Mismatch between circulating cytokines and spontaneous cytokine production by leukocytes in hyperinflammatory COVID-19과염증 COVID-19에서 백혈구에 의한 순환 사이토카인과 자발적 사이토카인 생산 간의 불일치Clinical Trial Published on 2021-01-012022-09-12 Journal: Journal of leukocyte biology [Category] MERS, 임상, 진단, [키워드] activated Activation analyzed blockade cellular circulating cytokine circulating leukocyte contribute Control controls COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine production Cytokine storm cytokine storm, monocytes. Cytokines disease example flow cytometry healthy control healthy controls hyperinflammation Hyperinflammatory IL-1β IL-6 IL-8 immunoassay investigated leukocyte LPS lymphocyte mismatch monocyte Monocytes Patient patients with COVID-19 PBMC produced recruited Sepsis sepsis patient sepsis patients severe COVID-19 Support surface marker TNF Treatment university was used were measured worldwide pandemic [DOI] 10.1002/JLB.5COVBCR0720-310RR PMC 바로가기 [Article Type] Clinical Trial
Recombinant SARS-CoV-2 Spike Protein Mediates Glycolytic and Inflammatory Activation in Human MonocytesAbstracts Published on 2020-12-162022-10-30 Journal: Innovation in Aging [Category] COVID-19, [키워드] ACE2 receptor activate Activation acute respiratory syndrome cause caused cell lysate Contamination coronavirus disease Coronavirus-2 COVID-19 cytokine production Cytokine storm Donor Efficacy ELISA endotoxin Evidence Extracellular facilitate Glycolysis healthy human monocyte human monocytes Immune cell increase in Inflammation Inflammatory Inflammatory response Interaction interleukin-6 investigated marrow-derived macrophage metabolic monocyte mouse processed Protein protein expression qPCR Rapamycin recombinant SARS-CoV-2 SARS-CoV-2 spike protein Seahorse spike stimulated subunit the spike protein treating COVID-19 upregulation [DOI] 10.1093/geroni/igaa057.3493 PMC 바로가기 [Article Type] Abstracts
Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical TrialRandomized Controlled Trial Published on 2020-12-082022-10-05 Journal: JAMA [Category] 임상, [키워드] absolute difference acute respiratory syndrome adult outpatient adverse events age assigned clinical Clinical deterioration Clinical efficacy clinical trial coronavirus Coronavirus disease 2019 COVID-19 criteria cytokine production decrease defined Deterioration determine enrolled excessive immune response Final fluvoxamine Follow-up greater Hospitalization Infection less likelihood mild COVID-19 illness occurred outcome outcome measures Outpatient oxygen saturation participant Patient patients treated Placebo Pneumonia Prevent Primary outcome randomization Randomized randomized trial Randomly receive receptor regulate Serious Adverse Event Severity of disease Shortness of breath small sample size supplemental oxygen survival symptom onset symptomatic the placebo group Trial with COVID-19 women [DOI] 10.1001/jama.2020.22760 PMC 바로가기 [Article Type] Randomized Controlled Trial
Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profilesSARS-CoV-2 및 ORF8이 결여된 382-nt 결실 분리주에 의한 인간 비강 상피 세포의 감염은 유사한 바이러스 동역학 및 숙주 전사 프로필을 나타냅니다Research Article Published on 2020-12-072022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] absence airway airway epithelial cells anti-viral gene up-regulation anti-viral signaling pathway anti-viral signaling pathways apical side basolateral secretion causative agent cell type cell types comparable conserved expression coronavirus disease Coronavirus disease 2019 CoV COVID-19 COVID-19 patients CXCL10 CXCL10 production cytokine cytokine production Cytokines differentiated NEC differentiated NECs distinct gene subset distinct gene subsets Duration of infection early response elevated elicited epithelial epithelial cell epithelial cells examined genomes global healthcare greater magnitude H3N2 healthy nasal-tissue highlight Host host gene expression Host immune response Host transcriptional response host-response hours post-infection hpi IL-6 Immune cell infiltration immune cells immune response impair in vitro In-vitro infancy infected cells infected NEC infected NECs Infection Infection of NEC Infection of NECs Infection with Δ382 infiltrating immune cell infiltrating immune cells Inflammatory response Influenza influenza strain late time-point late time-points less modulating Nasal Epithelial cells NECs Novel coronavirus novel coronavirus SARS-CoV-2 ORF8 other SARS-CoV-2 genes Pathogenesis patient sera patients plasticity post-infection time-point pro-inflammatory cytokine pro-inflammatory cytokines released reported reveal SARS-CoV-2 SARS-CoV-2 and Δ382 infection SARS-CoV-2 genes SARS-COV-2 infection Screening severe disease significantly similar replication kinetics similarities similarity Singapore stem cell stem cells subsequent cytokine production temporal up-regulation therapeutic node TNFα transcriptional transcriptional profile Transcriptome transcriptome analysis transcripts transcripts mapping understanding Viral viral clearance viral kinetics virus particle virus particles wild-type and Δ382 wild-type SARS-CoV-2 Δ382 Δ382 infected cell Δ382 infected cells Δ382 infection [DOI] 10.1371/journal.ppat.1009130 PMC 바로가기 [Article Type] Research Article
