An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimerSARS-CoV-2의 N-말단 도메인을 표적으로 하는 항체는 스파이크 삼량체를 파괴합니다Article Published on 2022-06-012022-09-12 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Adaptive immunity antibody Antigen B cell binding Cell cell-to-cell spread Cluster coronavirus COVID-19 Culture disrupt dominant epitope functional Genetic human Angiotensin-converting enzyme human antibody response IGHV1-24 immunoglobulins immunology inhibited mice MOST N-terminal domain neutralizing antibody NTD Protective Protective antibody Protein provide receptor recognize representing S protein SARS-CoV-2 SARS-CoV-2-neutralizing antibody Sequencing single B cell specificity spike trimer the receptor-binding domain the S protein the SARS-CoV-2 trimer Trimers virion Virology virus [DOI] 10.1172/JCI159062 PMC 바로가기 [Article Type] Article
COVID-19 age-dependent immunology and clinical outcomes: implications for vaccinesReview Published on 2022-06-012023-07-06 Journal: Journal of Developmental Origins of Health and Disease [Category] COVID19(2023년), [키워드] Adaptive immunity coronavirus Cytokine storm syndrome Innate immunity Multisystem inflammatory syndrome [DOI] 10.1017/S2040174421000398 [Article Type] Review
Vaccination with BNT162b2 and ChAdOx1 nCoV-19 Induces Cross-Reactive Anti-RBD IgG against SARS-CoV-2 Variants including OmicronBNT162b2 및 ChAdOx1 nCoV-19 백신 접종은 Omicron을 포함한 SARS-CoV-2 변이체에 대한 교차 반응성 항-RBD IgG를 유도합니다Article Published on 2022-05-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] adaptive Adaptive immunity age Alpha Alpha variant anti-RBD BNT162b2 booster vaccinations Breakthrough infection breakthrough infections caused ChAdOx1 ChAdOx1 nCoV-19 Cohort contribute Course COVID-19 cross-reactive cross-reactive antibodies cross-reactivity Delta delta variant domain ELISA explain Gamma health-care IgG IgG ELISA IgG level IgG levels Immunity independent independent of individual Infection infection rate lethality magnitude morbidity nucleocapsid nucleocapsid IgG omicron Omicron variants RBD RBD IgG reactivity Receptor-binding domain Receptor-binding domain (RBD) recipient SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 variants sera Sex significant increase significantly higher significantly lower Spike protein Spread tested the spike protein university vaccination vaccination rate Vaccine variants variants of concern Vienna VoC VOCs was increased while [DOI] 10.3390/v14061181 PMC 바로가기 [Article Type] Article
T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severityT 세포 수용체 시퀀싱은 이전 SARS-CoV-2 감염을 식별하고 중화 항체 및 질병 중증도와 상관관계가 있습니다Article Published on 2022-05-232022-09-12 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adaptive Biotechnologies Adaptive immunity antibody blood sample breadth conducted correlated COVID-19 Decline diagnostics difficulty breathing disease severity evaluated Fever Frederick greater Hospitalization humoral identify immune response Improved individual induce Infection Infectious disease initial less magnitude NAb neutralizing antibody NIAID protective immunity response SARS-CoV-2 SARS-COV-2 infection sensitivity Sequencing serology serology test severe disease significantly Society Support T cell T cell receptor T cell response T cell responses TCR transplantation Trial undetectable [DOI] 10.1172/jci.insight.150070 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific immune responses in boosted vaccine recipients with breakthrough infections during the Omicron variant surge오미크론 변이체 급증 동안 돌발 감염이 있는 부스트 백신 수혜자의 SARS-CoV-2 특이적 면역 반응Article Published on 2022-05-232022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 binding Adaptive immunity allergy analyzed antibody binding booster Breakthrough infection breakthrough infections cellular response Cellular responses COVID-19 ELISpot assay funds healthy Humoral immunity immune response immune responses Infection Infectious disease inhibited Johns Hopkin Johns Hopkins less levels of antibodies levels of antibody median mRNA vaccine National Cancer Institute occur omicron Omicron variant Protein Protein binding receiving recipient recipients robust SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2-specific immune response significantly Spike protein Spike proteins supported T