Cross-reactivity of eight SARS-CoV-2 variants rationally predicts immunogenicity clustering in sarbecoviruses8개의 SARS-CoV-2 변이체의 교차 반응성은 사베코바이러스의 면역원성 클러스터링을 합리적으로 예측합니다Article Published on 2022-07-272022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Administered Algorithm Analysis antigenicity Antisera Beta booster clade Clustering dose eight elicit evaluate guinea pigs Immune escape immune evasion immunized immunogens in silico information neutralization activity neutralize Neutralizing antibodies neutralizing antibody omicron other variants PIGS predict predicted pseudotyped quantification reduced Reinfection reported sarbecovirus Sarbecoviruses SARS-CoV-2 variant SARS-CoV-2 variants sera Spike protein Structure Vaccines variant variants variants of interest VoC VOCs VOI VOIs were used [DOI] 10.1038/s41392-022-01123-7 PMC 바로가기 [Article Type] Article
Longitudinal monitoring of SARS-CoV-2 spike protein-specific antibody responses in Lower AustriaLower Austria에서 SARS-CoV-2 스파이크 단백질 특이적 항체 반응의 종단적 모니터링Article Published on 2022-07-272022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activities activity Analysis analyzed antibody Antibody Response Community comprehensive view correlated COVID-19 eight hotspot IgA IgA level IgG IgG levels immune responses Immunoglobulin immunoglobulin A Infection infections longitudinal Lower participant Participants peptides positive reduction in remained reported SARS-CoV-2 SARS-CoV-2 spike significantly T cell the receptor-binding domain the spike protein Wachau [DOI] 10.1371/journal.pone.0271382 PMC 바로가기 [Article Type] Article
Post-vaccination antibody evaluation for nosocomial SARS-CoV-2 delta variant breakthrough infection병원 내 SARS-CoV-2 델타 변이형 돌발성 감염에 대한 백신 접종 후 항체 평가Observational Study Published on 2022-07-252022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-S IgG Anti-spike anti-spike antibody antibody Asymptomatic B.1.617.2 BNT162b2 booster vaccination Breakthrough infection Care Casirivimab characterized collected coronavirus Course Delta variants diagnosed Diagnosis eight estimation geometric mean geometric mean titer GMT hospital Humoral immunity IgG Imdevimab Infection Inpatient LAMP Loop-mediated isothermal amplification lowest measurement Mild mild to moderate mild to moderate severity moderate monoclonal antibody mRNA vaccination nosocomial observational study outbreak public health quantified RBD protein remained respiratory retrospective risk RT-PCR SARS-CoV-2 SARS-CoV-2 delta SARS-COV-2 infection SARS-CoV-2 vaccination Sequencing serological serum sample serum samples Seven severe acute respiratory syndrome Coronavirus severity therapy Treatment uninfected vaccination variant virus viruses was done whole-genome sequencing [DOI] 10.1371/journal.pone.0272056 PMC 바로가기 [Article Type] Observational Study
BioAutoML: automated feature engineering and metalearning to predict noncoding RNAs in bacteriaBioAutoML: 박테리아의 비코딩 RNA를 예측하기 위한 자동화된 기능 엔지니어링 및 금속 학습Article Published on 2022-07-182022-09-11 Journal: Briefings in Bioinformatics [Category] Coronavirus, 유전자 메커니즘, [키워드] accelerate Algorithm Algorithms Analysis approach automated automatically Bacteria benefit bioinformatics Care category components coronavirus disease Coronavirus disease 2019 coronavirus vaccine CRISPR develop Diseases domain Drug discovery Economy eight evaluate experimental results extraction feature Feature selection Features Health Health care helping housekeeping information knowledge machine learning mechanism ncRNA ncRNAs noncoding RNA Noncoding RNAs Precision predict Predictive Quantitative recent RECIPE reducing Regulatory selected sequence time-consuming translated tuning [DOI] 10.1093/bib/bbac218 PMC 바로가기 [Article Type] Article
Real-time allelic assays of SARS-CoV-2 variants to enhance sewage surveillance하수 감시를 강화하기 위한 SARS-CoV-2 변이체의 실시간 대립유전자 분석Article Published on 2022-07-152022-09-11 Journal: Water research [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] allele Allele-specific RT-qPCR allelic Alpha Analysis Beta Beta variant clinically Community sewage Concordance COVID-19 patient cross-reactivity Delta delta variant diagnosed discharged eight ENhance Gamma genotypes Hong Kong integration Lambda offer omicron Omicron variant outbreak provided qPCR quarantine real-time RT-qPCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sequence sewage Sewage surveillance specificity Surveillance variant variants Viral RNA whole-genome sequencing [DOI] 10.1016/j.watres.2022.118686 PMC 바로가기 [Article Type] Article
Urban monitoring, evaluation and application of COVID-19 listed vaccine effectiveness: a health code blockchain studyCOVID-19 등재 백신 효과의 도시 모니터링, 평가 및 적용: 건강 코드 블록체인 연구Article Published on 2022-07-132022-09-11 Journal: BMJ Open [Category] 변종, [키워드] aggravate Algorithm analysed Analysis Asymptomatic average basic reproduction number calculate city Complete conditions Contact cooperation country COVID-19 decrease deviation Effectiveness eight ENhance epidemiological Epidemiological investigation Epidemiology evaluate greater Health Health policy herd immunity Immunity increase Incubation period index infection rate information measure MONITOR mutant virus not decreased outcome Patient Primary outcome Primary outcomes promote promoted proportion protective effect reduced regions respond second significantly Simulation statistical symptomatic the vaccine this system transmitted urban urban population vaccination vaccination rate Vaccination strategy Vaccine Vaccines variant Variation virus weight [DOI] 10.1136/bmjopen-2021-057281 PMC 바로가기 [Article Type] Article
