Comparing efficacy and safety of tocilizumab and methylprednisolone in the treatment of patients with severe COVID-19중증 COVID-19 환자 치료에서 토실리주맙과 메틸프레드니솔론의 효능 및 안전성 비교Article Published on 2022-06-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] 28-day mortality 95% CI adverse event adverse events alternative caused clinical clinical response comparable COVID Cox regression analysis CRP Dexamethasone dose doses duration of hospitalization Efficacy and safety faster group groups hospitalized patient hospitalized patients ICU admission improvement intravenous methylprednisolone Methylprednisolone not significantly different occurred Other outcome oxygen oxygen saturation Patient Primary outcome problem prospective cohort study secondary Secondary outcomes severe COVID-19 Sleep disturbance Sleep disturbances statistically significant Tocilizumab Treatment were recorded [DOI] 10.1016/j.intimp.2022.108689 PMC 바로가기 [Article Type] Article
Dexamethasone as risk-factor for ICU-acquired respiratory tract infections in severe COVID-19Multicenter Study Published on 2022-06-012023-07-08 Journal: Journal of critical care [Category] COVID19(2023년), [키워드] COVID-19 Critical care Dexamethasone Pneumonia severe COVID-19 [DOI] 10.1016/j.jcrc.2022.154014 PMC 바로가기 [Article Type] Multicenter Study
Comparing the efficacy of tocilizumab with corticosteroid therapy in treating COVID-19 patients: a systematic review and meta-analysisCOVID-19 환자 치료에서 토실리주맙과 코르티코스테로이드 요법의 효능 비교: 체계적인 검토 및 메타 분석Review Published on 2022-06-012022-09-12 Journal: Daru : journal of Faculty of Pharmacy, Tehran Univ [Category] COVID19(2023년), SARS, 진단, [키워드] 95%CI baseline characteristics Case-control case-control studies case-control study Combination contributed Corticosteroid corticosteroid therapy COVID-19 database determinant Dexamethasone did not reduce dose regimen drug Drug efficacy Efficacy Factor High dose identify IMPROVE mechanical ventilation Meta-analysis Methylprednisolone Mortality outcome Patient patients pulse Randomized Randomized controlled trial randomized trials RCT RCTs reduce reducing mortality reduction searched severe COVID-19 patients shown significantly systematic review therapeutic therapy Tocilizumab treating COVID-19 was performed [DOI] 10.1007/s40199-021-00430-8 PMC 바로가기 [Article Type] Review
Discovery of new drug indications for COVID-19: A drug repurposing approachCOVID-19에 대한 신약 적응증의 발견: 약물 용도 변경 접근Article Published on 2022-05-242022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] addition adopted Analysis anti-SARS-CoV-2 antiviral activity approach approved Baricitinib benefit binding energy calculated candidate drugs carried caused Cluster cluster analysis Clustering Combination Compound coronavirus demonstrated Dexamethasone docking result docking results docking study Doxorubicin drug drugs effective embedding Final generate generic drugs Health help in-silico In-vitro indication Interaction likelihood measure optics Ordering outbreak outlier performed Point PubChem public health Remdesivir Research Safety measures SARS-CoV-2 similarity stochastic Structure suggested Symptom Target genes therapy unique utility [DOI] 10.1371/journal.pone.0267095 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severityArticle Published on 2022-05-192022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료법, 치료제, [키워드] Adaptive immunity Affect Blood cellular COVID-19 COVID-19 patients cytokine response Dexamethasone disease severity domain Hospital stay hospitalized COVID-19 patients humoral Humoral response IFN-α2 IgA IgG IgM IgM and IgG IL-12p70 immune immune component immune parameter immune response immunopathology infection with SARS-CoV-2 Inflammation mechanism neutralization Neutrophils not affect Peripheral blood plasma Prognosis respiratory respiratory sample Respiratory samples respiratory specimen respiratory specimens respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralization activity Seroconversion sputum subset therapy Treatment viral infection [DOI] 10.1038/s41467-022-30088-y PMC 바로가기 [Article Type] Article
