The association between age and adverse events due to biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis A retrospective cohort studyarticle Published on 2020-12-242024-09-02 Journal: Molecular biology of the cell [Category] 대상포진, [키워드] Aged Biologic disease-modifying antirheumatic drugs drug therapy drug-related side effects and adverse reactions rheumatoid arthritis Safety [DOI] 10.1097/MD.0000000000023861 PMC 바로가기 [Article Type] article
Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trialResearch article Published on 2020-12-242022-10-05 Journal: EClinicalMedicine [Category] Coronavirus, 비임상, [키워드] administration adverse event Antigen binding binding antibody CD8+ T cell cellular cellular immune responses CEPI clinical trial Coalition COVID-19 Cytometry demonstrated described DNA vaccine ELISA ELISpot assay evaluated finding Flow Frequency full length funding geometric geometric mean titer Grade 1 groups humoral humoral immune response IC50 IL-4 immunogenic increase in Innovation INO-4800 median age men neutralizing antibody Open-label participant Participants PBMC Phase 1 preliminary report PRNT receiving reported response Safety SARS-CoV-2 second dose Serious Adverse Event seroconverted SFU subject T cell response the median TNF-α Tolerability Trial two group urgency Vaccine [DOI] 10.1016/j.eclinm.2020.100689 [Article Type] Research article
The long road to recovery: at six months since the first COVID-19 wave, elective orthopedic care has still not fully recovered in BelgiumOriginal Paper Published on 2020-12-212022-10-30 Journal: Journal of Experimental Orthopaedics [Category] COVID-19, [키워드] anaesthesia Arthroscopy Belgium Care Clinical practice Comorbidities Compliance COVID-19 COVID-19 guidelines COVID-19 testing decrease demographics Elective Elective care elective surgeries Elective surgery European evaluate First wave guideline had no Health implementation knee Knee surgery Level lockdown observé orthopaedic surgery orthopedic Outpatient visits Patient patient selection PCR test PCR testing Personal protective equipment PPE reported Result Safety Society sport supplementary material surgeon surgery Traumatology Volume [DOI] 10.1186/s40634-020-00316-9 PMC 바로가기 [Article Type] Original Paper
Perceived Effectiveness, Safety, and Attitudes Toward the Use of Nucleic Tests of SARS-CoV-2 Among Clinicians and General Public in China중국의 임상의와 일반 대중 사이에서 SARS-CoV-2의 핵 검사 사용에 대한 인식된 효과, 안전성 및 태도Public Health Published on 2020-12-172022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 All participant All participants approval Attitude biomedicine China Chinese Compliance conducted coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 cross-sectional cross-sectional study Efficacy Epidemic female IMPROVE knowledge Likert scale majority Novel coronavirus nucleic test pandemic participant Perceived positive positive attitude Public questionnaire recruited Research research and development respiratory Safety SARS-CoV-2 SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus tension Test test kits the SARS-CoV-2 virus was obtained were measured [DOI] 10.3389/fpubh.2020.599862 PMC 바로가기 [Article Type] Public Health
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates2개의 RNA 기반 Covid-19 백신 후보의 안전성 및 면역원성Clinical Trial Published on 2020-12-172022-09-12 Journal: The New England Journal of Medicine [Category] MERS, SARS, 임상, 진단, [키워드] acute respiratory syndrome added Adults age assigned BNT162b1 BNT162b2 candidate conducted convalescent serum coronavirus coronavirus disease defined disease dose dose-dependent dose-escalation doses Efficacy elicited ENCODE full-length geometric mean titer geometric mean titers Germany group healthy immunogenicity immunogenicity data incidence Infection Interim Local Multiple nucleoside-modified RNA observer-blinded of BNT162b2 Older participant Participants phase 1 trial Placebo placebo-controlled prefusion conformation Primary outcome randomization Randomly receive reported resulting Safety SARS-CoV-2 secondary outcome secreted severity spread to Support systemic reaction The United States the vaccine Trial Vaccine vaccine candidate vaccine dose [DOI] 10.1056/NEJMoa2027906 PMC 바로가기 [Article Type] Clinical Trial
Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic StrategiesReview Published on 2020-12-172024-09-02 Journal: Frontiers in Cell and Developmental Biology [Category] 대상포진, [키워드] Advanced therapy medicinal products ATMP Efficacy Market size Safety [DOI] 10.3389/fcell.2020.547653 PMC 바로가기 [Article Type] Review
Application of Lean 6s Methodology in an Engineering Education Environment during the SARS-CoV-2 PandemicArticle Published on 2020-12-152022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] 6S application auxiliary cause caused Compliance condition education Efficiency effort Engineering Environment epidemiological situation equipment Health implementation include Laboratory lean methodology occupational PDCA prevention Protective Regulation required risk Safety SARS-CoV-2 selected service standardized process the SARS-CoV-2 [DOI] 10.3390/ijerph17249407 PMC 바로가기 [Article Type] Article
Retrospective observational study of temporal trends and outcomes of hepatitis B screening in patients receiving rituximabObservational Study Published on 2020-12-152023-06-09 Journal: BMJ Open [Category] B형 간염, [키워드] adverse events gastrointestinal infections guidelines health & hepatobiliary disease Preventive medicine protocols & Safety [DOI] 10.1136/bmjopen-2020-043672 PMC 바로가기 [Article Type] Observational Study
Preliminary Results of the FASM Study, an On-Going Italian Active Pharmacovigilance ProjectArticle Published on 2020-12-152024-09-02 Journal: Pharmaceuticals [Category] 대상포진, [키워드] adverse drugs reactions Disease-modifying therapies FASM study multiple sclerosis pharmacovigilance project Safety [DOI] 10.3390/ph13120466 PMC 바로가기 [Article Type] Article
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Ascending Dose and Food Effect Study to Evaluate the Tolerance, Pharmacokinetics of Jaktinib, a New Selective Janus Kinase Inhibitor in Healthy Chinese Volunteersarticle Published on 2020-12-142024-09-02 Journal: Frontiers in Pharmacology [Category] 대상포진, [키워드] food effect jaktinib pharmacokinetics Phase I Safety [DOI] 10.3389/fphar.2020.604314 PMC 바로가기 [Article Type] article