Mortality in Patients with COVID-19 on Renin Angiotensin System Inhibitor Long-Term Treatment: An Observational Study Showing that Things Are Not Always as They SeemObservational Study Published on 2021-05-012022-10-05 Journal: Advances in therapy [Category] SARS, 임상, [키워드] ACE ACE inhibitor ACE inhibitors Admission age angiotensin Angiotensin receptor blockers Angiotensin-converting enzyme ARB ARBs blocker concerning condition conducted consecutive patient coronavirus disease COVID-19 death defined determinant diabete died disease drug First wave had no high mortality rate hospital hypertension increased mortality increased risk inhibitor Italy Laboratory long-term treatment Mild moderate Mortality Multivariate analysis multivariate model no significant difference pandemic patients with COVID-19 physician receiving receptor Renin reported System the patient treated was used with COVID-19 [DOI] 10.1007/s12325-021-01704-y PMC 바로가기 [Article Type] Observational Study
Angiotensin-converting enzyme-1 gene insertion/deletion polymorphism may be associated with COVID-19 clinical severity: a prospective cohort study안지오텐신 전환 효소-1 유전자 삽입/제거 다형성이 COVID-19 임상 중증도와 관련될 수 있음: 전향적 코호트 연구Article Published on 2021-05-012022-09-11 Journal: Annals of Saudi medicine [Category] 바이오마커, 변종, [키워드] 95 % CI 95% CI ACE advanced age agarose gel electrophoresis age angiotensin Asymptomatic Asymptomatic disease asymptomatic patients Care Chain Reaction Clinical data Clinical severity cohort study collected Comorbidity conflict conflict of interest COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients determined by diabetes Diabetes Mellitus died disease disease severity dominant enzyme frequencies Frequency Genotype heart disease hospital I/D I/D genotype I/D polymorphism independent risk factor independent risk factors insertion/deletion ischemic heart disease Mild nine outcome Pathogenesis Patient polymerase chain polymerase chain reaction polymorphism Prospective prospective cohort study Protective Sample Sample size severe COVID-19 severe disease significantly single center small sample size Tertiary whole blood sample with COVID-19 [DOI] 10.5144/0256-4947.2021.141 PMC 바로가기 [Article Type] Article
Dysregulation of the Renin-Angiotensin-Aldosterone System (RAA) in Patients Infected with SARS-CoV-2-Possible Clinical ConsequencesReview Published on 2021-04-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE ACE inhibitor ACE2 angiotensin Angiotensin-converting enzyme Arterial hypertension balance binding biological activity blood pressure Cell changes in clinical Concentration consequence Critical decrease Disturbed domination dose enzyme host cells Human impair Inflammation inhibited Lungs metabolism precursor produced Protective receptor reduced reducing regulate renin-angiotensin-aldosterone system SARS-CoV-2 System Treatment [DOI] 10.3390/ijms22094503 PMC 바로가기 [Article Type] Review
Arthropod Ectoparasites Have Potential to Bind SARS-CoV-2 via ACEArticle Published on 2021-04-192022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] ACE ACE2 Analysis Arthropod bind binding energy build complex COVID-19 Ectoparasite experimental evidence good quality hosts human Ace2 protein Impact in silico Infection Interaction Mutation organism parasite performed Potential predicted Protein Proteins question raising risk SARS-CoV-2 sequence similarity spike Spike protein stability structural bioinformatics the SARS-CoV-2 Transmission vector virus [DOI] 10.3390/v13040708 PMC 바로가기 [Article Type] Article
The effects of ACE2 expression mediating pharmacotherapy in COVID-19 patientsGuideline Published on 2021-04-162022-10-30 Journal: Netherlands Heart Journal [Category] COVID-19, [키워드] ACE ACE2 ACE2 expression ACEi ACEIs acute kidney failure Acute kidney injury acute lung injury angiotensin receptor blocker ARB ARBs COVID-19 COVID-19 infected patients database demonstrated described drug Effect Evidence expression fibrosis groups Hospital admission Hospital stay hypertensive patient ICU admission increased mortality Infection Inflammation inhibitor mechanical ventilation medication methodology Mortality nine nonsteroidal anti-inflammatory drug NSAIDS outcome outcome measure pulmonary permeability question RAAS reduce renal replacement therapy Result searched severity of COVID-19 stroke suggested supplementary material susceptibility systematic analysis thromboembolic complication thromboembolic complications two groups was performed [DOI] 10.1007/s12471-021-01573-8 PMC 바로가기 [Article Type] Guideline
Feasibility of an Outpatient Training Program after COVID-19Brief Report Published on 2021-04-092022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] ACE aerobic benefit consequence coronavirus disease COVID-19 COVID-19/SARS-CoV-2 discharged home dose enrolled feasibility feasible hospital discharge Hospitalization intensity Intervention investigated outcome Outpatient outpatient pulmonary rehabilitation Patient physical physical activity Physiotherapy preliminary finding Program protocol provided pulmonary rehabilitation recovering from COVID-19 recruited recruitment reported Resistance training study period subgroup of patient Support Tolerability training [DOI] 10.3390/ijerph18083978 PMC 바로가기 [Article Type] Brief Report