Technical performance of a lateral flow immunoassay for detection of anti-SARS-CoV-2 IgG in the outpatient follow-up of non-severe cases and at different times after vaccination: comparison with enzyme and chemiluminescent immunoassays중증이 아닌 환자의 외래 추적 관찰 및 백신 접종 후 다양한 시점에서 항-SARS-CoV-2 IgG 검출을 위한 측면 유동 면역분석의 기술적 성능: 효소 및 화학발광 면역분석과의 비교Article Published on 2022-07-132022-09-12 Journal: Revista do Instituto de Medicina Tropical de São [Category] MERS, 진단, [키워드] acute phase Analysis analyzed anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibody antibody production Blood booster dose chemiluminescent immunoassay children chose CLIA collected composed Coronavirus infections COVID-19 decrease diagnosed donors Efficiency eight enzyme expected Finger prick Follow-up healthcare healthy immunoassay immunochromatographic assay Infection lateral flow lateral flow immunoassay LFIA likelihood ratio Non-severe case NPV operator participant Pediatric patient performed positive PPV produced RT-PCR sensitivity serological Serological assay serum sample serum samples Seven specificity study group tested the antibody the vaccine three group true negative vaccination Variation volunteers Whole blood [DOI] 10.1590/S1678-9946202264049 PMC 바로가기 [Article Type] Article
ACTIVATE-2: A Double-Blind Randomized Trial of BCG Vaccination Against COVID-19 in Individuals at RiskACTIVATE-2: 위험에 처한 개인에서 COVID-19에 대한 BCG 백신 접종의 이중 맹검 무작위 시험Randomized Controlled Trial Published on 2022-07-052022-09-12 Journal: Frontiers in Immunology [Category] MERS, 임상, 진단, [키워드] 1:1 95% CI acute respiratory syndrome Against anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibodies approach Bacillus BCG BCG vaccination benefit clinical criteria Comorbidities controls coronavirus coronavirus disease COVID-19 COVID-19 pandemic develop Diagnosis double-blind trial Efficacy eight elderly vaccination end point evaluated Follow-up Hospitalization Immunity incidence of COVID-19 individual Infection Intervention Laboratory MOST multicenter Occurrence Older participant Patient patients older Placebo positive Randomized recipient reduced reduction respiratory infections Result risk SARS-CoV-2 the placebo group trained immunity Trial vaccination Vaccine Volunteer [DOI] 10.3389/fimmu.2022.873067 PMC 바로가기 [Article Type] Randomized Controlled Trial
Prolonged shedding of infectious viruses with haplotype switches of SARS-CoV-2 in an immunocompromised patient면역 저하 환자에서 SARS-CoV-2의 일배체형 스위치로 감염성 바이러스의 장기간 배출Case Reports Published on 2022-07-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] accumulated acquired immunity Bendamustine Clinical course Complete Complete Remission convalescent stage COVID-19 COVID-19 case COVID-19 infection COVID-19 pneumonia detectable eight episode episode of follicular Follicular lymphoma Haplotype Host immune Immunity Immunocompromised Immunocompromised host Immunocompromised patient Infectious virus infectiousness Infectivity initial kinetic long-lasting lymphoma management mechanical ventilation Non-synonymous mutation Patient Pneumonia Prolonged raised required Respiratory failure rituximab SARS-CoV-2 SARS-CoV-2 variants spike gene suppressed tested the SARS-CoV-2 variants Viral Viral kinetic. Viral RNA [DOI] 10.1016/j.jiac.2022.04.004 PMC 바로가기 [Article Type] Case Reports
COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records영국 성인 5,700만 명 사이의 COVID-19 궤적: 전자 건강 기록을 사용한 코호트 연구Article Published on 2022-07-012022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 신약개발, 진단, 치료기술, [키워드] Analysis can be used clinical pathways clinically Cohort cohort study collected COVID-19 COVID-19 phenotype COVID-19 testing COVID-19-related death Data science dataset death death certificate defined diagnose Diagnosis died disease severity disease trajectories disease trajectory EHR eight Electronic health record Electronic health records England estimate event Evidence evidence of FIVE foundation Frequency generate Health Data Research UK heart highest hospital Hospital admission ICU identify incidence individual individuals infection rate intensive care intensive care unit invasive ventilation MONITOR Mortality mortality data National Health Service NHS non-invasive ventilation occurred pandemic Pathways Patient patients Phenotypes positive primary care progression provided recorded remained SARS-CoV-2 test Science secondary care shown Stage stratified study period survival to define Trajectories trajectory vaccination Vaccination Status Ventilation ventilatory support Wave [DOI] 10.1016/S2589-7500(22)00091-7 PMC 바로가기 [Article Type] Article