Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection
Research Article
[키워드] abrogated
absence
accumulated
acute lung injury
acute respiratory syndrome
alveolar macrophage
anti-spike antibody
Antibody Response
blockade
cause
Characteristics
Chinese
coronavirus
CoV
Cytokines
Deceased
demonstrated
died
driving
Effects
faster
FcγR
functional
H7N9
hypercytokinemia
IgG
IL-8
immunoglobulins
Infectious disease
Inflammation
Lung injury
Lungs
macaque
macaques
Macrophage response
macrophages
MCP1
mechanism
MERS-CoV
middle
neutralizing antibody responses
Patient
patients
proinflammatory
promoted
Pulmonology
recruitment
reduced
response
responsible
SARS patient
SARS-CoV
SARS-CoV infection
sera
specimens
syndrome
Treatment
viral clearance
viruses
[DOI] 10.1172/jci.insight.123158 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1172/jci.insight.123158 PMC 바로가기 [Article Type] Research Article