Group B streptococcus vaccination in pregnant women with or without HIV in Africa: a non-randomised phase 2, open-label, multicentre trial아프리카에서 HIV가 있거나 없는 임산부를 대상으로 한 그룹 B 연쇄상구균 백신: 비무작위 2상, 공개 라벨, 다기관 시험Articles Published on 2016-05-012022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] (no infection adverse event Adverse reaction analysis Analysis Antenatal antibody antibody concentration Antibody concentrations Birth Blood CD4 cell Cell clinics collected Concentration died disease dose enrolled event finding Fold change Follow-up funding geometric geometric mean gestation GlaxoSmithKline group groups HIV HIV infection HIV-uninfected immunogenic immunogenicity increased risk Infant Infants Infection intramuscularly invasive Italy less life maternal antibody Medical Research Council Meningeal mother multicentre Neonate Neonates no infection Novartis Open-label participant Pathogens Phase 2 placental pregnant women Primary outcome Primary outcomes Protective provided recruited reduce Registered reported respiratory resulting safety analyses serotype-specific serotypes serum serum sample Siena South Africa stillborn the vaccine three group three groups transfer transferred Trial trivalent unit vaccination Vaccine Wellcome Trust were measured with HIV women [DOI] 10.1016/S1473-3099(15)00484-3 PMC 바로가기 [Article Type] Articles
Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome중심소체 생합성, Phenocopies Seckel 증후군의 조절자인 마우스 Cenpj의 교란Research Article Published on 2012-11-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Abnormalities addition allele Apoptosis Author Birth Brain cause Cell cell death CENPJ centriole characteristic chromosomal abnormalities chromosomal abnormality chromosome chromosomes clinical feature Clinical features clinical manifestations compared conserved contribute CPAP damaged disorder Disruption DNA damage dwarfism elevated Embryo embryonic embryonic development exhibited expresse expressed feature fibroblast found Frequency Gene genomic growth growth failure hypomorphic immunohistochemistry impairment in addition to Increased J gene lead majority mechanism memory memory impairment Mental mental retardation mice microcephaly mitotic mono mouse Mutation ocular phenocopy proliferation Protein reduced reduction in regulator Seckel Seckel syndrome Signaling skeletal specific mutation specific mutations syndrome wild-type cells [DOI] 10.1371/journal.pgen.1003022 PMC 바로가기 [Article Type] Research Article