No clinical benefit of high dose corticosteroid administration in patients with COVID-19: A preliminary report of a randomized clinical trialRandomized Controlled Trial Published on 2021-04-152022-10-05 Journal: European journal of pharmacology [Category] 임상, [키워드] acute respiratory distress Administered administration ARDS assigned changes in clinical benefit Clinical effect Clinical improvement Computed tomography control group control groups coronavirus disease Corticosteroid Corticosteroids COVID-19 death rate Dexamethasone died discharged dose evaluate follow-up period had no High dose hospital Hospital stay Invasive mechanical ventilation median Mild moderate Noninvasive ventilation outcomes Patient preliminary report radiological randomized clinical trial Randomly required SARS-CoV-2 significant difference syndrome the median were assessed [DOI] 10.1016/j.ejphar.2021.173947 PMC 바로가기 [Article Type] Randomized Controlled Trial
Assessment of Studies Evaluating Spinal Manipulative Therapy and Infectious Disease and Immune System Outcomes A Systematic Review척추 수기 치료 및 감염성 질환 및 면역 체계 결과를 평가하는 연구의 평가 체계적인 검토Research Published on 2021-04-132022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 바이오마커, 임상, [키워드] article assessment association Asymptomatic back pain Biomarker Biomarkers changes in chiropractic clinical evidence Clinical studies clinical study clinical trial clinical trials Cohort studies cohort study conducted contributed control groups Controlled controlled trials COVID-19 pandemic effective Effectiveness Efficacy Endocrine Evaluating Evidence experiment finding Health Organization Health Organization) identify immune immune function immune system immunological Importance IMPROVE improvement Improvements inception index indicated Infectious disease Infectious diseases infodemic information investigated Laboratory lack limitation literature low back pain lymphocyte manipulative marker Nursing objective outcome outcomes participant Participants Patient physiological Point Preliminary data Premature RCT referred to Relevance review screened selected short term spinal Spread Support synthesis System systematic review therapy venipuncture World Health Organization [DOI] 10.1001/jamanetworkopen.2021.5493 PMC 바로가기 [Article Type] Research
Methylprednisolone or dexamethasone, which one is superior corticosteroid in the treatment of hospitalized COVID-19 patients: a triple-blinded randomized controlled trial입원한 COVID-19 환자의 치료에서 우수한 코르티코스테로이드인 Methylprednisolone 또는 dexamethasone: 삼중 맹검 무작위 대조 시험Research Article Published on 2021-04-102022-07-28 Journal: BMC Infectious Diseases [Category] 임상, [키워드] Admission clinical status conducted control group control groups coronavirus disease Coronavirus disease 2019 Corticosteroid COVID-19 COVID-19 patients death demonstrated Dexamethasone dose Effectiveness enrolled group Hospital stay Hospitalized hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxic Intervention intervention group Iran measure Methylprednisolone no significant difference no significant differences on admission Ordinal Scale outbreak Patient Randomized controlled trial Randomly receive Registered remained Result significant difference significantly significantly lower Treatment treatment of COVID-19 Trial Trial registration two group two groups uninfected Vaccine ventilator were assessed WHO ordinal scale PMC 바로가기 [Article Type] Research Article
The course of subjective and objective chemosensory dysfunction in hospitalized patients with COVID-19: a 6-month follow-upRhinology Published on 2021-04-102022-10-31 Journal: European archives of oto-rhino-laryngology : offic [Category] COVID-19, MERS, SARS, [키워드] analogue Anosmia chemosensory Chemosensory dysfunction Cohort control groups coronavirus Course COVID-19 diagnosed dysfunction Effect elevated examined FIVE Follow-up hospitalized patient Hyposmia identification impairment Infection infection with SARS-CoV-2 initial negative control no difference olfactory dysfunction Patient patients performed positive patients Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2-positive patient scale significantly Smell smell training strip suffered Taste Test Visual [DOI] 10.1007/s00405-021-06796-4 PMC 바로가기 [Article Type] Rhinology
Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients중증 코로나19 환자 치료에 이버멕틴 추가의 유효성 및 안전성 평가Clinical Trial Published on 2021-04-042022-07-29 Journal: BMC Infectious Diseases [Category] 임상, 치료제, [키워드] added affecting Alter average Azithromycin azithromycin- blood lymphocyte count C-reactive protein can be used cause changes in Clinical improvement clinical recovery clinical response control group control groups COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 pneumonia COVID19 pneumonia CRP D-dimer level D-dimer levels decrease drug Effect effective Effectiveness enteral use evaluate evaluated Favipiravir ferritin FiO2 follow-up period gene mutation gene mutations genetic test genetic tests groups Hydroxychloroquine increase in investigated Ivermectin ivermectin metabolism ivermectin treatment laboratory parameter Laboratory parameters lymphocyte material metabolism Mortality mortality rate mortality rates Mutation oxygen oxygen saturation PaO2 partial pressure Partial pressure of oxygen Patient patients performing sequence analysis peripheral capillary phase 3 study Pneumonia prognostic protocol protocols randomization Randomized reduction in reference treatment Result Sanger method SARS CoV-2 SARS-CoV2 Sequence analysis serum serum C-reactive protein severe COVID-19 severe COVID-19 patient Severe COVID-19 pneumonia single-blind solution SpO2 study group supplementary material the study group toxic effect toxic effects Treatment two groups were excluded were given while PMC 바로가기 [Article Type] Clinical Trial
