Autoimmune Diseases and COVID-19 as Risk Factors for Poor Outcomes: Data on 13,940 Hospitalized Patients from the Spanish Nationwide SEMI-COVID-19 RegistryArticle Published on 2021-04-232022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admission Admissions age all-cause mortality Analysis antirheumatic agents Autoimmune disease Autoimmune diseases Barthel Index Biological biological therapy Clinical characteristics Clinical course Comorbidity complications Corticosteroid COVID-19 death decrease diagnosed with COVID-19 disease disease-modifying anti-rheumatic drug Effects Factor female General population Glucocorticoids greater Habitual hospitalized patient ICU immune system diseases in-hospital complications increased risk information intensive care invasive involved mechanical ventilation Mortality multivariate logistic regression Non-invasive Older outcome outcomes Patient patients patients with COVID-19 Poor Primary outcome Prognosis readmission registry SARS-CoV-2 secondary outcome selected Spanish subsequent Treatment variables Weighting with COVID-19 [DOI] 10.3390/jcm10091844 PMC 바로가기 [Article Type] Article
Real-World Methotrexate Dose on Clinical Effectiveness and Structural Damage of Certolizumab Pegol With Rheumatoid ArthritisOriginal Research Published on 2021-04-212024-09-02 Journal: Frontiers in Medicine [Category] 대상포진, [키워드] Biological certolizumab pegol Cytokines DAS28-ESR rheumatoid arthritis X ray [DOI] 10.3389/fmed.2021.643459 PMC 바로가기 [Article Type] Original Research
The Impact of Oral Health on Respiratory Viral InfectionReview Published on 2021-04-132022-10-31 Journal: Dentistry Journal [Category] COVID-19, [키워드] acute respiratory syndrome Affect Bacteria Biological caused complex condition coronavirus Coronavirus disease 2019 COVID-19 feature Health immune Immunity Impact incidence infect Infection Influenza virus Measures mechanism microbiota oral oral cavity organ progression reported respiratory respiratory cells Respiratory disease respiratory infectious disease respiratory viral infection respiratory virus Saliva SARS-CoV-2 secretory immunoglobulin A sialic acid SIgA These viruses thought viral infection virus viruses [DOI] 10.3390/dj9040043 PMC 바로가기 [Article Type] Review
COVID-19 vaccination of patients with allergies and type-2 inflammation with concurrent antibody therapy (biologicals) – A Position Paper of the German Society of Allergology and Clinical Immunology (DGAKI) and the German Society for Applied Allergology (AeDA)Research Article Published on 2021-04-012022-10-28 Journal: Allergologie Select [Category] COVID-19, [키워드] acute respiratory syndrome adjusted allergic allergic reaction allergology allergy antibodies antibody approved Asthma atopic atopic dermatitis atopy Biological Biologicals bronchial asthma caused clinical concomitant treatment condition coronavirus COVID-19 COVID-19 vaccination disease Germany immune stimulation immunological immunomodulatory immunomodulatory drug increased risk indicated Inflammation Inflammatory Interaction interval material monoclonal antibodies nasal paper Patient patients Paul Ehrlich performed potential risk provide Reactions receiving recommendation SARS-CoV-2 SARS-CoV-2 vaccination Society therapy Treatment vaccination Vaccine Vaccines worldwide pandemic [DOI] 10.5414/ALX02241E PMC 바로가기 [Article Type] Research Article
Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients전체 전사체 RNA 시퀀싱은 COVID-19 환자의 말초 혈액에서 유의미하게 차별적으로 발현된 mRNA, miRNA, lncRNA 및 관련 조절 생물학적 경로를 나타냅니다Research Article Published on 2021-04-012022-09-10 Journal: Mediators of Inflammation [Category] MERS, SARS, 유전자 메커니즘, [키워드] “cytokine storm” acute respiratory syndrome acute respiratory syndrome coronavirus AKT1 Analysis Antigen antigen processing Biological biosynthetic characterized China coding collected competing control group controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 sample COVID-19 samples CXCL8 cytokine cytokine production Cytokine storm cytotoxicity diagnostic biomarker Diagnostic biomarkers differentially expressed downregulated enrichment analysis excessive cytokine production FCGR2A Functional enrichment analyses Gene ontology glycogen ground-glass opacity healthy controls healthy donor healthy donors highlight hub genes indicated Inflammation Interaction involved leukocyte leukocytes lncRNA long noncoding RNA lung tissues lymphocyte Lymphocytes mechanism Messenger RNA messenger RNAs microRNA MicroRNAs Migration miRNA miRNAs mRNA mRNAs noncoding RNA Noncoding RNAs pandemic Pathogenesis peripheral Peripheral blood positive potential mechanism potential mechanisms PPI presenting protein-protein interaction Regulating Regulation Regulatory respiratory resulting RNA SARS-CoV-2 selected Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathway Significant significantly STAT3 systemic inflammation T cell T cell activation target the healthy therapeutic tissue TLR2 TNFRSF1B upregulated [DOI] 10.1155/2021/6635925 PMC 바로가기 [Article Type] Research Article
