Antiviral effect – Page 11 – Communicable Diseases Research

Lactoferrin as Antiviral Treatment in COVID-19 Management: Preliminary Evidence

COVID-19 관리에서 항바이러스제로서의 락토페린: 예비 증거

Article

Published on 2021-10-192022-09-10
Journal: International Journal of Environmental Research an [Category] MERS, SARS, 치료제,

The therapeutic promises of Lianhuaqingke in the mice model of coronavirus pneumonia (HCoV-229E and SARS-CoV-2)

Research

Published on 2021-10-182022-11-01
Journal: Chinese Medicine [Category] COVID-19,

[키워드] 16HBE cell acute pneumonia airway alleviate Anti-HCoVs therapy Anti-viral Antiviral effect approved BALB/c mice caused Cell cells ciliary Coronavirus pneumonia COVID-19 dose-dependent Effect ELISA epithelial expression expression level flow cytometry H&E staining hACE2 HCoV-229E human coronaviruses (HCoVs) identify immune response immunofluorescence staining immunomodulation immunomodulatory in vitro in vivo indicated inhibit inhibited inhibiting Injury Lianhuaqingke (LHQK) lung lung tissue lung tissues mice morphological change MUC5AC Peripheral blood Pneumonia positive pro-inflammatory cytokine reduce reduced reducing Replication Result SARS-CoV-2 staining subset Th cell Th1 Th17 Th2 the SARS-CoV-2 virus therapeutic therapeutic effect Therapies TNFα Transgenic mouse treated Treatment Treg Vero E6 viral replication virus virus titer was measured was used weight loss were measured
[DOI] 10.1186/s13020-021-00513-3 PMC 바로가기 [Article Type] Research

Beneficial effects of a mouthwash containing an antiviral phthalocyanine derivative on the length of hospital stay for COVID-19: randomised trial

Covid-19의 입원 기간에 대한 항 바이러스 프탈로시아닌 유도체를 함유하는 구강 세척의 유익한 효과 : 무작위 시험

Randomized Controlled Trial

Published on 2021-10-072022-08-13
Journal: Scientific Reports [Category] MERS, SARS, 임상, 치료기술, 치료제,

[키워드] adjuvant Admission age anionic phthalocyanine derivative Antiviral antiviral activity Antiviral effect antiviral effects APD association both groups Care clinical clinical condition clinical study clinical trial Comorbidities Compound conducted Contamination control group COVID-19 cytotoxicity death demonstrated dissemination duration of symptom Effect effective evaluated experimental group group Health Organization hospital hospital discharge Hospital stay hospitalized patient ICU ICU care in both group in vitro indicated infected with SARS-CoV-2 Infection intensive care unit Intervention LOS Mouthwash mouthwash protocol nasal nonactive mouthwash number of comorbidities Patient pharyngeal photoexcitation phthalocyanine positive presence of comorbidities protocol Randomised trial Randomized controlled trial reduce reduced reducing reduction Registered Research risk SARS-CoV-2 SARS-CoV-2 viral load severity of symptom Sex significantly Spread standard care Symptom tested the median the patient Treatment Trial registration triple-blind triple-blind randomized controlled trial Two-arm Viral World Health Organization
[DOI] 10.1038/s41598-021-99013-5 PMC 바로가기 [Article Type] Randomized Controlled Trial

Plausible Positive Effects of Statins in COVID-19 Patient

COVID-19 환자에서 스타틴의 그럴듯한 긍정적 효과

Review

Published on 2021-10-012022-09-11
Journal: Cardiovascular toxicology [Category] SARS, 치료제,

Efficacy and safety of hydroxychloroquine as pre-and post-exposure prophylaxis and treatment of COVID-19: A systematic review and meta-analysis of blinded, placebo-controlled, randomized clinical trials.

