Immune Escape Associated with RBD Omicron Mutations and SARS-CoV-2 Evolution DynamicsRBD 오미크론 돌연변이 및 SARS-CoV-2 진화 역학과 관련된 면역 탈출Review Published on 2022-07-222022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] absence Affect appearance bioinformatics COVID-19 COVID-19 pandemic described Dynamics escape Evolution explained Features Genome high affinity high mutation rate Host immune Immune escape Lineage Mutation mutation rate natural immunity omicron pathogenicity Protein RBD RBD mutations receptor SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 strains serotype Spike protein the Spike therapeutic therapeutic agent therapeutic agents Transmissibility Vaccine Vaccine development variant virus [DOI] 10.3390/v14081603 PMC 바로가기 [Article Type] Review
A comparison of high-throughput SARS-CoV-2 sequencing methods from nasopharyngeal samples비인두 샘플의 고처리량 SARS-CoV-2 시퀀싱 방법 비교Article Published on 2022-07-222022-09-11 Journal: Scientific Reports [Category] Coronavirus, COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] absence acute respiratory syndrome coronavirus amplification applied approach caused coronavirus 2 Coverage COVID-19 pandemic COVIDSeq detect epidemiological genomic Genomic surveillance Healthcare system Healthcare systems infected individuals limitation multiplex nasopharyngeal sample Nasopharyngeal samples Nasopharyngeal swab nasopharyngeal swabs Next-generation sequencing pandemic of COVID-19 public health respiratory risk SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequencing SARS-CoV-2 sequencing severe acute respiratory syndrome coronavirus 2 successive wave supply shortage Supply shortages Surveillance tested Transmissibility Treatment Vaccine variant variants virulence was obtained whole genome [DOI] 10.1038/s41598-022-16549-w PMC 바로가기 [Article Type] Article
Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infectionSARS-CoV-2 감염 진단을 위한 신속한 현장 진료 항원 검사Review Published on 2022-07-222022-09-11 Journal: The Cochrane database of systematic reviews [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] 95% CI 95% confidence interval absence access Accuracy age Antigen antigen test antigen tests approach assays Asymptomatic average Bern bioRxiv brand can not carried Chain Reaction Characteristics checked CIs Cohort Compliance conducted COVID-19 COVID-19 pandemic COVID-19 testing criteria criterion Data collection database demonstrated described detect diagnosis of SARS-CoV-2 diagnostic Diagnostic accuracy diagnostic tests Effectiveness eligible epidemiological estimate Europe evaluate evaluated Evidence exposure to False positive False positives global health groups Health Organization healthcare help heterogeneity highest include independent indication Infection Interpretation investigated logistic regression models management Mass screening measure medRxiv molecular test National Open Access Other participant Participants Patient care point-of-care polymerase chain polymerase chain reaction population groups Positive predictive value positive result PPV Predictive value presence or absence Prevalence produced public health QUADAS-2 random-effect ranged Rapid rapid antigen test Rapid antigen tests Rapid diagnostic test reduce reducing reference reference standard Reference standards repeated reported Research respiratory respiratory sample resulting reverse transcription reverse transcription polymerase chain reaction RT-PCR RT-PCR testing SARS-CoV-2 SARS-COV-2 infection Schools screened screening procedure screening programmes searched second Selection sensitivities sensitivity Sensitivity and specificity Seven Signs and symptoms Source Specificities specificity study cohort Study design Symptom symptom onset symptom status symptomatic symptomatic and asymptomatic symptomatic participant symptomatic participants symptomatic people symptoms of COVID-19 test negative test result Testing to define Transmission Triage unique University of Bern variable Viral Viral load viral loads website were used WHO World Health Organization [DOI] 10.1002/14651858.CD013705.pub3 PMC 바로가기 [Article Type] Review
Kinetics of anti-nucleocapsid IgG response in COVID-19 immunocompetent convalescent patientsCOVID-19 면역적격 회복기 환자에서 항뉴클레오캡시드 IgG 반응의 동역학Article Published on 2022-07-202022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] absence anti-Nucleocapsid IgG anti-SARS-CoV-2 anti-SARS-CoV-2 humoral antibody Antibody Response Antibody testing BMI comprehension convalescent patient Convalescent patients country COVID-19 COVID-19 convalescent patient COVID-19 disease decrease detectable develop disease severity humoral humoral immune response IgG IgG antibodies IgG antibody immunodeficiency inclusion criteria Kinetics knowledge longitudinal study majority Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples nucleocapsid Patient positive Protein Re-infection robust RT- PCR SARS-CoV-2 SARS-CoV-2 nucleocapsid serum Sex Treatment Vaccination strategies Vaccination strategy virus infection [DOI] 10.1038/s41598-022-16402-0 PMC 바로가기 [Article Type] Article
Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into CellsSARS-CoV-2 세포로의 진입을 완전히 차단하려면 Vacuolar-ATPase 및 TMPRSS2의 이중 억제가 필요합니다Article Published on 2022-07-192022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] absence Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ATPase bafilomycin block viral entry camostat cathepsin inhibitor Cathepsins Cell cellular Compound coronavirus E64d Efficacy endosomal pH endosomal protease endosome expressing highlight host cell host protease host proteases Hydroxychloroquine identify implicated Infection inhibit inhibiting inhibition inhibitor inhibitors Intervention life cycle Macrolide maturation mechanisms membrane fusion molecules Neutralizing nonspecific Pathways pharmacological agent Prevent protease Protein proteolytic activation provide pseudotyped rationale S protein SARS SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Serine serine 2 serine proteases severe acute respiratory syndrome Coronavirus synergy the S protein these compound these compounds TMPRSS2 TMPRSS2 inhibitor TMPRSS2-expressing cells toxicities Toxicity transmembrane V-ATPase viral entry viral spike virus [DOI] 10.1128/aac.00439-22 PMC 바로가기 [Article Type] Article
A qualitative process analysis of daily contact testing as an alternative to self-isolation following close contact with a confirmed carrier of SARS-CoV-2SARS-CoV-2의 확인된 보균자와의 긴밀한 접촉 후 자가 격리의 대안으로 일일 접촉 테스트의 정성적 프로세스 분석Randomized Controlled Trial Published on 2022-07-182022-09-11 Journal: BMC Public Health [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] absence alternative Analysis Attitude behavioural benefit chain Chain Reaction close contact conducted Contact contact with COVID-19 Daily DCT detect Factor feasible Flow Infection Interpretation interview Isolation Lateral Lateral flow device Lateral flow test participant PCR polymerase chain reaction Process process evaluation provided Qualitative randomised randomised controlled trial reaction reassurance reduce reducing reported risk risk of transmission SARS-CoV-2 SARS-CoV-2 transmission Self-isolation Seven study period Test Testing Trial were used [DOI] 10.1186/s12889-022-13800-x PMC 바로가기 [Article Type] Randomized Controlled Trial
Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273SARS-CoV-2의 면역 역학은 면역 억제된 류마티스 관절염 또는 mRNA-1273 예방 접종을 받은 다발성 경화증 환자를 경험했습니다.Article Published on 2022-07-152022-09-12 Journal: eLife [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence acute respiratory syndrome affected analyzed anti-CD20 antibody Autoimmune Autoimmune disease Autoimmune diseases B cell response benefit CD4 CD8 Cell cellular cellular immunity central memory circulating condition coronavirus COVID-19 COVID-19 mRNA vaccine development disease Disease activity European European Commission first vaccination flow cytometry follicular HCs healthy control Horizon Human humanized humoral Humoral immunity IgG immune immune response Immunity immunology Immunosuppressant immunosuppressants Immunosuppressed increased risk Infection Inflammation leadership longitudinal marker Medicine methotrexate Moderna monoclonal antibody monotherapy mRNA mRNA-1273 MTX multiple sclerosis Netherland organization outcome Patient patients treated preserved recall Research resulting rheumatoid arthritis SARS-CoV-2 second vaccination shielding significantly supported suppress sustained T cell T cell response T cells T helper the SARS-CoV-2 treated Treatment union vaccination Vaccine vulnerable patients whole blood sample [DOI] 10.7554/eLife.77969 PMC 바로가기 [Article Type] Article
A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection단일 T 세포 에피토프를 사용한 세 번째 백신 접종은 SARS-CoV-2 감염의 쥐 모델에서 보호를 제공합니다Article Published on 2022-07-082022-09-12 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] absence approach booster vaccination CD8 characterized cytokine production develop dose dose regimen elicit epitope epitope peptide fraction IMPROVE K18-hACE2 mechanism memory T cells murine model Neutralizing antibodies peptide repeated SARS-CoV-2 SARS-COV-2 infection spike T cell T cell response Transgenic mouse understanding vaccination Vaccine vaccine dose [DOI] 10.1038/s41467-022-31721-6 PMC 바로가기 [Article Type] Article
Vaccination and variants: Retrospective model for the evolution of Covid-19 in Italy예방 접종 및 변종: 이탈리아의 Covid-19 진화에 대한 회고 모델Article Published on 2022-07-082022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] absence appearance changes characterized combined effect compartmental model contagious COVID-19 pandemic deaths decreases delta variant develop dominant effective Effects epidemiological Evolution followed by individual induce Infection Italy measure mechanism mechanisms normality omicron Omicron variant pandemic Particular predict Retrospective analysis seasonal variation stability vaccination Vaccine Variability variant Variation virus virus infectivity waning immunity [DOI] 10.1371/journal.pone.0265159 PMC 바로가기 [Article Type] Article
Understanding Immune Responses to Viruses-Do Underlying Th1/Th2 Cell Biases Predict Outcome?바이러스에 대한 면역 반응 이해 - 기본 Th1/Th2 세포 편견이 결과를 예측합니까?Review Published on 2022-07-082022-09-11 Journal: Viruses [Category] 치료기술, [키워드] absence adaptive age belief Biase Biomarkers Chikungunya contributed COVID-19 pandemic Ebola Epidemics Ethnicity Factor helper cell Host immune responses immune system Immunity immunity pathway include Infection inherent inherent biase outcome overcome Pathologies pathology Patient predict reactive response risk T helper cell T-cells understanding viral disease Viral diseases viral infection virotherapy virus viruses Zika Zika viruses [DOI] 10.3390/v14071493 PMC 바로가기 [Article Type] Review