Mental health implications of COVID-19 pandemic and its response in IndiaReview Articles Published on 2020-09-012022-10-30 Journal: The International Journal of Social Psychiatry [Category] COVID-19, MERS, [키워드] Anxiety approach articles Care combinations COVID-19 COVID-19 pandemic database Depression Epidemiology Evidence Government of India Health illness implication increasingly independent India Insomnia Intervention Keeping measure media mental health mental health issue Older organizations pandemic positive Psychological reactive reported resource risk SARS-CoV-2 Stress Treatment website [DOI] 10.1177/0020764020950769 PMC 바로가기 [Article Type] Review Articles
Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis킬러 면역글로불린 유사 수용체와 인간 백혈구 항원 리간드 사이의 전이성 상호작용은 강직성 척추염과 관련이 있습니다Research Article Published on 2020-08-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activating Activation allele Alter analysis ankylosing spondylitis Antigen Arthritis Autoimmune canonical carriage cause Cell cells class Cohort Combination combinations complement condition conducted contribute contributing to controls damage decrease develop disease dosage Endoplasmic reticulum epistatic interaction epistatic interactions ERAP1 Factor Genetic genetic factors genetic information genotype data Haplotype haplotypes healthy healthy control HLA HLA allele HLA alleles HLA ligand HLA ligands HLA-B human leukocyte antigen human population identify Immune cell immune cells immune system immune-cell Immune-mediated immune-mediated diseases Immunopathogenesis imputation individual Infectious disease inflammatory activity Inflammatory arthritis Inflammatory response inhibitory receptor Inhibitory Receptors instance instances Interaction investigated joint joints killer immunoglobulin-like receptors KIR KIR gene KIR genes KIR-HLA KIR3DL1 KIRs leukocyte Ligand ligands lymphocyte Lymphocytes malignant malignant cells natural killer Pathogenesis pathogenic variant pelvis proinflammatory provide receptor regulated repertoire Research risk shifting specificity spine spondylitis T-cells threshold tissue [DOI] 10.1371/journal.pgen.1008906 PMC 바로가기 [Article Type] Research Article
Pakistan Randomized and Observational Trial to Evaluate Coronavirus Treatment (PROTECT) of Hydroxychloroquine, Oseltamivir and Azithromycin to treat newly diagnosed patients with COVID-19 infection who have no comorbidities like diabetes mellitus: A structured summary of a study protocol for a randomized controlled trial당뇨병과 같은 동반 질환이 없는 새로 진단된 COVID-19 감염 환자를 치료하기 위한 Hydroxychloroquine, Oseltamivir 및 Azithromycin의 코로나바이러스 치료(PROTECT) 평가를 위한 파키스탄 무작위 및 관찰 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-08-082022-08-13 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 adaptive age allocation sequence approval authority Azithromycin baseline bioethics blinded Blinding board clinical Clinical improvement clinical status Cohort cohort study Combination combinations Committee Comorbidity comparator computer-generated Controlled trial coronavirus COVID-19 diabete diabetes Diabetes Mellitus diagnosed disease dissemination distress drug dyspneic Effectiveness eight element evaluate excluded expected Final flexibility Follow-up followed by Formal Gender groups Hospitalized Hydroxychloroquine hypertension Infection intervention group kidney Kidney failure lactating liver medical condition monotherapy multi-center multicenter nasal swab nucleic acid number objective observation open open label Ordinal Scale oseltamivir parameter participant patients patients with COVID-19 PCR positive pregnant Primary outcome Primary outcomes protocol public health qRT-PCR random randomization Randomized Randomized controlled trial randomized study recruited recruitment regimen Registered Registration reported respiratory distress Safety Sample size Self-isolation Seven seven-category ordinal scale Standard status Study protocol subject subsequent sulfate test negative tested three groups treat Treatment Trial twice a day Version virus website [DOI] 10.1186/s13063-020-04616-4 PMC 바로가기 [Article Type] Letter
Model‐informed drug repurposing: Viral kinetic modelling to prioritize rational drug combinations for COVID‐19Model-informed drug repurposing: COVID-19에 대한 합리적인 약물 조합을 우선시하는 바이러스 동역학 모델링Original Article Published on 2020-08-052022-08-31 Journal: British Journal of Clinical Pharmacology [Category] SARS, 신약개발, [키워드] addition approach AUC Cell cell cycle Combination combination therapy combinations COVID‐19 COVID‐19 patients COVID‐19 disease drug combination drugs early stage early stages effective Endpoint endpoints epithelial cell epithelial cells highlight host cell host cells Infection kinetic life cycle Metrics modelling outcome Patient performed phenotype reducing reduction repurposing Research Result SARS‐CoV‐2 shedding specific rate Stage therapeutic intervention Therapeutics Treatment Viral viral cell viral cell cycle viral life cycle Viral load viral replication viral shedding [DOI] 10.1111/bcp.14486 PMC 바로가기 [Article Type] Original Article
A Quantitative and Radiomics approach to monitoring ARDS in COVID-19 patients based on chest CT: a retrospective cohort studyResearch Paper Published on 2020-07-062022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress syndrome Analysis approach approach ARDS automatically baseline benefit Blood Chest Chest CT Chi-squared test Clinical use combinations Computed tomography COVID-19 COVID-19 patient dataset datasets decision curve analysis develop diagnosed with COVID-19 distress Effectiveness enrolled feasible feature Infection intubation Lungs male management median age Metrics MONITOR no significant difference noninvasive number of sample Patient patients Probability proportion protocol Quantitative Quantitative analysis Quantitative imaging Radiomics Randomly receiver operating characteristic Region retrospective cohort study ROC ROC Curve ROIs sensitivity specificity syndrome the patient threshold training dataset Ventilation was measured was used [DOI] 10.7150/ijms.48432 PMC 바로가기 [Article Type] Research Paper