Efficacy of the combination of modern medicine and traditional Chinese medicine in pulmonary fibrosis arising as a sequelae in convalescent COVID-19 patients: a randomized multicenter trial회복기 COVID-19 환자의 후유증으로 발생하는 폐 섬유증에 대한 현대 의학 및 한약 조합의 효능: 무작위 다기관 시험Clinical Trial Published on 2021-03-182022-09-10 Journal: Infectious Diseases of Poverty [Category] SARS, 임상, 치료제, [키워드] (pirfenidone acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Administered affected affecting age arising candidate caused Chinese Chinese Clinical Trial Registry clinical clinical manifestation clinical manifestations Combination conducted control group control groups convalescent coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 cases Critical critical condition deficiency determine Effectiveness eligible expiratory expiratory vital capacity feasible fibrosis IMPROVE Inclusion indicated infected patient infected patients lead life Lung function manifestation modern medicine mortalities Mortality multicenter Multicenter trial parallel-group participant Patient patients Pirfenidone Placebo Prospective clinical trial Prospective trial Psychology pulmonary pulmonary fibrosis Quality of life Randomized receive recorded reducing Registered registry reported respiratory SARS-CoV-2 SARS-COV-2 infection SASR-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly syndrome TCM the disease Traditional Chinese medicine Treatment treatment group Trial registration two groups vital capacity Well-being [DOI] 10.1186/s40249-021-00813-8 PMC 바로가기 [Article Type] Clinical Trial
Chinese Herbal Medicine Used With or Without Conventional Western Therapy for COVID-19: An Evidence Review of Clinical StudiesPharmacology Published on 2021-02-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 95% CI 95% confidence interval addition adverse events Analysis analyzed Characteristics Chest CT Chinese Chinese herbal medicine CHM clinical clinical study Comparator group control group control groups Controlled trial Conventional Coronavirus disease 2019 cough COVID-19 current duration of fever evaluated Evidence fatigue FIVE Herbal injection intervention group manifestation mean difference Medicine Methodological quality Negative conversion rate no statistical difference non-randomized novel coronavirus pneumonia nucleic acid test Randomized controlled trial RCT RCTs receiving reducing Retrospective study review risk risk of bia SARS-CoV-2 statistical difference tested therapeutic effect therapy therapy for COVID-19 Traditional Chinese medicine Treatment [DOI] 10.3389/fphar.2020.583450 PMC 바로가기 [Article Type] Pharmacology
Is there a link between pre-existing antibodies acquired due to childhood vaccinations or past infections and COVID-19? A case control studyImmunology Published on 2021-02-092022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] affected antibody Antibody titer Antibody titers antigens association AST Asymptomatic biochemical Bordetella pertussis case control study case-control study childhood children circulating circulating antibodies control group control groups Covid patients COVID-19 COVID-19 severity cross-protection D-dimer disease disease severity Evidence ferritin healthy controls healthy volunteers Hypothesis identify immune memory Infection infection markers less Level memory Mild pandemic patients with COVID-19 pneumococcus procalcitonin Protective Result rubella severity Severity of disease significantly increased significantly lower Support the disease vaccination Vaccinations Vaccine [DOI] 10.7717/peerj.10910 PMC 바로가기 [Article Type] Immunology
Renin-Angiotensin-Aldosterone System Inhibitors and COVID-19: A Meta-Analysis and Systematic ReviewCardiology Published on 2021-02-042022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% CI ACEi/ARB age AHA angiotensin-converting enzyme inhibitor ARB average benefit C-reactive protein (CRP Cardiology cardiovascular diseases cardiovascular prevention Cochrane Library college control group control groups coronavirus disease COVID 19 COVID-19 COVID-19 severity CRP D-dimer decrease disease severity female group heart hypertension in the global context Increased increased mortality Infection Inflammation Inflammatory marker microcirculation and inflammation Mortality no significant difference Odds ratio outcome patients patients with COVID-19 Protective protective effect RAS receptor reported Result review Sample size searched severity severity of COVID-19 signaling pathway statistically significant statistically significant difference study population Support System virulence were assessed with COVID-19 worsened [DOI] 10.7759/cureus.13124 PMC 바로가기 [Article Type] Cardiology
Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled TrialCOVID-19 환자에서 Baloxavir Marboxil 및 Favipiravir의 임상 결과 및 혈장 농도: 탐색적 무작위 대조 시험Randomized Controlled Trial Published on 2021-02-012022-09-11 Journal: European journal of pharmaceutical sciences : offi [Category] SARS, 임상, 치료제, [키워드] addition antiviral activities antiviral activity antiviral drug antiviral drugs Arbidol Arm assigned baloxavir baloxavir acid baloxavir marboxil benefit Blood Chinese Chinese Clinical Trial Registry clinical clinical benefit clinical benefits Clinical improvement Clinical outcome clinical outcomes comparable Concentration conducted control group control groups Controlled COVID-19 COVID-19 patients Day dosage drug enrolled evaluate evaluated exploratory Favipiravir half-maximal effective concentration Hospitalized in vitro lack limitation Lopinavir medians Patient patients with COVID-19 pharmacokinetics plasma concentration plasma concentrations Primary outcome randomization Randomized reason for reduction Registered registry SARS-CoV-2 standard treatment subject symptom onset the half-maximal effective concentration (EC(50)). the median Treatment Trial Viral Virological [DOI] 10.1016/j.ejps.2020.105631 PMC 바로가기 [Article Type] Randomized Controlled Trial