Estimates and Determinants of SARS-Cov-2 Seroprevalence and Infection Fatality Ratio Using Latent Class Analysis: The Population-Based Tirschenreuth Study in the Hardest-Hit German County in Spring 2020SARS-COV-2 Seroprevalence 및 감염 사망률 비율의 추정 및 결정 요인 잠재 계급 분석 : 2020 년 봄 가장 어려운 독일 카운티에서 인구 기반 Tirschenreuth 연구Article Published on 2021-06-102022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] accounted age Analysis analyzed antibodies antibody tests Care case fatality ratio CFR class CLIA computation conducted deaths determinant ELISA estimate Factor fatality IFR implication individual Infection infection fatality ratio infections Latent latent class analysis Measures molecular cause outbreak participant proportion Ratio reflected Registered SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection senior care homes Seroprevalence severe SARS severe SARS-CoV-2 smoker Smokers smoking spring suffered underreported infections while [DOI] 10.3390/v13061118 PMC 바로가기 [Article Type] Article
Transport of Aerosols in Underground Mine Workings in Terms of SARS-CoV-2 Virus ThreatSARS-COV-2 바이러스 위협 측면에서 지하 광산 작업에서 에어로졸의 운송Article Published on 2021-06-082022-08-31 Journal: Molecules [Category] MERS, SARS, 치료제, [키워드] aerosol aerosol transmission Aerosol transport Aerosols carried class Concentration conditions Consumption coronavirus Coronavirus infection cubic determine distance generator implementation Infection Mining ventilation Numerous parameter Particle potential risk Relative humidity SARS-CoV-2 SARS-CoV-2 coronavirus selected solution temperature term threat Transmission Underground mines Ventilation working [DOI] 10.3390/molecules26123501 PMC 바로가기 [Article Type] Article
Profiles of Depressive Symptoms Among Men Who Have Sex With Men and Transgender Women During the COVID-19 Outbreak in Mexico: A Latent Class AnalysisPublic Health Published on 2021-06-072022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, [키워드] Analysis Anxiety applied association caused center Characteristics class conducted COVID-19 COVID-19 outbreak COVID-19 pandemic Depression depressive symptom Depressive symptoms FIVE high-risk population highlight HIV identify Impact Latent latent class Logistic regression men men who have sex with men mental health Mexico multivariate National participant posterior probability Prevalence profile Psychological intervention risk scale Sex Stress Transgender women [DOI] 10.3389/fpubh.2021.598921 PMC 바로가기 [Article Type] Public Health
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions약물 용도 스크린 스크린은 Covid-19 개입의 개발을위한 화학 기관을 식별합니다.Article Published on 2021-06-032022-08-31 Journal: Nature Communications [Category] MERS, SARS, 변종, 신약개발, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity block Calu-3 calu-3 cells candidate caused Cell cell line cell lines class combination therapies Compound compounds coronavirus COVID-19 direct-acting antiviral Direct-acting antivirals drug library Drug repurposing expressing hamsters HeLa cell HeLa cells high-content imaging High-throughput screening Host host cell identify in vitro activity Infection inhibiting inhibitors inhibitors of SARS-CoV-2 Intervention lung epithelial mechanism nelfinavir pandemic parent pharmacokinetic primary cell prodrug profiles Prophylactic receptor ACE2 reduce respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 replication sensitivity targets therapeutic drug Viral viral infection virus entry [DOI] 10.1038/s41467-021-23328-0 PMC 바로가기 [Article Type] Article
