Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virusResearch Published on 2016-03-152023-05-31 Journal: Virology Journal [Category] Fulltext, [키워드] Avian influenza virus chemokine chicken cytokine H7N9 Human IL-8 interferon Interferon lambda 1 Viral load [DOI] 10.1186/s12985-016-0498-2 PMC 바로가기 [Article Type] Research
Cytosolic Innate Immune Sensing and Signaling upon InfectionReview Published on 2016-03-142023-08-30 Journal: Frontiers in Microbiology [Category] E형 간염, [키워드] DNA Immunity interferon MAVS pathogen RNA STING [DOI] 10.3389/fmicb.2016.00313 PMC 바로가기 [Article Type] Review
Toll-IL1 receptor-mediated innate immune responses vary across HBV genotype and predict treatment response to pegylated-IFN in HBeAg-positive CHB patientsArticle Published on 2016-03-012023-06-19 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] Chronic HBV Genotype Innate immunity interferon Treatment response [DOI] 10.1111/jvh.12477
Comparison of three neurotropic viruses reveals differences in viral dissemination to the central nervous system세 가지 신경병원성 바이러스의 비교는 중앙 신경계로의 바이러스 전파에서의 차이를 드러낸다.journal-article Published on 2016-01-012024-08-01 Journal: The Orthopedic clinics of North America [Category] 폴리오, [키워드] barrier interferon neurotropic Poliovirus Reovirus Sciatic nerve virus Yellow fever virus 17D. [DOI] 10.1016/j.virol.2015.09.019 [Article Type] journal-article
An update on the strategies used for the treatment of chronic hepatitis B in childrenReview Published on 2016-01-012023-06-16 Journal: Expert review of gastroenterology & hepatology [Category] B형 간염, [키워드] antiviral therapy children entecavir HBV infection interferon [DOI] 10.1586/17474124.2016.1139450 [Article Type] Review
Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common MarmosetArticle Published on 2015-12-152023-06-15 Journal: The Journal of Infectious Diseases [Category] MERS, [키워드] animal Common marmoset coronavirus interferon Kaletra Lopinavir MERS mycophenolate primate Treatment [DOI] 10.1093/infdis/jiv392 PMC 바로가기
Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targetsArticle Published on 2015-12-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] abrogated Analysis Antiviral antiviral response antiviral responses antiviral signaling Asia binding contribute coronavirus country cytoplasm cytoplasmic determinant Europe evade highly pathogenic IFN IFN-α/β IFN-β IKKε inhibit Interaction interferon IRF3 IκB MAVS MDA5 mechanism MERS-CoV Middle East mitochondrial molecular interaction Mortality North nuclear nuclear localization signal nucleus ORF4b other coronavirus Pathogenesis pathogenicity Phosphorylation previous study Protein Regulatory respiratory syndrome coronavirus RIG-I shown significantly spread to subsequent suppress TANK target TBK1 the interferon therapeutic Type I IFN type I interferon virulence virus [DOI] 10.1038/srep17554 PMC 바로가기 [Article Type] Article
Protective efficacy of IFN-ω AND IFN-λs against influenza viruses in induced A549 cellsComparative Study Published on 2015-12-012023-06-24 Journal: Acta virologica [Category] 신종인플루엔자, [키워드] Antiviral effect Influenza virus interferon Replication [DOI] 10.4149/av_2015_04_413 [Article Type] Comparative Study
Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathwayResearch Published on 2015-08-182022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Activation adapter African green monkey antiviral immune response blockade blocked cell line damaged demonstrated digestive disorders epidemic diarrhea epithelial cell expression Host identify IFN IFN-β immune cell population immune function in vitro in vivo induce Infection inhibit inhibited inhibitor of κB innate immune system Interaction interferon Intervention intestinal epithelia intestinal epithelial cell intestinal epithelial cells investigated kidney kinase-ε lack Limited mechanism molecular mechanism NF-κB nuclear offered Pathogenesis pathway PEDV promoter Regulatory Result RIG-I signaling pathway target cell transcription factors Type type I interferon upstream Vero Cell virus were used [DOI] 10.1186/s12985-015-0345-x PMC 바로가기 [Article Type] Research
RIG-I and TLR3 are both required for maximum interferon induction by influenza virus in human lung alveolar epithelial cellsArticle Published on 2015-08-012023-06-24 Journal: Virology [Category] 신종인플루엔자, [키워드] A549 AEC Human Influenza Innate immunity interferon lung PR8 RIG-I TLR3 [DOI] 10.1016/j.virol.2015.03.048 PMC 바로가기