SARS-CoV-2 BA.1 variant is neutralized by vaccine booster-elicited serum, but evades most convalescent serum and therapeutic antibodiesResearch Article Published on 2022-04-052022-10-04 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome age antibodies antibody antibody cocktail Antibody therapeutics benefit booster booster vaccination comparable contagious convalescent serum coronavirus D614G variant description Effectiveness Emergency use evade evaluated immunization individual infecting maintain Medical countermeasures monoclonal antibodies mRNA mRNA vaccine Mutation neutralization neutralization activity neutralize neutralized not neutralize omicron polyclonal Protein pseudovirus raised responses retained SARS-CoV-2 serum serum sample Sex spike gene Spread tested the SARS-CoV-2 the United State therapeutic undetectable vaccinated individuals Vaccine variant variants [DOI] 10.1126/scitranslmed.abn8543 PMC 바로가기 [Article Type] Research Article
A case of primary COVID-19 pneumonia: plausible airborne transmission of SARS-CoV-2원발성 COVID-19 폐렴 사례: SARS-CoV-2의 그럴듯한 공기 전파Case Reports Published on 2022-04-042022-09-11 Journal: European Journal of Medical Research [Category] COVID19(2023년), SARS, 치료기술, [키워드] absence addition Admission aerosol Aerosols Airborne transmission airway alveolar anatomical Bioaerosols Bronchoalveolar lavage bronchoscopy Cholecystitis clearance contagious COVID-19 COVID-19 pneumonia CT scan detect Diagnosis diagnosis of COVID-19 different clinical manifestations Efficacy Evidence Ground glass opacity highlight increase in Infection limitation lower lobe lower respiratory system lung infiltrate nasal Patient Pneumonia positive qPCR right lower lobe RT-qPCR Saliva salivary SARS-CoV-2 Spread Swab Test tested Transmission transmission of SARS-CoV-2 upper airway upper respiratory upper respiratory tract Variability Viral load viral replication virus zone [DOI] 10.1186/s40001-022-00668-1 PMC 바로가기 [Article Type] Case Reports
Assessment of T-cell Reactivity to the SARS-CoV-2 Omicron Variant by Immunized Individuals면역화된 개인에 의한 SARS-CoV-2 오미크론 변이체에 대한 T 세포 반응성 평가Article Published on 2022-04-012022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 변종, [키워드] age assessment blood sample Blood samples Care CD4+ cell CD4+ cells CD4+ T cell CD4+ T cells CD8+ T cells Cell cellular component cellular immunity cohort study conducted contagious decrease determine enrolled foundation Frequency full-length protein group Health Health care highlight Hospitalization immune immune protection immune system Immunity immunized individual Infection Italy Lymphocytes median mutated Mutation Neutralizing new SARS-CoV-2 no significant differences omicron Omicron variant outcome participant peptide peptides reactive reactivity reduced reduction Region regions Rome SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera severe disease significant difference significantly Spike protein Stimulation T cells T-cell T-cell immunity tested the SARS-CoV-2 the spike protein vaccination variant variant of SARS-CoV-2 Volunteer volunteers women [DOI] 10.1001/jamanetworkopen.2022.10871 PMC 바로가기 [Article Type] Article
Italian national policies in response to the COVID-19 pandemic: The case of the Friuli-Venezia-Giulia and Umbria RegionsCOVID-19 전염병에 대응하는 이탈리아 국가 정책: Friuli-Venezia-Giulia 및 Umbria 지역 사례Article Published on 2022-04-012022-09-11 Journal: Health policy (Amsterdam, Netherlands) [Category] 변종, [키워드] Analysis contagious COVID-19 COVID-19 pandemic Effect European country Government Italian Italian government Italian municipalities Italy lockdown Mild National outbreak pandemic Region Relaxation Relaxation policies second wave Spread variant virus zone Zone-based policies. [DOI] 10.1016/j.healthpol.2022.02.004 PMC 바로가기 [Article Type] Article
Immunogenicity of a recombinant VSV-Vectored SARS-CoV vaccine induced robust immunity in rhesus monkeys after single-dose immunization재조합 VSV-Vectored SARS-CoV 백신의 면역원성은 단일 용량 면역 후 붉은털 원숭이에서 강력한 면역을 유도했습니다Article Published on 2022-04-012022-09-12 Journal: Virologica Sinica [Category] SARS, 진단, [키워드] accumulate acute respiratory syndrome animal models can be used caused chimeric China contagious coronavirus coronavirus disease COVID-19 death disease dose effective G protein glycoprotein Guangdong heterogeneous human population humans Immunity immunization immunogenic antigen immunogenicity indicate induce Infection maintain mice Neutralizing antibodies neutralizing antibody New coronavirus non-human primate novel coronavirus disease outbreak Protein rapid response replaced reported Rhesus monkey robust S protein Safe SARS Coronavirus SARS-CoV SARS-CoV S SARS-CoV vaccine severe acute respiratory syndrome coronavirus (SARS-CoV) spike T cell response TCID Trial Vaccine vaccine candidate Vaccine development vesicular stomatitis vesicular stomatitis virus vesicular stomatitis virus (VSV) virus VSV zoonotic disease [DOI] 10.1016/j.virs.2022.01.002 PMC 바로가기 [Article Type] Article