Research article

Published on 2021-10-012022-10-05
Journal: The Lancet Regional Health - Americas [Category] 신약개발, 임상, 치료법, 치료제,

[키워드] 95% CI 95% confidence interval adverse event Anti-inflammatory antiviral activity Antiviral effect blinded clinical benefit clinical study close contact Cochrane guideline continuous variable COVID-19 death demonstrated dichotomous variable Effect Efficacy and safety element eligibility evaluate Evidence finding FIVE fixed funding funding source Gastrointestinal symptom HCQ heterogeneity Hospital stay Hospitalization hospitalized patient Hydroxychloroquine immunomodulatory in vitro incidence increased risk individual Invasive mechanical ventilation lack mean difference medication Meta-analysis moderate outcome Outpatient patients patients with COVID-19 performed Placebo placebo-controlled positive Prevent Prophylactic Prophylaxis random-effects model randomized clinical trial randomized clinical trials RCT RCTs receiving reported risk SARS-CoV-2 SARS-COV-2 infection systematic review to define Treatment Trial was used Web of Science website were used with COVID-19
[DOI] 10.1016/j.lana.2021.100062 [Article Type] Research article

Potential Therapeutic Applications of Pulmonary Surfactant Lipids in the Host Defence Against Respiratory Viral Infections

호흡기 바이러스 감염에 대한 숙주 방어에서 폐 계면활성제 지질의 잠재적 치료 응용

Review

Published on 2021-09-272022-09-11
Journal: Frontiers in Immunology [Category] SARS, 치료제,

The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

몰누피라비르와 파비피라비르의 병용 치료는 SARS-CoV-2 햄스터 감염 모델에서 항바이러스 효능을 강화합니다

Research paper

Published on 2021-09-242022-09-11
Journal: EBioMedicine [Category] MERS, 치료기술, 치료제,

Lectin from Triticum vulgaris (WGA) Inhibits Infection with SARS-CoV-2 and Its Variants of Concern Alpha and Beta

Triticum vulgaris(WGA)의 렉틴은 SARS-CoV-2 및 그 변종 우려 알파 및 베타의 감염을 억제합니다

Article

Published on 2021-09-222022-09-10
Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 치료제,

[키워드] added administration Agglutinin Alpha Antiviral antiviral activity Antiviral effect Beta binding Calu-3 comparable Compound concern COVID-19 effective exhibit free virion free virions Germ human coronavirus human coronavirus OC43 Hypothesis Infection inhibit lectin lectin from Triticum vulgaris lung cell mode natural compounds Neutralizing preincubation Prophylaxis respiratory Respiratory tract infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections therapeutic therapeutic windows Treatment Triticum vaccination variants variants of concern Vero B4 cells Viral viral entry virus viruses WGA wheat Wheat Germ Agglutinin wild type
[DOI] 10.3390/ijms221910205 PMC 바로가기 [Article Type] Article

In Silico Evaluation of Iranian Medicinal Plant Phytoconstituents as Inhibitors against Main Protease and the Receptor-Binding Domain of SARS-CoV-2

SARS-CoV-2의 주요 프로테아제 및 수용체 결합 도메인에 대한 억제제로서의 이란 약용 식물 식물 성분의 실리코 평가

Article

Published on 2021-09-212022-09-10
Journal: Molecules [Category] SARS, 유전자 메커니즘, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral effect astragalin binding free energy caused chelidimerine comorbid condition comorbid conditions complexes component components coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infection COVID-19 cultures determine disease domain drug Effectiveness elderly focus free energy gallate global pandemic Human illness illnesses individual Infection inhibitor inhibitors Interaction Laboratory M pro main protease mechanism medicinal plant Medicines molecular docking molecular dynamics Molecular dynamics simulation natural Novel coronavirus novel coronavirus disease plant plants Prevent protease Proteins RBD Receptor-binding domain Research respiratory rutin SARS-CoV-2 severe acute respiratory syndrome Coronavirus specific treatment structure-based design treat variety Wuhan Wuhan, China
[DOI] 10.3390/molecules26185724 PMC 바로가기 [Article Type] Article

Computationally repurposed drugs and natural products against RNA dependent RNA polymerase as potential COVID-19 therapies

Research

Published on 2021-09-202022-10-30
Journal: Molecular Biomedicine [Category] COVID-19,