Renin-Angiotensin-Aldosterone System Blockers Prior to Hospitalization and Their Association With Clinical Outcomes in Coronavirus Disease 2019 (COVID-19)Cardiology Published on 2021-02-182022-10-31 Journal: Cureus [Category] COVID-19, [키워드] ACE inhibitors ACEi ACEIs Admission age Analysis angiotensin receptor blocker angiotensin-converting enzyme inhibitor ARB ARBs blockade blocker Care clinical Clinical outcome Comorbidities Comorbidity coronavirus disease COVID-19 demographics determine disease severity health system hospital Hospitalization ICU In-hospital death in-hospital mortality intensive care less mechanical ventilation mechanical ventilator Mortality Odds ratio Patient patients RAAS recorded renal function retrospective cohort study severity System Taking The United States [DOI] 10.7759/cureus.13429 PMC 바로가기 [Article Type] Cardiology
A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapyArticle Published on 2021-02-172022-10-04 Journal: Nature Communications [Category] 바이오마커, [키워드] anticipated benefit Biomarker blockade Cancer immunotherapy cancer patient Cancer patients cohort of patients Concentration cytokine demonstrated develop disease elevated higher risk identify immune Immune checkpoint blockade Immune checkpoint inhibitor Immunotherapy improvement indications Inflammatory responses inhibitor life-threatening Melanoma MONITOR Nanobiotechnology Patient platform predict Raman spectroscopy receiving Structural properties subset survival therapy toxicities Toxicity Treatment [DOI] 10.1038/s41467-021-21431-w PMC 바로가기 [Article Type] Article
Infection, inflammation and intervention: mechanistic modelling of epithelial cells in COVID-19Life Sciences–Mathematics interface Published on 2021-02-172022-10-30 Journal: Journal of the Royal Society Interface [Category] COVID-19, MERS, [키워드] acting acute respiratory distress anti-inflammatory agent Asymptomatic carrier biochemical blockade Clinical deterioration Corticosteroids COVID-19 COVID-19 illness current Cytokine storm develop epithelial cell Evidence FIVE hyperinflammation Hyperinflammatory hyperinflammatory state increasingly individual Inflammation Inflammatory response Inhaled inhaled corticosteroids Intervention involved lung mathematical Mild moderate pathological mechanism pathway Patient physiological Prevent pro-inflammatory mediator respiratory compromise SARS-COV-2 infection sensitivity analysis severe COVID-19 disease severe disease Simulation supported syndrome therapeutic intervention trajectory virus while [DOI] 10.1098/rsif.2020.0950 PMC 바로가기 [Article Type] Life Sciences–Mathematics interface
VISTA: A Target to Manage the Innate Cytokine StormVISTA: 타고난 사이토카인 폭풍을 관리하기 위한 표적Review Published on 2021-02-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] agonistic antibodies Anti-inflammatory Antigen presentation Autoimmune diseases blockade Cancer canonical marker canonical markers CD14 CD16 Cell change Complete conserved COVID-19 cytokine Cytokine storm Cytokine storms Diseases driven by dysregulated immune response expression Fcγr3a focus highlight human monocyte human monocytes Hyperinflammatory response IFN-I immune immune checkpoint immune responses immune system Immunity Immunosuppression Immunotherapy implication Inflammatory responses inhibitory Innate monocyte reprogramming Monocytes myeloid myeloid cell myeloid cells offer pathogenic pathology pathway Pathways phenotype receptor related diseases storm Support suppress T cell T cell activation target the interferon therapeutic triggering unique Viral viral infection viral infections vista while [DOI] 10.3389/fimmu.2020.595950 PMC 바로가기 [Article Type] Review
Dynamic angiopoietin-2 assessment predicts survival and chronic course in hospitalized patients with COVID-19동적 안지오포이에틴-2 평가는 COVID-19로 입원한 환자의 생존 및 만성 경과를 예측합니다Article Published on 2021-02-092022-09-11 Journal: Blood advances [Category] MERS, 바이오마커, 진단, 치료제, [키워드] 95% CI 95% confidence interval Accuracy alveolar Analysis angiopoietin Area association AUROC baseline Biomarker blockade CD34 CD68 change characteristic Clinical course Cohort Computed tomography Computed tomography scans Course COVID-19 Cox model disease pathogenesis dynamic enzyme-linked immunosorbent enzyme-linked immunosorbent assay examined Follow-up hazard ratio hospitalized patient identify in-hospital mortality interstitial thickening Italian laboratory-confirmed Laboratory-confirmed COVID-19 lung tissue macrophages Mortality Multivariate analysis Patient patients predict receiver operating characteristic receiver operating characteristic curve risk factor Risk factors significantly survival tissue Treatment validation cohort vessel was used were measured with COVID-19 [DOI] 10.1182/bloodadvances.2020003736 PMC 바로가기 [Article Type] Article