Drug repurposing of selective serotonin reuptake inhibitors: Could these drugs help fight COVID-19 and save lives?선택적 세로토닌 재흡수 억제제의 약물 용도 변경: 이 약물이 COVID-19와 싸우고 생명을 구하는 데 도움이 될 수 있습니까?Review Published on 2021-06-012022-08-31 Journal: Journal of clinical neuroscience : official journa [Category] MERS, 신약개발, 치료제, [키워드] 2019 novel coronavirus absence Affect Anti-inflammatory antidepressant Antidepressant drugs antiviral properties attenuate CCL-2 class clinical trials confirmed case coronavirus disease COVID-19 COVID-19 patients curative treatment Cytokines death disease drug Drug repurposing effective Emerging infectious disease Evidence Fluoxetine focus help identify IL-6 immune system immunomodulatory Infectious disease life management mental health morbidity Neurological complication Neurological complications Novel coronavirus novel coronavirus disease pandemic present pro-inflammatory Quality of life reduce reducing reported Safe SARS-CoV-2 selective Selective serotonin reuptake inhibitors (SSRIs). Serotonin serotonin reuptake inhibitor serotonin reuptake inhibitors tested therapeutic therapeutic agent therapeutic strategy TNF-α Tolerability Vaccine widespread [DOI] 10.1016/j.jocn.2021.03.010 PMC 바로가기 [Article Type] Review
A data driven change-point epidemic model for assessing the impact of large gathering and subsequent movement control order on COVID-19 spread in Malaysia말레이시아의 COVID-19 확산에 대한 대규모 집회 및 후속 이동 통제 명령의 영향을 평가하기 위한 데이터 기반 변경점 전염병 모델Research Article Published on 2021-05-272022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, [키워드] Analysis Asymptomatic Bayesian framework capture class contributed Control country COVID-19 COVID-19 case COVID-19 cases develop disease disease spread effective Effectiveness Epidemic Government heterogeneous implementation Inference Intervention introduced Local Malaysia mathematical Mathematical models methodology Ministry of Health movement NPI NPIs provided Quantitative quantitative assessment reached reduce reported second wave SEIR Spread spread of COVID-19 starting statistical analysis subsequent the disease Transmission transmission rate transmission rates variant [DOI] 10.1371/journal.pone.0252136 PMC 바로가기 [Article Type] Research Article
Biological responses to COVID-19: Insights from physiological and blood biomarker profilesCOVID-19에 대한 생물학적 반응: 생리학적 및 혈액 바이오마커 프로필에서 얻은 통찰력Article Published on 2021-05-012022-08-31 Journal: Current research in translational medicine [Category] MERS, SARS, 바이오마커, [키워드] accompanied Admission adverse outcomes Analysis baseline best Biological biological response biological responses Biomarker Biomarkers Blood C-reactive protein Characteristics class Classes collected Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 Course COVID-19 CRP death declined elevated empirical evidence Evidence except for exhibited FIVE heterogeneous highest hospitalised Hyperinflammatory Hyperinflammatory response Implications Inflammation Inflammatory Inflammatory response insight intensive care kidney Kidney injury laboratory-confirmed Laboratory-confirmed COVID-19 Latent latent profile analysis lowest male measure median age mortality rate mortality risk neutrophil neutrophil counts older patients pathophysiology Patient performed physiological Platelet Platelet count profile provide provided renal renal failure response retrospective cohort study rising SARS-CoV-2 severe COVID-19 Spectrum targeted therapy therapeutic understanding unique was performed white cell [DOI] 10.1016/j.retram.2021.103276 PMC 바로가기 [Article Type] Article
A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trialSARS-CoV-2 유발 급성 호흡곤란 증후군에 대한 정맥내 혈장 정제 알파-1 항트립신의 무작위 이중 맹검 위약 대조 파일럿 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-192022-09-10 Journal: Trials [Category] 임상, [키워드] 24 hours active malignancy acute kidney Acute kidney injury acute respiratory distress syndrome addition Administered administration adverse event adverse events AEs age Alpha alpha-1 antitrypsin Amendment Anti-viral Antibiotics anticipated antitrypsin antivirals approval approved ARDS ARMS authority bacterial pneumonia baseline Berlin criteria blinded to treatment Blinding BMI body weight Cancer changes in Child-Pugh score chloride Chronic kidney disease chronic liver disease circulating class clinical Clinical outcome clinical trial Combination commenced Committee comparator Complete conducted Consent Controlled trial correction COVID-19 Culture cytokine level cytokine levels Data collection defined determine Diagnosis diagnosis of ARDS dialysis dissemination DNAR double-blind Echocardiogram Effect Effectiveness elapsed