Bronchoalveolar lavage – Page 11 – Communicable Diseases Research

Bronchoalveolar lavage-based COVID-19 testing in patients with cancer

Case Report

Published on 2021-03-012023-06-19
Journal: Hematology/oncology and stem cell therapy [Category] MERS, SARS,

A Novel DNA Vaccine Against SARS-CoV-2 Encoding a Chimeric Protein of Its Receptor-Binding Domain (RBD) Fused to the Amino-Terminal Region of Hepatitis B Virus preS1 With a W4P Mutation

W4P 돌연변이가 있는 B형 간염 바이러스 preS1의 아미노 말단 영역에 융합된 수용체 결합 도메인(RBD)의 키메라 단백질을 암호화하는 SARS-CoV-2에 대한 새로운 DNA 백신

Immunology

Published on 2021-02-262022-09-11
Journal: Frontiers in Immunology [Category] MERS, 변종, 진단,

[키워드] Against BAL Blood Bronchoalveolar lavage caused cell-mediated immune response Cellular immune response chimeric coronavirus coronavirus SARS-CoV-2 COVID-19 demonstrated develop disease DNA DNA vaccine domain effective encoding evaluated experiment expressing feasibility fused global public health HBV HBV preS1 hepatitis B Hepatitis B virus highlighting humoral IgA IgG IL-6 immune responses Infection lung mice multiple cell line Mutation N-terminal neutralize novel pandemic Pneumonia PROTECT Protein RBD RBD protein Receptor-binding domain Receptor-binding domain (RBD) Region robust S1 protein Safe SARS-CoV-2 SARS-COV-2 infection sequence sera significantly TNFα Transcription translation Vaccine Viral Viral pneumonia W4P-RBD wild-type
[DOI] 10.3389/fimmu.2021.637654 PMC 바로가기 [Article Type] Immunology

Clonal expansion and activation of tissue-resident memory-like T H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19

중증 COVID-19 환자의 폐에서 GM-CSF를 발현하는 조직 상주 기억 유사 T H 17 세포의 클론 확장 및 활성화

Research Article

Published on 2021-02-232022-09-12
Journal: Science Immunology [Category] Fulltext, MERS, 진단,

[키워드] Activation acute respiratory distress acute respiratory distress syndrome Analysis Autoimmune diseases Bacterial bacterial pneumonia BAL Blood Bronchoalveolar lavage Bronchoalveolar lavage fluid CD8 Cell cell type cells cellular characterized Clinical course clonal expansion clone Cohort cohort of patient collected contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia CSF2 cytokine cytokine expression profile disease severity elevated expressing feature Generation GM-CSF helper high mortality hyperinflammation identify IL-17A IL17A Immune cell immune cell type immune cells immune response Immunopathogenesis interactome investigated involved lung lung damage Lung injury Lung pathology lung tissue Lungs Macrophage macrophages mechanism memory T cell moderate disease pathogenic Patient patients with COVID-19 Pneumonia protein level pulmonary T respiratory distress Respiratory distress syndrome serum severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia single-cell subsequent syndrome T cell T cell response T cells T helper TCR Th17 cells Therapies tissues Transcriptome Viral viral clearance viral infection
[DOI] 10.1126/sciimmunol.abf6692 PMC 바로가기 [Article Type] Research Article

Not COVID-19, Don’t Overlook Pneumocystis in Patients on Gefitinib!

Case Report

Published on 2021-02-212022-10-31
Journal: Current Oncology [Category] COVID-19, MERS,

Performance of Low-Dose Chest CT as a Triage Tool for Suspected COVID-19 Patients

Original Article

Published on 2021-02-162022-10-30
Journal: Journal of the Belgian Society of Radiology [Category] COVID-19,

Direct antivirals working against the novel coronavirus: azithromycin (DAWn-AZITHRO), a randomized, multicenter, open-label, adaptive, proof-of-concept clinical trial of new antivirals working against SARS-CoV-2—azithromycin trial

신종 코로나바이러스에 대항하는 직접 항바이러스제: 아지스로마이신(DAWn-AZITHRO), 무작위, 다기관, 공개 라벨, 적응형, SARS-CoV-2에 대해 작용하는 새로운 항바이러스제의 개념 증명 임상 시험 - 아지스로마이신 시험

