Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studiesResearch Article Published on 2015-04-282022-10-28 Journal: BMC Structural Biology [Category] Coronavirus, [키워드] 3CL 3CL pro 3CLpro binding compounds coronavirus coronavirus determine experimental validation generate homology homology model homology modelling Human Human coronavirus human coronavirus OC43 inhibit inhibited inhibitor inhibitors inhibitory effect Ligand molecular molecular dynamics OC43 other coronaviruses predicted protease provide receptor respiratory Result SARS-CoV shown stability Support was used [DOI] 10.1186/s12900-015-0035-3 PMC 바로가기 [Article Type] Research Article
Profiling of Substrate Specificities of 3C-Like Proteases from Group 1, 2a, 2b, and 3 CoronavirusesResearch Article Published on 2011-11-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 3CL pro acute respiratory syndrome Betacoronavirus cleaved coronavirus correlated CoV CoVs different finding Gln group human CoV hydrophobic residue hydrophobicity IBV Infection Infectious Bronchitis Virus inhibitor NL63 OC43 polyprotein Profiling protease Proteases protein sequences Proteolytic processing residue residues SARS-CoV secondary structure sequence similarity Specificities specificity structural property Substitution substrate variant viral replication Volume [DOI] 10.1371/journal.pone.0027228 PMC 바로가기 [Article Type] Research Article
Profiling of Substrate Specificity of SARS-CoV 3CL proResearch Article Published on 2010-10-062022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 3CL pro autocleavage charged residue cleavage Coronaviral correlated demonstrated detected different electrostatic interaction energy transfer finding fluorescent protein found Gln hydrophobic hydrophobic residue in vitro Infection inhibitors Mutagenesis polyprotein Profiling protease required residue residues SARS-CoV sequence solvent specificity Structural properties substitutions substrate variant wild-type β-sheet [DOI] 10.1371/journal.pone.0013197 PMC 바로가기 [Article Type] Research Article
Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombinationShort Report Published on 2008-12-222022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] 3CL pro Analysis analyzed circulating Comparative compared coronavirus Coronaviruses different DPI Evolution found Genes Genome genomic RNA genomic sequence Gray IBV identity Infectious Bronchitis Virus intergenic region nucleotides occur occurred open reading frames other coronavirus Point mutation polymerase Possible proteinase RdRP Recombination recombination event sequence Sequence analysis sequenced similarity spike gene strain Strains UTR virulent [DOI] 10.1186/1743-422X-5-157 PMC 바로가기 [Article Type] Short Report