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivationSARS-CoV-2는 JAK1/2 종속 국소 보체 과활성화를 유도합니다.Research Articles Published on 2021-04-072022-09-12 Journal: Science Immunology [Category] MERS, SARS, 진단, [키워드] ACE activated Activation affecting Alternative pathway angiotensin angiotensin converting enzyme Antiviral blocked Bronchoalveolar lavage C3 convertase C3a Cell cell lines clinical manifestation Combination combination therapy complement Complement activation Complement C3 complement component complement system convertase coronavirus disease Coronavirus disease 2019 COVID-19 disease severity disease-causing driver drug entry receptor epithelial cell epithelial cells expressed expression Genes Gut Hyperactivation implicated induce infected cells inhibited inhibitor interferon JAK inhibitor jak inhibitors JAK1 kidney kidneys liver Local lung epithelial Lung epithelial cells Lungs lymphoid normalized not affect pathway Pathways patients processing produced Protein Remdesivir respiratory epithelial cell respiratory epithelial cells ruxolitinib SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Signaling Stat1 the disease tissues transcript Transcription underlie virus [DOI] 10.1126/sciimmunol.abg0833 PMC 바로가기 [Article Type] Research Articles
Maternal endothelial dysfunction in HIV-associated preeclampsia comorbid with COVID-19: a reviewReview Published on 2021-04-012022-10-04 Journal: Hypertension research : official journal of the Ja [Category] 비임상, 신약개발, 치료제, [키워드] ACE acute respiratory syndrome Angiogenesis angiotensin-converting enzyme 2 Antiretroviral therapy Antiretrovirals antiviral drug ART caused coronavirus Coronavirus disease 2019 COVID-19 COVID-19 therapeutics drug Effect Effectiveness elevated endothelial Endothelial dysfunction endothelial injury evaluate Evidence growth factor HIV HIV infection homology Human immunodeficiency virus hypertension immune states impair Inclusion induce Infection Interaction lack marker Maternal mimicking Mortality neutralization platform preeclampsia pregnancies Pregnancy pregnant women Protective Protein provide RDV Remdesivir Research risk factor SARS-CoV-2 SARS-COV-2 infection Severe case subsequent syndrome Transcription Trial understanding Vascular women [DOI] 10.1038/s41440-020-00604-y PMC 바로가기 [Article Type] Review
The assessment of serum ACE activity in COVID-19 and its association with clinical features and severity of the diseaseCOVID-19의 혈청 ACE 활성 평가 및 질병의 임상적 특징 및 중증도와의 연관성 평가Article Published on 2021-04-012022-09-11 Journal: Scandinavian journal of clinical and laboratory in [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] ACE ACE activity acute lung injury acute respiratory distress acute respiratory distress syndrome Admission angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme (ACE) ARDS association Asymptomatic autoanalyzer baseline characteristics clinical feature Clinical features comparable Control control group correlation COVID-19 demographic demographic data disease disease severity Effect enrolled enzyme evaluated female groups healthy subject Hemostasis immune responses Inflammation inflammatory markers Laboratory Lung injury marker marker. median median age Mild no correlation nucleic acid on admission pathway Patient patients with COVID-19 radiologic Regulatory respiratory distress Respiratory distress syndrome RT-PCR SARS-COV-2 infection SARS-CoV-2 nucleic acid serum severe pneumonia severity syndrome the disease were recorded [DOI] 10.1080/00365513.2021.1871641 PMC 바로가기 [Article Type] Article
RAMIC: Design of a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of ramipril in patients with COVID-19RAMIC: COVID-19 환자에서 라미프릴의 효능을 평가하기 위한 무작위, 이중 맹검, 위약 대조 시험 설계Article Published on 2021-04-012022-09-11 Journal: Contemporary clinical trials [Category] MERS, SARS, 바이오마커, 임상, [키워드] ACE Adult patients angiotensin Complication composite endpoint coronavirus disease Coronavirus disease 2019 COVID-19 death decrease diastolic double-blind Efficacy emergency department Endpoint evaluate exclusion criteria filtration rate glomerular filtration rate hospital ICU admission include Informed consent inhibitor Invasive mechanical ventilation Mechanical mechanical ventilation mechanical ventilator mitigate Mortality multicenter Novel coronavirus novel coronavirus disease occur patients with COVID-19 Personal protective equipment Placebo placebo-controlled trial PPE primary composite endpoint ramipril Randomized receive reduced risk risk risk of infection risk of transmission SARS-CoV-2 transmission SARS-CoV2 shown study population study visit Systolic blood pressure Treatment Virtual visit. [DOI] 10.1016/j.cct.2021.106330 PMC 바로가기 [Article Type] Article