cell T cell response T cells the vaccine vaccinated individual vaccinated individuals Vaccine vaccine strain variant variant spike [DOI] 10.1172/jci.insight.159474 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severityArticle Published on 2022-05-192022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료법, 치료제, [키워드] Adaptive immunity Affect Blood cellular COVID-19 COVID-19 patients cytokine response Dexamethasone disease severity domain Hospital stay hospitalized COVID-19 patients humoral Humoral response IFN-α2 IgA IgG IgM IgM and IgG IL-12p70 immune immune component immune parameter immune response immunopathology infection with SARS-CoV-2 Inflammation mechanism neutralization Neutrophils not affect Peripheral blood plasma Prognosis respiratory respiratory sample Respiratory samples respiratory specimen respiratory specimens respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralization activity Seroconversion sputum subset therapy Treatment viral infection [DOI] 10.1038/s41467-022-30088-y PMC 바로가기 [Article Type] Article
[Immune response against the severe acute respiratory syndrome coronavirus 2]Article Published on 2022-05-152023-07-09 Journal: Orvosi hetilap [Category] COVID19(2023년), [키워드] adaptív immunitás Adaptive immunity antibodies B and T cell memory B- és T-sejt-memória citokinek Cytokines ellenanyagok Innate immunity interferon természetes immunitás. [DOI] 10.1556/650.2022.32521
Adaptive Immune Responses and Immunity to SARS-CoV-2SARS-CoV-2에 대한 적응 면역 반응 및 면역Review Published on 2022-05-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] activated Activation adaptive Adaptive immune response adaptive immune responses Adaptive immunity Antigen antigen-presenting cell antigen-presenting cells B cell B cell receptors B.1.1.529 B.1.617.2 backbone biological interaction Blood Blood donors Breakthrough infection breakthrough infections cellular Cellular immune response cellular immunity cellular response Clonality competence COVID-19 COVID-19 pandemic defend Defense defense mechanism Delta demonstrated heparinized blood Host humoral Humoral response humoral responses IgA immune immune reaction immune responses Immunity Immunocompromised Immunocompromised patient Immunocompromised patients Immunological memory immunology induce Infection interferon gamma interferon gamma. Interferon-gamma knowledge long-lasting maturation mechanism memory mucosal nasal omicron pandemic peptides Research response SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 T cell memory shown stimulated T cell T cell memory T cells the SARS-CoV-2 translate undetectable Vaccine Vaccines variants variants of concern Viral antigen viral particle virus [DOI] 10.3389/fimmu.2022.848582 PMC 바로가기 [Article Type] Review
A comprehensive assessment of long-term SARS-CoV-2-specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients회복기 COVID-19 고형장기 이식 수혜자의 장기 SARS-CoV-2 특이 적응 면역 기억에 대한 종합적인 평가Article Published on 2022-05-012022-09-11 Journal: Kidney international [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] adaptive Adaptive immunity Asymptomatic Clinical severity controls convalescent convalescent patient Convalescent patients COVID-19 COVID-19 infection COVID-19 severity cytokine detectable determined by driven by eight ELISA IFN-γ IFN-γ producing T cells IL-2 IL12 immune immune memory individual individuals Infection kidney liver long-lasting lung memory B cell memory B cells memory response Mild organ transplantation Patient performed producing recipient reported response SARS-CoV-2 SARS-COV-2 infection serological seropositive severity significantly Solid solid organ solid organ transplant solid organ transplantation solid organ transplants T cells Transplant transplantation while [DOI] 10.1016/j.kint.2021.12.029 PMC 바로가기 [Article Type] Article
Innate and Adaptive Immune Responses in the Upper Respiratory Tract and the Infectivity of SARS-CoV-2Review Published on 2022-04-292023-07-01 Journal: Viruses [Category] COVID19(2023년), SARS, [키워드] Adaptive immunity age and SARS-CoV-2 infectivity COVID-19 vaccines human genetics and SARS-CoV-2 infectivity Innate immunity intranasal immunization nasal epithelium upper respiratory tract immunity [DOI] 10.3390/v14050933 PMC 바로가기 [Article Type] Review