Infectious complications, immune reconstitution, and infection prophylaxis after CD19 chimeric antigen receptor T-cell therapy Reviews Published on 2022-07-152022-10-05 Journal: Bone marrow transplantation [Category] 치료제, [키워드] CAR CD19 Cell chimeric antigen receptor clinically complications Cytokine release syndrome disease Evidence Factor hematologic Hypogammaglobulinemia immune immune function incidence increasingly Infection less lymphoid malignancies Patient patients Prophylaxis recipient risk factor Side effect standard treatment T-cell T-cells therapy Treatment undergo Vaccination strategy [DOI] 10.1038/s41409-022-01756-w [Article Type] Reviews
Real-time allelic assays of SARS-CoV-2 variants to enhance sewage surveillance하수 감시를 강화하기 위한 SARS-CoV-2 변이체의 실시간 대립유전자 분석Article Published on 2022-07-152022-09-11 Journal: Water research [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] allele Allele-specific RT-qPCR allelic Alpha Analysis Beta Beta variant clinically Community sewage Concordance COVID-19 patient cross-reactivity Delta delta variant diagnosed discharged eight ENhance Gamma genotypes Hong Kong integration Lambda offer omicron Omicron variant outbreak provided qPCR quarantine real-time RT-qPCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sequence sewage Sewage surveillance specificity Surveillance variant variants Viral RNA whole-genome sequencing [DOI] 10.1016/j.watres.2022.118686 PMC 바로가기 [Article Type] Article
Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants파지 디스플레이가 조작한 펩티드-항체 융합은 SARS-CoV-2 변이체의 초강력 및 광범위한 중화를 나타냅니다Article Published on 2022-07-152022-09-11 Journal: ACS chemical biology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] affinities affinity approach approved B.1.1.529 Bivalent bivalent IgG breadth clinically Coverage COVID-19 demonstrated display domain dominant ENhance exacerbated fused fusion fusions generate implicated IMPROVE Infection infection assay low potency Mutation N-terminal domain N-terminus NAb NAbs naïve neutralization neutralization potency neutralize neutralizing antibody NTD omicron peptide peptides phage RBD RBD mutation RBD mutations S-protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein spread of COVID-19 tetravalent the RBD the spike protein therapeutic Therapeutics trimer variant variants variants of concern vulnerability [DOI] 10.1021/acschembio.2c00411 PMC 바로가기 [Article Type] Article
Suppression of Pituitary Hormone Genes in Subjects Who Died From COVID-19 Independently of Virus Detection in the Gland샘에서 바이러스 검출과 독립적으로 COVID-19로 사망한 피험자의 뇌하수체 호르몬 유전자 억제Article Published on 2022-07-142022-09-11 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] ACTH adrenocorticotropic adrenocorticotropic hormone Antigen antigens cardiac death Cell Chain Reaction changes in clinically controls COVID-19 COVID-19 case COVID-19 group cytotoxic cell death deficiency detection died direct viral infection dysfunction evaluate exploration expression Gene Expression Genes gland hormone Hormones hospitalized patients hypophysis immune immunohistochemistry In situ hybridization investigated Involvement Level mRNA transcript mRNA transcripts neurohypophysis neutrophil Patient PCR Pituitary pituitary apoplexy pituitary gland pituitary hormone pituitary hormones. polymerase chain polymerase chain reaction Real-Time Reverse Transcription Polymerase Chain Reaction reverse transcription SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection searched serum severe COVID-19 Signaling subject sudden cardiac death suggested Support suppressed suppression the SARS-CoV-2 genome transmission electron microscopy trauma tropism tropism of SARS-CoV-2 type I interferon Viral viral genome viral infection virus were measured [DOI] 10.1210/clinem/dgac312 PMC 바로가기 [Article Type] Article
Transitioning from Intravenous to Subcutaneous Vedolizumab in Patients with Inflammatory Bowel Disease [TRAVELESS]염증성 장 질환 환자에서 정맥 주사에서 피하 베돌리주맙으로 전환 [TRAVELESS]Article Published on 2022-07-142022-09-12 Journal: Journal of Crohn's & colitis [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adverse drug reactions appear baseline benefit biochemical bowel calprotectin clinically Cohort cohort of patients declining Disease activity dose effective evaluate expected Health Service IBD increase in Inflammatory bowel disease injection intravenous measure offered outcome Patient Patient satisfaction reaction reason reduction reported risk factor routine clinical care Safe SARS-COV-2 infection statistically significant statistically significant difference Subcutaneous switching TRAVELESS Treatment unlikely vedolizumab Week [DOI] 10.1093/ecco-jcc/jjab224 PMC 바로가기 [Article Type] Article