Management of Renin-Angiotensin-Aldosterone System blockade in patients admitted to hospital with confirmed coronavirus disease (COVID-19) infection (The McGill RAAS-COVID- 19): A structured summary of a study protocol for a randomized controlled trial코로나바이러스 감염증(COVID-19) 감염이 확인된 병원에 입원한 환자의 레닌-안지오텐신-알도스테론 시스템 차단 관리(The McGill RAAS-COVID-19): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Study Protocol Published on 2021-02-052022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 48 hour 48 hours ACE inhibitor ACE2 Acute kidney injury Admission age aldosterone All participants Amendment Analysis Anticoagulants approach assigned baseline Biomarker Biomarkers blinded Blinding blockade blood pressure BNP C-reactive protein C-reactive protein (CRP calculated calibrated cardiovascular disease change Clinical improvement clinical trials collected comparator component Consent coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 infection COVID-19 patient creatinine creatinine) CRP database death diagnosis of COVID-19 died discharge dissemination domains doubling Effect EGFR Ejection fraction element eligible Endpoint enrolment Estimated Ethnicity evaluate event exclusion criteria feasibility Follow-up followed by General Hospital greater groups Health Health Organization heart failure high blood pressure highest hospital ICU ICU admission immunopathology include Inclusion inclusion and exclusion criteria increase increase in Increases indicate Infection inhibitor inhibitors initial initiated intervention arm intravenous invasive ventilation list Lower lowest lymphocyte Lymphocyte count lymphocyte counts mathematical mathematical model McGill University mean rank mechanical ventilation medical history medication medications meet Montreal Mortality number objective Older open open label Ordinal Scale outcome outcomes participant Participants past medical history Patient patient cohort PCR performed Prevent primary end point primary endpoint Protein protocol provided RAAS RAAS inhibitor random number generator randomised randomised controlled trial randomization Randomized Randomized controlled trial recruitment reduced Registration Renin required Sample Sample size SARS- CoV2 secondary secondary endpoint sensitivity sensitivity analysis serum creatinine Sex short term stability statistical power calculations status stroke study participant Study protocol subsequent supplementary material System table team the patient the primary endpoint therapy transfer transferred Treatment Trial troponin Version Victoria ward website were excluded WHO withdrawn World Health Organization [DOI] 10.1186/s13063-021-05080-4 PMC 바로가기 [Article Type] Study Protocol
Sensitive mass spectrometric determination of kinin-kallikrein system peptides in light of COVID-19Article Published on 2021-02-042022-10-04 Journal: Scientific Reports [Category] MERS, 치료기술, [키워드] activate Adsorption alteration assays Biomarkers blockade cough COVID-19 cross-reactivity Degradation determine drug effort European food impede increasingly limit Medicine nasal non-specific other diseases outbreak pathophysiology peptide promote inflammation quantification raised receptor Regulatory Respiratory tract diseases sensitive sensitivity Support [DOI] 10.1038/s41598-021-82191-7 PMC 바로가기 [Article Type] Article
A novel screening strategy of anti-SARS-CoV-2 drugs via blocking interaction between Spike RBD and ACE2Spike RBD와 ACE2 간의 상호 작용 차단을 통한 항 SARS-CoV-2 약물의 새로운 스크리닝 전략Article Published on 2021-02-012022-08-31 Journal: Environment international [Category] MERS, SARS, 치료제, [키워드] ACE2 activity angiotensin angiotensin converting enzyme anti-SARS-CoV-2 Anti-SARS-CoV-2 drugs screening strategy binding binding energy blockade Blockade mechanism Compound compounds Corona drug drug design Drug screening druggability eight enzyme exhibited hACE2 hesperidin highest human angiotensin converting enzyme 2 information Interaction investigated mechanism overcome pandemic RBD Receptor binding domain required S RBD SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 Spike RBD screening strategy spike Spread Structure Structure-activity relationship structures therapy Virus Disease [DOI] 10.1016/j.envint.2020.106361 PMC 바로가기 [Article Type] Article
[Fatal course of COVID-19 despite IL-6 receptor blockade in cytokine storm : Perimyocarditis and coagulopathy after administration of tocilizumab][사이토카인 폭풍에서 IL-6 수용체 차단에도 불구하고 코로나19의 치명적인 경과 : 토실리주맙 투여 후 심근주위염 및 응고병증]Case Reports Published on 2021-02-012022-09-11 Journal: Anaesthesist [Category] 진단, 치료제, [키워드] Administered administration Admission ARDS Azithromycin blockade can not Cardiac arrhythmia circulatory shock Clinical deterioration Coagulopathy Course COVID-19 criteria cytokine Cytokine storm diagnosed died ECMO Efficacy English Exacerbation hemodynamic instability hospital Hydroxychloroquin Hydroxychloroquine IL-6 receptor inflammation marker initiated lAbel male moderate multiorgan failure occurred off-label Patient patient selection Perimyocarditis Pneumonia Randomized controlled studies receptor receptor antagonist respiratory insufficiency second dose Shock Tage the patient Tocilizumab Treatment treatment with tocilizumab with COVID-19 worsened [DOI] 10.1007/s00101-020-00871-x PMC 바로가기 [Article Type] Case Reports
CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14중요한 COVID-19 환자의 CCR5 억제는 염증성 사이토카인을 감소시키고 CD8 T 세포를 증가시키며 14일째까지 혈장에서 SARS-CoV2 RNA를 감소시킵니다Article Published on 2021-02-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed antibody baseline blockade CCR5 CD4/CD8 CD8 changes in Clinical efficacy Complete coronavirus correlated COVID-19 critical COVID-19 patient decrease discharged Donor dose dysregulated immune response Emergency use global pandemic IL-6 Immune cell immune cell populations immunological Immunotherapy increase increase in Inference Inflammation Inflammatory cytokines investigated Leronlimab Migration over parameter Patient plasma Plasma viral load. randomized clinical trials Receptor occupancy reduction in respiratory restoration RNA SARS-CoV-2 SARS-CoV2 severe acute respiratory syndrome Coronavirus severe COVID-19 patients statistically significant reduction Study design study period survived T-cells therapeutic target Treatment Viral Viral load Viremia Virological [DOI] 10.1016/j.ijid.2020.10.101 PMC 바로가기 [Article Type] Article