Comparative structural analyses of selected spike protein-RBD mutations in SARS-CoV-2 lineagesSARS-CoV-2 계통에서 선택된 스파이크 단백질-RBD 돌연변이의 비교 구조 분석Article Published on 2022-04-012022-09-11 Journal: Immunologic research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting Analysis B.1.1.7 B.1.351 B.1.617 B.1.617.2 Brazil claimed Comparative contagious coronavirus country delta variant described domain examined implication India initial Lineage lineages mutant strain Mutation mutations pathogenic Point mutation RBD SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 lineages selected severe acute respiratory syndrome Coronavirus severity of COVID-19 South Africa spike Spike protein Structural biochemistry Structure the spike protein variant variants Variants, Virus structure. virulent Virulent mutant virus [DOI] 10.1007/s12026-021-09250-z PMC 바로가기 [Article Type] Article
Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals세로 방향 면역 프로파일링은 COVID-19 회복기 개인의 장기 체액성 면역을 매개하는 지배적인 에피토프를 나타냅니다Article Published on 2022-04-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antibody Antibody Response caused circulating variants concerning contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19-convalescent individual COVID-19-convalescent individuals cytokine cytokine production diagnostic disease onset dissect dominant dominant epitope early stage early stages endemic human coronavirus endemic human coronaviruses epitope Epitopes fatality feature global pandemic highly pathogenic humoral humoral immune responses Humoral immunity immune immune profiling immune response immune responses Immunity individual induce Kinetics long-term immune response long-term immune responses Longevity longitudinal longitudinal analysis mapped moderate moderate symptoms N-terminal domain Neutralizing antibodies neutralizing antibody ORF1ab path patients peptide peptide microarray performed Protein Proteins proteome proteome-wide peptide microarray. reactive respiratory responsible reveal S1 subunit S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein sequence homology sequence identity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specific antibodies Spike protein sustained symptoms of COVID-19 the early SARS-CoV-2 the S1 subunit the SARS-CoV-2 Vaccine design Wuhan-Hu-1 [DOI] 10.1016/j.jaci.2022.01.005 PMC 바로가기 [Article Type] Article
Evaluation of science advice during the COVID-19 pandemic in Sweden Research Published on 2022-03-222022-10-05 Journal: Humanities & Social Sciences Communications [Category] 치료법, [키워드] acting Administered approach asymptomatic individual contagious Control COVID-19 COVID-19 pandemic Culture death rate evaluate Evidence extreme Face mask independent International Karolinska Institute lack media methodology National Norway occurred over oxygen pandemic pandemic of COVID-19 Pandemics Prevent PROTECT Public recommendation responsible resulting SARS-CoV-2 transmission Scientific community Swedish [DOI] 10.1057/s41599-022-01097-5 [Article Type] Research
Matrix-Assisted Laser Desorption and Ionization Time-of-Flight Mass Spectrometry Analysis for the Direct Detection of SARS-CoV-2 in Nasopharyngeal Swabs비인두 면봉에서 SARS-CoV-2의 직접 검출을 위한 매트릭스 보조 레이저 탈착 및 이온화 비행 시간 질량 분석 분석Article Published on 2022-03-152022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid anion exchange resin biological molecule biological molecules cartridge Chain Reaction Combination complex contagious coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patients detect detection Diagnostic method digested Direct Evidence flight identify in some inoculated ionization labor-intensive Laser limit of detection mass mass spectrometry Nasopharyngeal swab nasopharyngeal swab specimen Nasopharyngeal swab specimens nasopharyngeal swabs nucleocapsid patients PCR peptide peptides polymerase chain polymerase chain reaction positive result purification purified Real-Time Reverse Transcription Polymerase Chain Reaction reverse transcription reverse transcription polymerase chain reaction SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral particle SARS-CoV-2 viral particles SARS-CoV-2-specific peptide SARS-CoV-2-specific peptides selected separated Seven severe acute respiratory syndrome Coronavirus specimen specimens Spectrometry Swab the SARS-CoV-2 trypsin Viral load was performed [DOI] 10.1021/acs.analchem.1c04328 PMC 바로가기 [Article Type] Article
A spatiotemporally resolved infection risk model for airborne transmission of COVID-19 variants in indoor spaces실내 공간에서 COVID-19 변종의 공중 전파에 대한 시공간적으로 해결된 감염 위험 모델Article Published on 2022-03-152022-09-11 Journal: The Science of the total environment [Category] SARS, 변종, [키워드] Airborne infection airflow application applied breathing CFD classic Clinical data Combination Computational fluid dynamics contagious coughing COVID-19 COVID-19 patient COVID-19 patients COVID-19 transmission Delta delta variant distribution effective estimation exposure to Factor filtration flexibility healthcare heterogeneous hospital ward human cells Impact infecting Infection infection risk location movement novel omicron pathogen Pathogens PPE Predictive quantified Quantitative resolved risk SARS-CoV-2 SARS-CoV-2 variant sneezing spatiotemporal Spatiotemporal infection risk Stage Strains susceptible individuals Transmission Transport vaccination variant Ventilation viral shedding virus virus variant Wells-Riley model [DOI] 10.1016/j.scitotenv.2021.152592 PMC 바로가기 [Article Type] Article