trial prefusion Prevent primary end point PROTECT Randomized Randomly reactogenicity receive Result Safety SARS-CoV-2 SARS-COV-2 infection Secondary analyses severe disease systemic reactions the placebo group The United States Trial two groups vaccination Vaccine virus Volunteer [DOI] 10.1056/NEJMoa2035389 PMC 바로가기 [Article Type] Clinical Trial
Occupational COVID-19 Prevention among Congolese Healthcare Workers: Knowledge, Practices, PPE Compliance, and Safety ImperativesArticle Published on 2020-12-302022-10-29 Journal: Tropical Medicine and Infectious Disease [Category] COVID-19, [키워드] 95%CI adjusted affected age approach assessment category conducted Contact Context COVID-19 COVID-19 epidemic COVID-19 symptoms COVID-19 vaccine cross-sectional Democratic Republic of the Congo disease transmission Government HCW HCWs health care workers health system healthcare worker hospital Infection prevention information knowledge majority Mask media Medical doctor occupational outbreak over pandemic participant Patient care patients Personal protective equipment positive attitude PPE prevention questionnaire receive Safety SARS-CoV-2 WHO’s World Health Organization’ [DOI] 10.3390/tropicalmed6010006 PMC 바로가기 [Article Type] Article
Safety of Newer Disease Modifying Therapies in Multiple SclerosisReview Published on 2020-12-262023-08-29 Journal: Vaccines [Category] E형 간염, [키워드] Disease modifying therapies Long-term outcomes multiple sclerosis Safety [DOI] 10.3390/vaccines9010012 PMC 바로가기 [Article Type] Review
Safety of ixekizumab in adult patients with plaque psoriasis, psoriatic arthritis and axial spondyloarthritis: data from 21 clinical trialsClinical Science Published on 2020-12-252024-09-04 Journal: Rheumatology (Oxford, England) [Category] 대상포진, [키워드] axial spondyloarthritis IL-17 Ixekizumab psoriasis psoriatic arthritis Safety [DOI] 10.1093/rheumatology/keaa189 PMC 바로가기 [Article Type] Clinical Science