element ELISA enrolled EudraCT excluded exclusion exclusion criteria facilitate Follow-up followed by for inclusion group Health Products regulatory Authority hospital Hospital admission hypertension ICU IgA deficiency IL-10 IL-1β IL-6 IL-8 incidence inclusion criteria individual information intensive care unit intensive care units interim analysis interleukin interleukin-10 interleukin-1β interleukin-6 interleukin-8 interpreter Intervention intravenous intravenous infusion intravenously invasive investigational medicinal product investigator Ireland Kidney disease Laboratory laboratory-confirmed life Local maintain major trauma malignancy mandatory marker mechanical ventilation Microscopy moderate moderate to severe Mortality Non-invasive non-invasive mechanical ventilation non-invasive ventilation number objective occur Organ failure outcome outcome measure PaO participant Patient patient recruitment patients with moderate PCR-confirmed Phase 2 physician Placebo placebo-controlled plasma plasma analysis plasma concentration plasma concentrations pregnant preparation product protocol provided Pulmonary embolism pulmonary hypertension purified Radiographic randomisation randomisation list randomised randomised controlled trial rationale readmission REC receiving receptor recruited recruitment reduce Regulatory removal renal renal replacement therapy replacement therapy reported required Research Research Ethics Research Ethics Committee research nurse research nurses respiratory respiratory distress Respiratory distress syndrome resulting Resuscitation SAE SAEs Sample size SARS-CoV-2 secondary secondary bacterial pneumonia Secondary objective Secondary objectives Secondary outcomes secretion Sequential Organ Failure Assessment Serious Adverse Event Serious Adverse Events severe ARDS Shock single dose skin cancer Sodium chloride SOFA Standard statistician stratified study participation Study protocol subject submitted supplementary material Support sustained TNF TNF-α Tolerability trauma Treatment treatment allocation Trial trial protocol Trial registration vasopressors ventilator verbal Version Volume website WHO Withdrawal writing [DOI] 10.1186/s13063-021-05254-0 PMC 바로가기 [Article Type] Letter
Interferon-Independent Restriction of RNA Virus Entry and Replication by a Class of Damage-Associated Molecular PatternsResearch Article Published on 2021-04-132022-10-29 Journal: mBio [Category] Coronavirus, SARS, [키워드] activities activity Antiviral antiviral action antiviral activity antiviral response Cell cell lysis cells class damage-associated molecular pattern damaged cells DAMP DAMPs dead Defense detect disrupt engage event Host human epithelial cells include induce Infection Inflammatory Influenza virus Innate immunity interferon response limit Lipid lipids lung mechanism microbial oxidized oxPAPC oxygenated PAMP PAMPs pathogen-associated molecular pattern pattern Phosphatidylcholine Prevent promote inflammation released response responses restriction RNA RNA virus SARS SARS-CoV-2 stimulate subject Support the interferon tissue damage vesicular stomatitis virus viral entry viral growth Viral load viral replication virus VSV [DOI] 10.1128/mBio.00584-21 PMC 바로가기 [Article Type] Research Article
Dissemination of Aerosol and Splatter in Clinical Environment during Cavity Preparation: An In Vitro StudyArticle Published on 2021-04-042022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] aerosol Anxiety assistant Cavity Cellulose Chest class clinical clinical environment collected college conducted contagious infection Contamination COVID-19 dental dental manikin dental personnel dentistry Environment evaluate Faisal Grade 1 Health care worker infection control investigator King Laboratory operator Particle patients produced Protective reduce replaced risk second set social distancing Splatter Spread statistically significant difference suction the mean the patient tooth university upper leg Volume was done was performed was used were used [DOI] 10.3390/ijerph18073773 PMC 바로가기 [Article Type] Article