Effects of Drugs Formerly Suggested for COVID-19 Repurposing on Pannexin1 Channels이전에 COVID-19 용도 변경을 위해 제안된 약물이 Pannexin1 채널에 미치는 영향Article Published on 2022-05-182022-09-11 Journal: International Journal of Molecular Sciences [Category] 신약개발, 유전자 메커니즘, [키워드] Alter Analysis Anti-inflammatory Anti-inflammatory drugs Antiviral antiviral and anti-inflammatory drugs Azithromycin candidate Chain Reaction channel Chloroquine clinical trial clinical trials Combination COVID-19 COVID-19 patients Dexamethasone Diseases drug drug candidate drug target Effect effort extracellular ATP Favipiravir functional Hydroxychloroquine immune response Immunoblot analysis Inflammation inhibit inhibitor Lopinavir mechanism mRNA expression mRNA levels outcome pandemic pannexin1. Pathogenesis pathogenesis of COVID-19 polymerase chain polymerase chain reaction Protein Quantitative Remdesivir repurposing ribavirin Ritonavir selected tested Treatment viral infections were used without affecting [DOI] 10.3390/ijms23105664 PMC 바로가기 [Article Type] Article
Computational study on the affinity of potential drugs to SARS-CoV-2 main proteaseArticle Published on 2022-05-182023-07-09 Journal: Journal of physics. Condensed matter : an Institute of Physics journal [Category] COVID19(2023년), [키워드] betamethasone Chloroquine Dexamethasone Hydroxychloroquine molecular docking SARS-CoV-2 main protease [DOI] 10.1088/1361-648X/ac6c6c
Agreement of treatment effects from observational studies and randomized controlled trials evaluating hydroxychloroquine, lopinavir-ritonavir, or dexamethasone for covid-19: meta-epidemiological study코로나19에 대한 히드록시클로로퀸, 로피나비르-리토나비르 또는 덱사메타손을 평가하는 관찰 연구 및 무작위 대조 시험의 치료 효과 일치: 메타 역학 연구Article Published on 2022-05-102022-09-11 Journal: The BMJ [Category] meta-analysis, 임상, [키워드] age agreement Analysis calculated Clinical data collected Comparisons complement conducted controlled trials COVID-19 treatment criteria data extraction database demographical and clinical data demographics Dexamethasone disease severity distribution Efficacy Epidemiological study evaluated Evidence Hydroxychloroquine identify independent Lopinavir Lopinavir-ritonavir Matched means Medicine meta-analysed meta-analyses Meta-analysis Network meta-analysis nine not significant observational studies observational study outcome outcomes overlapping Placebo PLOS proportion Randomized controlled trial RCT RCTs reported Ritonavir Safety sequential analysis Seven Sex significantly synthesis systematic review therapeutic intervention therapeutic interventions Treatment treatment effect treatment effects trial sequential analysis [DOI] 10.1136/bmj-2021-069400 PMC 바로가기 [Article Type] Article
Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery SystemsReview Published on 2022-05-092022-10-04 Journal: ACS Biomaterials Science & Engineering [Category] 신약개발, [키워드] Administered allergies approach Autoimmune diseases Cancer Cell COVID-19 delivery Dexamethasone disease Diseases disorders drug drug delivery Drug repurposing Effect elicit healthy hyperglycemia hypertension inhibiting insight nanomaterials ocular organ phosphate polymers provide Research Side effects System tissue tissue engineering treat variety [DOI] 10.1021/acsbiomaterials.2c00026 PMC 바로가기 [Article Type] Review
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomicsCOVID-19 햄스터 모델에서 덱사메타손 및 항체 치료의 주요 이점, 단일 세포 전사체로 밝혀짐Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed Anti-inflammatory anti-inflammatory effect anti-inflammatory properties anti-inflammatory property anti-SARS-CoV-2 antibody Anti-viral anti-viral effect anti-viral effects antibodies antibody antibody treatment benefit Cell combination therapy coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment Dexamethasone disease drugs Effect effective Efficacy exhibited hamster host responses immune responses Immunity Infection Inflammatory inflammatory cell lung Lungs mechanisms monoclonal antibody monoclonal antibody therapy Neutrophils potential mechanism prevented pulmonary pulmonary immune response recruitment respiratory SARS-CoV-2 scRNA-seq severe disease single-cell Standard-of-care subpopulation synergistic synergistic effects therapeutic option therapeutic options Therapies therapy transcriptomic transcriptomics Treatment Vaccine vaccine efficacy Vaccine hesitancy variants Viral viral burden was reduced [DOI] 10.1016/j.ymthe.2022.03.014 PMC 바로가기 [Article Type] Article