Simple and label-free pathogen enrichment via homobifunctional imidoesters using a microfluidic (SLIM) system for ultrasensitive pathogen detection in various clinical specimens미세유체(SLIM) 시스템을 이용한 동종 이기능성 이미도에스터를 통한 간단하고 라벨 없는 병원체 농축으로 다양한 임상 샘플에서 초민감 병원체 검출Article Published on 2018-04-032023-05-31 Journal: Biosensors & bioelectronics [Category] Fulltext, 대상포진, 두창, 수두, 홍역, [키워드] Clinical specimens enrichment Microfluidic system Pathogen diagnosis point-of-care testing [DOI] 10.1016/j.bios.2018.04.001 PMC 바로가기 [Article Type] Article
A case-control collapsing analysis identifies epilepsy genes implicated in trio sequencing studies focused on de novo mutations사례 대조 붕괴 분석은 새로운 돌연변이에 초점을 맞춘 트리오 시퀀싱 연구와 관련된 간질 유전자를 식별합니다Research Article Published on 2017-11-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition adopted Analysis approach can be used Case-control Collapsing controls datasets de novo de novo mutation de novo mutations disease disorders dominant effective enrichment epilepsy epileptic encephalopathy evaluate Exome expected filtered form Genes genome-wide significance identify implicated KCNT1 large cohort life majority Mutation offer parent parents pathogenic performed predicted proportion Protein protein-coding gene protein-coding genes rare variant responsible Sample size sample sizes SCN2A selected sequence Sequencing significantly significantly higher STXBP1 Support Trio variant variants Variation [DOI] 10.1371/journal.pgen.1007104 PMC 바로가기 [Article Type] Research Article
Evaluation of microplate immunocapture method for detection of Vibrio cholerae , Salmonella Typhi and Shigella flexneri from food식품에서 콜레라균, 장티푸스균 및 시겔라 플렉스네리 검출을 위한 마이크로플레이트 면역포획 방법 평가Research Article Published on 2017-08-292024-07-30 Journal: BMC Microbiology [Category] 세균성이질, [키워드] detection enrichment food Immunocapture Microplate pathogen [DOI] 10.1186/s12866-017-1099-y PMC 바로가기 [Article Type] Research Article
Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulationMycobacterium leprae 항원 자극 후 유전자 발현의 유전자 제어 해독Research Article Published on 2017-08-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 한센병, [키워드] activated Affect Antigen bacterium binding site Blood cells caused conducted criteria Differential gene expression disease disease control displaying enrichment eQTL Evidence exposure to expression FDR Gene Expression gene expression level Genetic genetic control Genetic variation Genetic variations genomic highlight Host host genetics host response host responses human host human infectious disease immune Immune cell immune cells Infection Infectious disease Interaction involved knowledge leprosy loci mechanism modulate modulation Mycobacterium leprae natural selection nucleotide outlined pathogen Pathogenesis pathogenicity Patient performed Positive selection proportion Quantitative reaction Regulatory reported Seven significantly Single nucleotide polymorphism single nucleotide polymorphisms SNPs Stimulation suggested susceptibility the disease transcript transcription factor transcription factors transcriptional response triggered upregulation variant variants Variation while whole blood cell whole blood cells [DOI] 10.1371/journal.pgen.1006952 PMC 바로가기 [Article Type] Research Article
Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations단일 특성 및 다중 특성 게놈 전체 연관 분석을 통해 아프리카 계통 인구의 혈압에 대한 새로운 유전자좌 식별Research Article Published on 2017-05-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect African African American African Americans allele alleles analyses Analysis analyzed angiotensin biologic blood pressure CDH17 cells complications conducted contributing to Diastolic blood pressure disability disease driven by enrichment Evidence experimental models expressed expression Factor FRMD3 functional annotation Genes Genetic studies genome-wide association Genome-wide association study genome-wide significance genomic region Health health problem hypertension identify immune independent individual kidney kidney tissue LLPH loci locus mice Mortality mRNA expression nine performed Population populations provide reached reported Research risk Support susceptibility susceptibility loci systolic TARID TCF21 TMBIM4 traits variant Vascular while [DOI] 10.1371/journal.pgen.1006728 PMC 바로가기 [Article Type] Research Article
Tunable and label-free virus enrichment for ultrasensitive virus detection using carbon nanotube arraysArticle Published on 2016-10-072023-06-03 Journal: Science Advances [Category] Fulltext, 조류인플루엔자, [키워드] carbon nanotubes enrichment field samples improved detection Influenza N-doped NGS PCR sensor virus [DOI] 10.1126/sciadv.1601026 PMC 바로가기
Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway죽상경화증 퇴행 동안 플라크 대식세포의 전사체에 대한 후성유전체 분석은 Wnt 신호 전달 경로의 활성화를 보여줍니다Research Article Published on 2014-12-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Affect Analysis annotations approach arterial plaque macrophage arteries Atherosclerosis binding site canonical Cell cell motility cell type chromatin circulating condition control group demonstrated detect differentially expressed drug treatments eight element enrichment epigenomic eQTL Evidence expression foam cell functional Gene Expression humans identify in vitro in vivo increase Inflammation inflammatory disease inflammatory state innate immune system less Lipoproteins lowering Macrophage Macrophage response macrophage responses macrophages mice Migration molecular mouse model network overlap plaque plaque macrophage plaque macrophage response plaque macrophage responses plaque macrophages plaque regression plaques plasma lipoprotein plasma lipoproteins power promoter promoters reducing regressing plaque regressing plaques Regression Regression model regression models regulatory region response reversed risk significantly SNPs statins statistically Stimulation Systems biology TCF/LEF therapeutic target transcription factor transcription factors transcriptional change Transcriptome upregulated upregulated gene upregulated genes upstream validation study while Wnt Wnt signaling Wnt signaling pathway β-catenin [DOI] 10.1371/journal.pgen.1004828 PMC 바로가기 [Article Type] Research Article
Label-free microfluidic enrichment of ring-stage Plasmodium falciparum -infected red blood cells using non-inertial hydrodynamic lift비관성 유체역학적 리프트를 이용한 링 단계 말라리아 원충 감염 적혈구의 라벨 없는 마이크로유체 농축Methodology Published on 2014-09-202024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] enrichment erythrocytes Lab-on-a-chip malaria microfluidic Non-inertial lift Plasmodium falciparum red blood cells Ring stage [DOI] 10.1186/1475-2875-13-375 PMC 바로가기 [Article Type] Methodology
A Novel Highly Divergent Protein Family Identified from a Viviparous Insect by RNA-seq Analysis: A Potential Target for Tsetse Fly-Specific AbortifacientsRNA-seq 분석을 통해 태생 곤충에서 식별된 매우 다양한 새로운 단백질 패밀리: 체체 파리 관련 낙태 환자의 잠재적 표적Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Abortifacient addition African Amino acid amino acid sequence Analysis approaches casein cattle causative agents characterization coding control mechanisms Critical Differential analysis enrichment Factor family fecundity female functional genes encoding Genome genomic homeostasis Human Identified identify indicate insect Interference knockdown lactating lactation lipid metabolism maintenance mammalian mechanism mechanisms metabolism mother s milk novel occur organized Potential progeny Protein protein level protein synthesis Proteins proteome provided reduce reduced reducing Region reproductive resource RNA-Seq RNA-seq data secretion sequence similarity Seven shown similarities sleeping sickness specificity suppression synthesis target to define transcript Transcriptome transcripts Transferrin tsetse tsetse flies tsetse fly unique variant Viviparous were expressed while [DOI] 10.1371/journal.pgen.1003874 PMC 바로가기 [Article Type] Research Article
Combining Quantitative Genetic Footprinting and Trait Enrichment Analysis to Identify Fitness Determinants of a Bacterial Pathogen정량적 유전 발자국과 특성 강화 분석을 결합하여 세균성 병원체의 적합성 결정 요인 식별Research Article Published on 2013-08-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major abundance Affect Algorithm Antibiotic resistance approach approaches array assortment Author Bacterial bacterial gene bacterial genes benefit bioinformatics candidate gene changes in Combination conjunction conserved dataset deep sequencing deleted determinant determinants Determining diagnostic dissect Diversity DNA binding E. coli effective effort enrichment Escherichia Escherichia coli Factor fitness Follow-up analysis Footprinting found Gene Genes Genetic Genome genomes highest highlight homologue homologues Host hypothetical identify increasingly independent Infection infections insertion investigator investigators isolates Meningitis molecular mouse model Mutagenesis mutant novel observation observations pathogen Pathogenesis pathogenic pathogenic strain pathogenic strains Pathogens phenotypic phenotypic variation phylogenetic distribution promote Quantitative reported required Research resource saturated Sepsis Sequencing shown strain Strains suggested therapeutic therapeutic targets Therapies Tn-seq to define trait transcriptional repressor transposon urinary tract infections variant Variation virulence virulence gene widespread zebrafish [DOI] 10.1371/journal.pgen.1003716 PMC 바로가기 [Article Type] Research Article