Association of Clinical, Biological, and Brain Magnetic Resonance Imaging Findings With Electroencephalographic Findings for Patients With COVID-19코로나19 환자를 위한 뇌파 검사 소견과 임상, 생물학 및 뇌 자기 공명 영상 소견의 연관성Research Published on 2021-03-152022-09-10 Journal: JAMA Network Open [Category] SARS, 치료기술, [키워드] Abnormalities activities acute respiratory syndrome acute respiratory syndrome coronavirus age analyses Analysis analyzed association awakening Biological biological abnormalities Brain brain MRI Can Central nervous system cerebrospinal fluid Chain Reaction Chest clinical Clinical management cohort of patient cohort study Computed tomography conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 defined delayed awakening delirium detection diagnose Diagnosis disorders Dysnatremia Electroencephalography Electronic patient records Encephalopathy enrolled epileptic events Evidence evidence of exposure feature Features finding France had no help heterogeneous Hospitalization Hospitalized identify imaging impairment Importance indication Infection Injury intensive care intensive care unit ischemic lesions kidney Kidney failure lesions liver dysfunction magnetic resonance imaging Manifestations measure men Movement disorders MRI nasopharyngeal specimen neurologic nonspecific objective Paris participant pathologic Patient patient records patients patients with COVID-19 Pneumonia Point Relevance resonance respiratory Result retrieved retrospective cohort study reverse transcription SARS-CoV-2 Seizure setting severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 syndrome tested Treatment White matter with COVID-19 [DOI] 10.1001/jamanetworkopen.2021.1489 PMC 바로가기 [Article Type] Research
Identifying Biomarkers for Biological Age: Geroscience and the ICFSR Task Force생물학적 연령에 대한 바이오마커 식별: Geroscience 및 ICFSR 태스크포스Special Article Published on 2021-03-082022-09-10 Journal: The Journal of Frailty & Aging [Category] MERS, 바이오마커, [키워드] addressed aging animal model Biological Biomarker Biomarkers branch Cell cellular cellular senescence changes Clinical practice COVID-19 pandemic disability dysfunction Epigenetic force frailty genomic Gerontology Geroscience hallmark hallmarks hallmarks of aging identifying include International Conference Intervention knowledge maintain marker Measures mechanism mitochondrial mitochondrial dysfunction physiological consequence physiological consequences Potential potential biomarkers Prevent priority Proteostasis Research Resilience sarcopenia shadow stem cell target targets Task Force therapy Translational research [DOI] 10.14283/jfa.2021.5 PMC 바로가기 [Article Type] Special Article
COVID-19 in IBD: The experience of a single tertiary IBD centerIBD의 COVID-19: 단일 3차 IBD 센터의 경험Observational Study Published on 2021-03-012022-09-12 Journal: Digestive and liver disease : official journal of [Category] MERS, SARS, 임상, 진단, [키워드] Administered affected analyzed Biological Biological treatment country COVID-*19 COVID-19 died disease General population Hospitalization IBD IBD. Immunosuppressant incidence incidence of COVID-19 Infection Inflammatory bowel disease Italy large cohort majority MOST Patient patients patients treated positive questionnaire required risk factor severity of COVID-19 Symptom tested therapy Treatment Two patient worsening [DOI] 10.1016/j.dld.2020.12.012 PMC 바로가기 [Article Type] Observational Study
Continuation versus discontinuation of renin-angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trialRandomized Controlled Trial Published on 2021-03-012022-10-05 Journal: The Lancet. Respiratory Medicine [Category] SARS, 임상, [키워드] 1:1 Admission adverse event Affect age Analysis Angiotensin receptor blockers Angiotensin-converting enzyme assigned Biological Block randomisation blood pressure concealed contraindication country COVID creatinine death diabetes died enrolled evaluate female Follow-up fundraising had no Hierarchical hospital hospitalisation individual inhibitor inhibitors intensive care intention-to-treat population International Invasive mechanical ventilation mean body-mass index mechanical ventilation median Multiorgan dysfunction no difference Older Open-label outcome participant Patient Potassium Primary outcome randomised Randomly receiving recommendations Registered renal renin-angiotensin system required secure serum Seven severity of COVID-19 therapy treatment group Trial two groups web-based randomisation system were excluded with COVID-19 [DOI] 10.1016/S2213-2600(20)30558-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
Biological activity-based modeling identifies antiviral leads against SARS-CoV-2 Research Published on 2021-02-232022-10-05 Journal: Nature biotechnology [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome anti-SARS-CoV-2 Antiviral antiviral activity applied approach autophagy Biological biological activity Cell culture Compound compounds coronavirus drug candidate Drug discovery Ebola half-maximal inhibitory concentration identify inhibitor ligands Live virus MOST predict predicted profile Quantitative SARS-CoV-2 similarity small molecule Therapies viral entry virus Zika [DOI] 10.1038/s41587-021-00839-1 [Article Type] Research