Study Protocol

Published on 2021-02-092022-09-10
Journal: Trials [Category] MERS, 임상, 치료제,

[키워드] 7-category ordinal scale adaptive Admission amplify antibiotic Antiviral Antiviral effect Azithromycin Belgium blunt Bronchoalveolar lavage Care chance chest CT scan clinical Clinical improvement clinical trial coronavirus SARS-CoV-2 Course COVID COVID-19 COVID-19 disease cytokine cytokine signaling decrease defined diagnosed with COVID-19 Diagnosis Direct discharge disease disease course drug Efficacy eligible EudraCT feature health regulations Hospitalized hospitalized patient hospitalized patients Hydroxychloroquine hyperinflammatory state immunomodulatory properties implicated in vitro include Inclusion Intervention life Local Macrolide medical need multicenter name Nasopharyngeal swab National Novel coronavirus novel coronavirus SARS-CoV-2 Open-label Ordinal Scale pathway Pathways Patient patients patients with COVID-19 PCR Phase 2 Primary outcome proof-of-concept clinical trial radiological Randomized Randomized controlled trial receive recruit SARS-CoV-2 severe COVID-19 disease shown Standard Standard of care study inclusion supplementary material Support sustained symptomatic the disease the WHO treatment effect treatment effects treatment group treatment strategy Trial Viral viral replication widespread with COVID-19
[DOI] 10.1186/s13063-021-05033-x PMC 바로가기 [Article Type] Study Protocol

Localized and Systemic Immune Responses against SARS-CoV-2 Following Mucosal Immunization

Article

Published on 2021-02-062022-10-28
Journal: Vaccines [Category] COVID-19,

SARS-CoV-2 diagnostics in the virology laboratory of a University Hospital in Rome during the lockdown period

폐쇄 기간 동안 로마에 있는 대학 병원의 바이러스 연구소에서 SARS-CoV-2 진단

Article

Published on 2021-02-012022-09-11
Journal: Journal of medical virology [Category] Fulltext, MERS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affected age Analysis analyzed Bronchoalveolar lavage cerebrospinal cerebrospinal fluid China confirmed case continuous surveillance coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 diagnostics Epidemiology Evolution fluids gargle highlighting individuals Infection infections information Italian regions Italy Laboratory laboratory diagnostics. lockdown male nasopharyngeal swabs pandemic Patient pleural fluids positive result reached respiratory Respiratory samples Rome SARS-CoV-2 SARS-CoV-2 epidemiology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Sex single-center specimen spread to Stool stools subject Surveillance tested university Variation Virology virus
[DOI] 10.1002/jmv.26332 PMC 바로가기 [Article Type] Article

Hydroxychloroquine lung pharmacokinetics in critically ill patients with COVID-19

COVID-19 중환자의 하이드록시클로로퀸 폐 약동학

Observational Study

Published on 2021-02-012022-09-11
Journal: International journal of antimicrobial agents [Category] 임상, 치료제,

[키워드] (coronavirus disease 2019 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered BAL Bronchoalveolar lavage bronchoalveolar lavage sample bronchoalveolar lavage samples cause Clinical practice collected Concentration conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients Critically ill patient dosage evaluate HCQ hospital Hydroxychloroquine increase in induce infected with SARS-CoV-2 information interquartile range Intervention intubated COVID-19 patient lung lung epithelial median multicentre nasogastric tube Patient patients pharmacokinetic plasma plasma concentration Plasma drug monitoring. regimen respiratory retrospective severe acute respiratory syndrome Coronavirus standard care tablets treated virus with COVID-19
[DOI] 10.1016/j.ijantimicag.2020.106247 PMC 바로가기 [Article Type] Observational Study

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

기관지폐포 세척액의 선천적 및 적응 면역 단일 세포 프로파일링을 통해 심각한 COVID-19와 경증 구별

Article

Published on 2021-01-212022-09-12
Journal: Cell Research [Category] 유전자 메커니즘, 임상, 진단, 치료기술,