From Syndemic Lesson after COVID-19 Pandemic to a “Systemic Clinical Risk Management” Proposal in the Perspective of the Ethics of Job Well DoneCommunication Published on 2021-12-212022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] aligned Bayesian approach Bayesian network big data clinical clinical risk management COVID-19 effective element enabling technologies Ethics event Health Service Health services IMPROVE Interpretation Intervention job learning lesson medical ethics observé occurred patient safety Quality quality of care Safety support for policy making sustainability syndemic systemic theory well WHO World Health Organization [DOI] 10.3390/ijerph19010015 PMC 바로가기 [Article Type] Communication
Implementation of a fully remote randomized clinical trial with cardiac monitoring Research Published on 2021-12-202022-10-05 Journal: Communications Medicine [Category] 임상, [키워드] activity adherence adverse event age AliveCor approach assigned cardiac monitoring clinical trial clinical trials conducted coronavirus disease COVID-19 COVID-19 disease criteria develop ECG ECGs electrocardiographic element Health Hydroxychloroquine hydroxychloroquine group implementation Inc. infectious risk investigator Laboratory mitigate MONITOR not differ occurred oxygen saturation pandemic participant Participants protocol QTc interval QTC prolongation randomized clinical trial recorded reported researcher respiratory rate Result Safe SARS-CoV-2 testing Sex Swab temperature the placebo group transmitted Treatment vital sign [DOI] 10.1038/s43856-021-00052-w [Article Type] Research
From asymptomatic to critical illness: decoding various clinical stages of COVID-19Article Published on 2021-12-172022-10-29 Journal: Turkish Journal of Medical Sciences [Category] COVID-19, SARS, [키워드] accompanied Acute heart failure Acute liver injury acute renal failure affected age ARDS Arrhythmias Asymptomatic average Bacterial C-reactive protein changes in Chest Chronic diseases Clinical course Clinical features clinical monitoring Clinical stage Coagulopathy Comorbidities Complication complications cough Course COVID-19 Critical D-dimer develop diarrhea disease disease severity disorders element Fatality rate ferritin Fever Fungal infection groups headache Hospitalized hospitalized patient immunosuppressants Immunosuppressed incidence include Insomnia intensive care Laboratory tests lung damage lymphopenia malaise Mild myalgia myocarditis Neuropsychiatric pathological change Patient patients Pneumonia poor prognosis Prognosis prothrombotic reported resulting risk risk factor Risk factors secondary Sepsis Septic shock Shortness of breath shown sore throat steroid Symptom Symptoms the patient therapy Thromboembolic events undergo venous [DOI] 10.3906/sag-2107-137 PMC 바로가기 [Article Type] Article
General and COVID-19-Related Mortality by Pre-Existing Chronic Conditions and Care Setting during 2020 in Emilia-Romagna Region, ItalyArticle Published on 2021-12-152022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] age Care care setting chronic chronic condition chronic conditions condition COVID-19 cross-sectional death deaths Deceased demographics element Emilia-Romagna estimate Europe excess female FIVE frailty heterogeneity highest include Italy men men and women metabolic Mortality mortality excess neuropsychiatric disease occurred pandemic prevalent Rate Ratio Region risk setting Sex socio-demographic understanding Variability [DOI] 10.3390/ijerph182413224 PMC 바로가기 [Article Type] Article
Understanding Gene Expression and Transcriptome Profiling of COVID-19: An Initiative Towards the Mapping of Protective Immunity Genes Against SARS-CoV-2 InfectionCOVID-19의 유전자 발현 및 전사체 프로파일링 이해: SARS-CoV-2 감염에 대한 보호 면역 유전자 매핑을 위한 이니셔티브Immunology Published on 2021-12-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Against Agilent Analysis Arraystar CASC18 Characteristics Cluster cluster analysis co-expression COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients dataset DEGs determine differentially expressed differentially expressed gene Differentially expressed genes disease pathogenesis DLEU2 element Gene Expression Genetic genetic factor GEO dataset globe GNAS healthy control healthy controls help identify immune immune response initiative inter-individual interactome mapping involved lncRNA mapping Microarray Mild molecular mechanism Pathway enrichment analysis performed Potential biomarker potential biomarkers PPI PPI network Profiling protective immunity protein-coding gene protein-coding genes protein-protein interaction Regulatory regulatory genes response responsible SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient SNHG20 statistical TALAM1 three groups transcriptome profiling UICLM understanding Variability volunteers was used [DOI] 10.3389/fimmu.2021.724936 PMC 바로가기 [Article Type] Immunology
