balance – Page 11 – Communicable Diseases Research

Biofilm microenvironment induces a widespread adaptive amino-acid fermentation pathway conferring strong fitness advantage in Escherichia coli

생물막 미세 환경은 대장균에 강력한 적합성을 부여하는 광범위한 적응 아미노산 발효 경로를 유도합니다

Research Article

Published on 2017-05-192022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

NF-YB Regulates Spermatogonial Stem Cell Self-Renewal and Proliferation in the Planarian Schmidtea mediterranea

NF-YB는 Planarian Schmidtea 지중해에서 정자 줄기 세포 자가 재생 및 증식을 조절합니다

Research Article

Published on 2016-06-152022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] balance carrier causative agent Cell cell population cell proliferation cells combating complex component conserved coordination developmental differentiation disease Disruption etiology Factor fecundity Gamete genetic information germ cell germ cells help homolog identification implication Implications infertility inhibited involved lead life maintenance male mechanism morbidity observation open organism Organisms parasite Pathogenesis Planarian proliferation Propagation reproductive required Schistosoma mansoni schistosome Schistosomiasis Sperm SSC STEM stem cell stem cells testes transcription factors Transmission tropical tropical disease Tumor tumorigenesis tumors
[DOI] 10.1371/journal.pgen.1006109 PMC 바로가기 [Article Type] Research Article

Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response

대식세포에서 엔도글린이 결핍된 마우스는 손상된 면역 반응을 보여줍니다

Research Article

Published on 2016-03-242022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] absence ACVRL1 analyzed animals Antigen autosomal dominant autosomal dominant disorder auxiliary Bacteria balance blood monocyte blood monocytes C57BL/6 cell line characterized conditions contribute deficiency described develop differentiation disorder dominant dysplasia Endoglin endotoxin ENG explain expressed expression foci function help hemorrhage hemorrhages Hereditary Hereditary hemorrhagic telangiectasia homeostasis human cell human macrophages immune immune response Impaired in vitro in vivo increased survival Infection infection rate Infectious disease Infectious diseases Inflammation internal organs knock-out Laboratory leukemic leukemic cell Lineage Macrophage macrophages malformation mice monocyte monocyte-macrophage Monocytes Mortality mouse macrophages multisystemic patients Peripheral blood peripheral blood monocytes peritoneal macrophage peritoneal macrophages peritonitis Phagocytic activity predisposition Prevalence rare disease receptor recruited Rendu-Osler-Weber syndrome response responsible show Signaling surface antigen syndrome target gene Target genes TGF-β TGF-β1 transmembrane protein triggered type I up-regulation Vascular vessel wall was reduced Weber syndrome wild-type
[DOI] 10.1371/journal.pgen.1005935 PMC 바로가기 [Article Type] Research Article

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

기능성 IL6R 358Ala 대립유전자는 전통적인 IL-6 수용체 신호 전달을 손상시키고 다양한 염증성 질환의 위험에 영향을 미칩니다

Research Article

Published on 2013-04-042022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] 358Ala Abdominal aortic aneurysm affecting allele analyzed aortic aneurysm approach Arthritis Asp358Ala association Asthma Atrial fibrillation Author balance benefit Cambridge BioResource causal variant CD4+ T cell CD4+ T cells CHD Chronic diseases circulating cleavage clinical trial clinical trials common diseases complex complex diseases Concentration Control copy Coronary heart disease Critical cytokine diabete diabetes etiology Evidence expression functional Genetic genetic association Genetic variation heart disease human disease identify IL-6 IL-6 receptor IL-6 signaling IL-6R IL-6R signaling IL-6R signaling pathway IL6R Immune cell immune cells impairment implicated implication increase increase in independent Inflammatory Inflammatory responses influence interleukin interleukin-6 isoform mechanism membrane-bound molecular mechanism monocyte Monocytes mononuclear cell mononuclear cells Non-synonymous nucleotide Patient PBMCs Peripheral blood Peripheral blood mononuclear cells Phosphorylation polymorphism Population protein level protein levels RA reduce reduced reduction regulated Regulation rheumatoid arthritis risk rs2228145 Signaling sIL-6R single nucleotide Single nucleotide polymorphism soluble IL-6R Stat1 STAT3 Stimulation suggested surface expression surface receptor susceptibility T cells T1D therapeutic intervention therapy These data Transcription transcription factor transcription factors translate Treatment response Type 1 diabetes variant Variation Volunteer
[DOI] 10.1371/journal.pgen.1003444 PMC 바로가기 [Article Type] Research Article