Reducing mortality and morbidity in patients with severe COVID-19 disease by advancing ongoing trials of Mesenchymal Stromal (stem) Cell (MSC) therapy — Achieving global consensus and visibility for cellular host-directed therapiesEditorial Published on 2020-07-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 신약개발, 임상, [키워드] agency antiviral drug blueprint cause caused Cell cellular circulating clinical clinical trial Combination combinations Community Consensus COVID-19 COVID-19 mortality death death rate disease effective HDTs Host host-directed therapy immune Inflammatory response initiated long-term functional disability MERS-CoV morbidity Mortality mortality rates MSC MSC therapy MSCs novel coronavirus disease ongoing trial pandemic pathogen pathogenesis of SARS-CoV-2 Patient reducing mortality regimen registry reported Repurposed drug severe COVID-19 disease specific treatment STEM the WHO therapeutic interventions therapy Treatment treatment trial Trial turn underlie Vaccine WHO WHO ICTRP World Health Organization [DOI] 10.1016/j.ijid.2020.05.040 [Article Type] Editorial
Modeling the Spread of COVID-19 Infection Using a Multilayer PerceptronResearch Article Published on 2020-05-292022-10-31 Journal: Computational and Mathematical Methods in Medicine [Category] COVID-19, MERS, [키워드] Activation Algorithm ANN combinations COVID-19 Cross-validation dataset Deceased disease evaluated hidden Infectious disease information modeling Neuron Patient perceptron performed R 2 statistical while [DOI] 10.1155/2020/5714714 PMC 바로가기 [Article Type] Research Article
Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis임신 중 코로나바이러스 스펙트럼 감염(SARS, MERS, COVID-19) 결과: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2020-05-012022-09-11 Journal: American journal of obstetrics & gynecology MFM [Category] SARS, 변종, [키워드] 95% confidence interval accumulating acute respiratory syndrome Admission affected APGAR score asphyxia caution CINAHL clinical evidence Clinical sign Clinical signs Combination combinations confidence interval coronavirus Coronavirus 2019 Coronavirus infections cough counseling COVID-19 COVID-19 infection criteria database death defined Diagnosis disease distress during pregnancy Dyspnea eligibility eligible English language ENhance Evidence evidence of fetal fetal distress Fever growth Hospitalized inclusion criteria Infection infections intensive care membrane membranes MERS meta-analysis Meta-analysis Middle East Middle East respiratory syndrome miscarriage mode mother Neonatal neonatal asphyxia neonatal intensive care unit Newborn occurred outcome Perinatal death Pneumonia preeclampsia pregnancies Pregnancy pregnant women Premature prenatal Preterm birth proportion proportions reported respiratory rupture rupture of membranes searched Severe acute respiratory syndrome severe acute respiratory syndrome–coronavirus-2. Symptom syndrome systematic review These data Transmission variant vertical transmission with COVID-19 women [DOI] 10.1016/j.ajogmf.2020.100107 PMC 바로가기 [Article Type] Meta-Analysis
COVID-19 coronavirus: recommended personal protective equipment for the orthopaedic and trauma surgeonSports Traumatology Published on 2020-04-272022-10-31 Journal: Knee Surgery, Sports Traumatology, Arthroscopy [Category] COVID-19, SARS, [키워드] addition adopted aerosol-generating procedure Aerosols asked available data Blood body fluid combinations Contamination Corona country COVID-19 COVID-19 crisis COVID19 database effort Evidence Face shield Germany Google Scholar Guidance helmet help IMPROVE intubation Level Luxembourg Mask Masks operating theatre Personal protective equipment PHE physical contact PPE protection Public Health England recommendation recommendations reducing required Respirator Respirator masks Result risk Suits surgeon surgical Switzerland systematic review Transmission trauma virus particles was performed World Health Organization [DOI] 10.1007/s00167-020-06022-4 PMC 바로가기 [Article Type] Sports Traumatology
The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cellsResearch Article Published on 2017-03-292022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] A20 A549 activated acute respiratory distress adjust approach ARDS attenuate Cell cells cellular change characterized chromatin combinations Complete Concentration contribute coronavirus coronavirus coronavirus-infected cells correlated cytoplasm cytoplasmic de novo gene Degradation enhancer enhancer region Epigenetic event example expected expression expression level expression of gene Factor fine-tune Gene Expression Genes genes encoding Genome genome-wide investigation genomic region HCoV-229E HKU1 Host host cell host cell cytoplasm host response human coronavirus 229E humans identify IKK IKKβ IL-1 immunomodulatory factor immunomodulatory function infected cell infections Inflammatory Inflammatory cytokine involved IκBα Lung disease mechanism mechanisms MERS-CoV metabolic processes Modification molecular molecular basis motif NEMO NF-κB NF-κB signaling NL63 nuclear nuclear chromatin nucleus OC43 p65 pathogenic Pathogens pathology promote promoter Protein provide recruited recruitment regulatory region Replication required restrict RNA Polymerase II RNA virus SARS-CoV second shown Signaling subunit syndrome These cells TNFAIP3 transcribed Transcription transcription factor Transcriptome Treatment Trigger upper respiratory tract upregulated gene upregulation variety viral replication virus virus replication Virus-host interactions zoonotic coronavirus [DOI] 10.1371/journal.ppat.1006286 PMC 바로가기 [Article Type] Research Article