mUzima Mobile Electronic Health Record (EHR) System: Development and Implementation at ScaleOriginal Paper Published on 2021-12-142022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, SARS, [키워드] approach atlas Cancer Care chronic disease Cohort Community conditions country COVID-19 developing countries development Digital digital divide Digital health domains EHR EHR system electrical electronic medical records element Evidence evidenced exacerbate extension feature Features global health Health health information highlight HIV implementation IMPROVE Intervention Kenya management media meet Mobile Mobile health objective patient data predominant principle provided Record Result robust scale scaled Support supported the WHO Uganda was used WHO WHO’ World Health Organization [DOI] 10.2196/26381 PMC 바로가기 [Article Type] Original Paper
The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshiftingArticle Published on 2021-12-102022-10-04 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, [키워드] Alter Antiviral Cell cellular dissect element enzyme expand Factor Frame frameshift Gene Expression Host identify impair in vitro inhibit inhibitor interact interfere isoform occur overexpression Protein proteome Regulation replicative RNA SARS-CoV-2 SARS-CoV-2 infected cells the SARS-CoV-2 These data transcript translation viral life cycle viral replication virulence virus viruses ZAP [DOI] 10.1038/s41467-021-27431-0 PMC 바로가기 [Article Type] Article
How an election can be safely planned and conducted during a pandemic: Decision support based on a discrete event modelResearch Article Published on 2021-12-092022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] caused Clusters condition conducted COVID-19 COVID-19 pandemic decision defined element event highest hygiene Infection limitation pandemic Precaution reduce required risk Safe significant increase splitting spread of COVID-19 Support turn Vienna while [DOI] 10.1371/journal.pone.0261016 PMC 바로가기 [Article Type] Research Article
COVID-19 and Venous Thromboembolism: From Pathological Mechanisms to Clinical ManagementReview Published on 2021-12-082022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] addition Anti-inflammatory drugs anticoagulant therapy antiplatelet Antithrombotic blood flow caused clinical Clinical prognosis clinical trial complex interaction controls Coronavirus disease 2019 COVID-19 COVID-19 patients critical COVID-19 patient disease severity Diseases drug drugs effective element Endothelial dysfunction Factor global pandemic Hospitalized hypercoagulability IMPROVE occur Occurrence outlined pathological pathological mechanism pathophysiological mechanism pathophysiology Prognosis risk factor SARS-COV-2 infection therapy thrombosis thrombotic thrombotic event Treatment treatments for COVID-19 Venous Thromboembolism Venous thrombosis VTE [DOI] 10.3390/jpm11121328 PMC 바로가기 [Article Type] Review
Immuno-Endocrinology of COVID-19: The Key Role of Sex HormonesCOVID-19의 면역 내분비학: 성 호르몬의 주요 역할Review Published on 2021-12-022022-09-11 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] Adaptive immune response androgen Clinical studies clinical study coronavirus coronavirus 2019 disease COVID-19 COVID-19 pathogenesis COVID-19 severity Cytopathic effect disease severity element Estrogen Evidence Factor Factors fatality Gender Gene regulation hormone hyper-inflammatory response identify immune response immune responses immuno-endocrinology include Infection Injury involved mechanism optimization Pathogenesis personalised regulated Regulation role SARS-CoV2 severity Sex sex hormone Sex hormones susceptibility target targets therapeutic intervention tissue injury tissue specific Treatment outcome Trial [DOI] 10.3389/fendo.2021.726696 PMC 바로가기 [Article Type] Review