Rapid self-test of unprocessed viruses of SARS-CoV-2 and its variants in saliva by portable wireless graphene biosensor휴대용 무선 그래핀 바이오센서를 통한 타액 내 처리되지 않은 SARS-CoV-2 바이러스 및 그 변이체의 신속한 자가 테스트Article Published on 2022-07-122022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus aptamer biosensor clinically Cognate Concentration coronavirus COVID-19 D614G detect determined by diagnostic DNA domain early phase environmental monitoring epidemiological epidemiologically field-effect transistor Graphene limit limit of detection LoQ MERS Middle East Middle East respiratory syndrome N protein N501Y nucleocapsid omicron pandemic plaque plaque-forming unit platform positive Precision Protein Proteins public health quantitation Rapid RBD Receptor-binding domain respiratory RT-PCR S protein Saliva saliva samples SARS-CoV-2 SARS-CoV-2 variant sensitivity sensor severe acute respiratory syndrome coronavirus 2 significantly lower specificity Spike protein statistically variant variants of concern viral particle Viral particles Viral proteins virus Y453F [DOI] 10.1073/pnas.2206521119 PMC 바로가기 [Article Type] Article
Validation of remote height and weight assessment in a rural randomized clinical trialRandomized Controlled Trial Published on 2022-07-112022-10-05 Journal: BMC Medical Research Methodology [Category] 임상, [키워드] analyses Analysis BMI body mass body mass index children clinical clinical trial clinical trials clinically coefficient conducted difference examined family feasible Height Impact mean difference measure pandemic protocol provided randomized clinical trial ranged remote Remote assessment Result rural Trial validation weight [DOI] 10.1186/s12874-022-01669-8 PMC 바로가기 [Article Type] Randomized Controlled Trial
Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study중요한 COVID-19에서 정맥내 IgM이 풍부한 면역글로불린: 다기관 성향 가중 코호트 연구Multicenter Study Published on 2022-07-072022-09-12 Journal: Critical Care [Category] COVID19(2023년), SARS, 진단, [키워드] 30-Day mortality acute respiratory distress addition applied Characteristics clinical clinically Cohort cohort study Complication concerning confidence interval controls coronavirus disease COVID-19 COVID-19 patients Cox regression models Critical Critically ill Critically ill patient daily dose dose early administration Effect Efficacy high mortality ICU ICU Patients Immunoglobulin immunoglobulin M immunoglobulins Inflammatory intravenous laboratory-confirmed Lung injury mechanical ventilation mechanically ventilated Mortality multicentre overcome Patient Primary outcome randomization randomized clinical trials retrospective SARS-CoV-2 selection bia statistical significance statistically statistically significant difference subgroup analysis subgroups survival treated Treatment treatment regimen two group was performed Weighting with COVID-19 [DOI] 10.1186/s13054-022-04059-0 PMC 바로가기 [Article Type] Multicenter Study
Effect of treatment interruptions and outcomes in cancer patients undergoing radiotherapy during the first wave of COVID-19 pandemic in a tertiary care instituteObservational Study Published on 2022-07-042022-10-05 Journal: Journal of the Egyptian National Cancer Institute [Category] 임상, [키워드] Analysis Cancer cancer patient Care clinically cohorts of patients Comorbidities conducted COVID-19 COVID-19 pandemic COVID-19 patient disease Disease progression Effect effect of treatment eligible patient First wave Follow-up fraction Fractions general condition Immunosuppression impacted India less material Observational cohort study outcome outcomes Patient patients patients died patients treated positive Primary outcome Radiation radiation therapy Radiotherapy recovering from COVID-19 reported retrospective significant difference the patient Treatment Treatment interruption Treatment outcome treatment outcomes two groups [DOI] 10.1186/s43046-022-00129-0 PMC 바로가기 [Article Type] Observational Study
The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals Research Published on 2022-07-022022-10-05 Journal: The Pharmacogenomics Journal [Category] 유전자 메커니즘, [키워드] alleles chromosome 10 clinically compounds CYP2C8 CYP2C9 cytochrome P450 enzyme drug drugs exhibit genes encoding Haplotype influence Linkage disequilibrium locus metabolism reduced therapeutic doses Toxicity Variation [DOI] 10.1038/s41397-022-00284-6 [Article Type] Research