Taming the cytokine storm: repurposing montelukast for the attenuation and prophylaxis of severe COVID-19 symptoms사이토카인 폭풍 길들이기: 심각한 COVID-19 증상의 약화 및 예방을 위한 몬테루카스트 용도 변경Article Published on 2020-12-012022-09-11 Journal: Drug discovery today [Category] 신약개발, [키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approved Asthma attenuation characterized clinical complication Clinical outcome clinical outcomes coronavirus COVID-19 cytokine cytokine production cytokine profile Cytokine storm decrease Hyperinflammatory immune response infections Inflammation involved mediators modulate Montelukast NF-κB NF-κB activation nuclear Patient proinflammatory mediator proinflammatory mediators Prophylaxis protein complex reduction in respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 symptom suppress symptom severity Viral viral infections [DOI] 10.1016/j.drudis.2020.09.013 PMC 바로가기 [Article Type] Article
Comparative Transcriptome Analysis Reveals the Intensive Early Stage Responses of Host Cells to SARS-CoV-2 InfectionMicrobiology Published on 2020-11-252022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] accompanied acute respiratory syndrome Analysis antiviral response Bioinformatics analysis Calu-3 cell caused Comparative coronavirus coronavirus disease COVID-19 cytokine cytokine production disease pathogenesis Efficiency Evidence Gene Expression growth highly pathogenic host antiviral response host antiviral responses host cell host cells host early response host gene host genes host response host transcriptome implicated Infection Intensive Interaction late stage mechanism MERS-CoV Middle East molecular outbreak pathogenicity performed respiratory syndrome coronavirus response SARS-CoV SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Sequencing Stage the SARS-CoV-2 time-series transcriptome TMPRSS2 triggered up-regulated virus virus genome while widespread [DOI] 10.3389/fmicb.2020.593857 PMC 바로가기 [Article Type] Microbiology
CD71 + Erythroid Cells in Human Neonates Exhibit Immunosuppressive Properties and Compromise Immune Response Against Systemic Infection in Neonatal MiceImmunology Published on 2020-11-242022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] abrogated activated Against age apocynin appear Asymptomatic Bacteria Blood Bone marrow Brain CD14 CD45 CD71+ erythroid cells compromise control group COVID-19 COVID-19 infection cytokine production Diseases erythroid explain expressing Frequency highlight Human Immune cell immune system Immunosuppression immunosuppressive in vitro Infant Infants Infection Listeria monocytogene liver mechanism mice Mild monocyte Neonatal neonatal infections Neonate Newborn Newborns Older Peripheral blood physiological potential mechanism precursor property proportion reactive oxygen specy reduction in regulated response ROS ROS production significantly higher spleen suppressed survival rate susceptibility susceptible systemic T cells these cell [DOI] 10.3389/fimmu.2020.597433 PMC 바로가기 [Article Type] Immunology
The frequency of combined IFITM3 haplotype involving the reference alleles of both rs12252 and rs34481144 is in line with COVID-19 standardized mortality ratio of ethnic groups in Englandrs12252 및 rs34481144의 참조 대립유전자를 포함하는 결합된 IFITM3 일배체형의 빈도는 영국의 인종 그룹의 COVID-19 표준화된 사망률과 일치합니다Computational Biology Published on 2020-11-122022-08-13 Journal: PeerJ [Category] 유전자 메커니즘, [키워드] 1000 Genomes Project allele allele frequency alleles Analysis Asian association Bame black cellular Chinese Cohort collected Combination contribute correlation COVID-19 COVID-19 patient COVID-19 severity cytokine cytokine production Dengue Ebola England ethnic group Ethnic groups explain focus Frequency Genetic Haplotype HIV IFITM3 immune effector protein implicated implication Implications Influenza Invasion Latino mechanism Mortality mortality risk outcome past polymorphism Population protein 3 reference allele Regulation reported restriction rs12252 rs34481144 SARS-CoV-2 SARS-CoV-2 pandemic severity SNP Socioeconomic factor Socioeconomic Factors standardized mortality ratio Standardized Mortality Ratios subgroup subgroups suggested the disease transmembrane protein USA vaccination efficacy variant Viral viral replication viruses while White people with COVID-19 [DOI] 10.7717/peerj.10402 PMC 바로가기 [Article Type] Computational Biology
Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils’ but Impaired Monocytes’ and Dendritic Cells’ ResponsivenessArticle Published on 2020-09-292022-10-31 Journal: Cells [Category] COVID-19, [키워드] caused COVID-19 cytokine cytokine production Cytokine storm degranulation demonstrated dendritic cell dendritic cells disease driver feature forms functional Health highlight hyperinflammation IFN alpha immature Impaired innate immune Innate immunity Interaction interferon involved low expression maturation mechanisms monocyte Monocytes NETosis neutrophil Neutrophils pandemic disease PD-L1 phenotype profile reduce Research responses responsiveness SARS-CoV-2 SARS-CoV-2 virus severity of COVID-19 signature therapeutic targeting with COVID-19 [DOI] 10.3390/cells9102206 PMC 바로가기 [Article Type] Article
Perspective: The Potential Effects of Naringenin in COVID-19Immunology Published on 2020-09-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 acute respiratory syndrome Anti-inflammatory anti-inflammatory property Antiviral caused Chronic illness compounds Coronavirus disease 2019 COVID-19 COVID-19 case cytokine production death develop diabetes Effect higher risk hypertension include investigated multiple organ failure naringenin obesity pandemic Perspective Potential reducing respiratory risk factor SARS-CoV-2 SARS-COV-2 infection Sepsis specific treatment subject TNF Vaccine viral replication World Health Organization [DOI] 10.3389/fimmu.2020.570919 PMC 바로가기 [Article Type] Immunology