Association between HLA-C alleles and COVID-19 severity in a pilot study with a Spanish Mediterranean Caucasian cohort스페인 지중해 백인 코호트를 대상으로 한 파일럿 연구에서 HLA-C 대립형질과 COVID-19 심각성 사이의 연관성Article Published on 2022-08-122022-09-11 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, [키워드] age allele analyzed antiviral response association Asymptomatic cause Cell cell surface class Clinical characteristics clinical presentation Clinical presentations Cohort Comorbidity contrary COVID-19 COVID-19 severity Critical described determine disease epitope Epitopes expressed Factor fatal disease Gender groups HLA HLA allele HLA alleles HLA class I HLA-A HLA-B HLA-B allele HLA-B alleles HLA-C HLA-C allele HLA-C alleles HLA-C1 Host hyperinflammatory state immune response individual Infection involved KIR gene male management mechanism Mild mild infection no significant difference no significant differences outcomes pandemic peptide peptides pilot study recruited SARS-CoV-2 protein SARS-CoV-2 proteins significant difference significant differences small sample size Spain Spanish T cells β2-microglobulin [DOI] 10.1371/journal.pone.0272867 PMC 바로가기 [Article Type] Article
ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodiesACE2 결합은 코로나바이러스 항체를 광범위하게 중화시키는 SARS-CoV-2 융합 펩타이드를 노출시킵니다Article Published on 2022-08-122022-09-11 Journal: Science (New York, N.y.) [Category] COVID19(2023년), MERS, SARS, 비임상, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Alpha alpha- Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal coronavirus Animal coronaviruses antibody approach betacoronaviruses binding breadth breath conserved coronavirus coronavirus spike protein donors enzyme epitope functional fusion peptide hidden host receptor Host receptors immune in vitro in vivo mAb mAbs monoclonal antibodies monoclonal antibody motif neutralize Neutralizing Neutralizing activity omicron pathology peptide prefusion recognize reduce respiratory SARS-CoV-2 selected Seven severe acute respiratory syndrome Coronavirus somatic mutations spike glycoprotein Spike proteins the SARS-CoV-2 Viral viral burden virus viruses [DOI] 10.1126/science.abq2679 PMC 바로가기 [Article Type] Article
Broadly neutralizing antibodies target the coronavirus fusion peptide광범위 중화 항체는 코로나바이러스 융합 펩티드를 표적으로 한다Article Published on 2022-08-122022-09-12 Journal: Science (New York, N.y.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome Alpha antibodies antibody approach arginine residue betacoronaviruses caused cleavage site conserved coronavirus coronavirus vaccine Coronaviruses crystal structure disease epitope fusion peptide helical structure highlight identify include monoclonal antibody neutralize neutralizing antibody omicron outbreak Pathogens Receptor binding SARS-CoV-2 Seven Spike protein the SARS-CoV-2 [DOI] 10.1126/science.abq3773 PMC 바로가기 [Article Type] Article
Anti-neuronal antibodies against brainstem antigens are associated with COVID-19Article Published on 2022-08-112022-10-05 Journal: EBioMedicine [Category] SARS, 바이오마커, 변종, 진단, 치료기술, [키워드] Affect AIFM1 antibody Antigen appear assisted ventilation Autoimmunity Brainstem Control controls Course COVID-19 patient COVID-19 patients DAB1 determine diagnostic Disabled Economy elevated Encephalitis epitope Epitopes finding foundation funding Germany Greifswald group help homolog hypothesised IgG IgG and IgM IgG level IgM implicated in both groups initiative intensive care Invasion long-COVID marker Medicine Microarray Mild Occurrence pathogenic pathway Patient peptide epitope predicted responsible SARS-CoV-2 serum severe disease severely ill patient significantly state Support SURF1 the disease therapeutic understanding university unlikely with COVID-19 [DOI] 10.1016/j.ebiom.2022.104211 [Article Type] Article
Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA.1/BA.1.1/BA.2/BA.3SARS-CoV-2에 대한 현재 이용 가능한 인간 중화 항체의 아틀라스 및 Omicron 하위 변이체 BA.1/BA.1.1/BA.2/BA.3에 의한 탈출Article Published on 2022-08-092022-09-11 Journal: Immunity [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody Atla complex COVID-19 decreased activity Efficacy epitope facilitate G446S mutation human monoclonal antibodies Human monoclonal antibody human neutralizing antibodies Immune escape immune evasion lack mAb mAbs Mutation Neutralizing neutralizing activities neutralizing antibody Neutralizing assay neutralizing assays omicron Omicron BA.1 Omicron BA.1.1 Omicron BA.2 Omicron BA.3 provided RBD SARS-CoV-2 SARS-CoV-2 RBD sensitivity Seven the SARS-CoV-2 therapeutic Vaccine Vaccines variant variants [DOI] 10.1016/j.immuni.2022.06.005 PMC 바로가기 [Article Type] Article
Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal modelsArticle Published on 2022-08-052022-10-06 Journal: Science (New York, N.y.) [Category] SARS, 조류인플루엔자, 진단, [키워드] acute respiratory syndrome animal model antibody Betacoronavirus conserved coronavirus demonstrated elicit elicited epitope Health immune response immunization immunodominant macaque mice mosaic neutralization PROTECT Randomly RBD RBDs response sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Seven spike receptor-binding domain Strains variant [DOI] 10.1126/science.abq0839 PMC 바로가기 [Article Type] Article
Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies자연적으로 유도된 항-SARS-CoV-2 항체에 의한 SARS-CoV-2 중화의 구조적 유연성Article Published on 2022-08-052022-09-11 Journal: Communications Biology [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding site Alpha anti-RBD anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody Arm array Beta bind binding conformations convalescent Cross linking cross-neutralizing Culture Delta Donor elicited epitope evaluate exhibit FIVE flexible Gamma likelihood mAb mAbs mechanism molecular monoclonal antibodies monoclonal antibody mutated neutralization neutralize Neutralizing nine omicron Proteins provide pseudoviruses RBD Receptor binding domain recruited SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike trimer SARS-CoV-2 variants Spike protein Spike proteins spike trimer Structure structures subunits tested the RBD the SARS-CoV-2 unique variant variants of concern variants of SARS-CoV-2 Viral viral evolution virus viruses VoC VOCs wild type Wuhan-Hu-1 [DOI] 10.1038/s42003-022-03739-5 PMC 바로가기 [Article Type] Article
Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope우성 SARS-CoV-2 킬러 T 세포 에피토프에서 면역 탈출의 출현Article Published on 2022-08-042022-09-11 Journal: Cell [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen CD8 CD8 T cell Cohort cohorts convalescent patient Convalescent patients coronavirus COVID-19 dominant emergence epitope Epitopes for inclusion Frequency glycoprotein highlighting HLA human leukocyte antigen immune Immune escape individual leukocyte Lineage lineages mounted Mutation new SARS-CoV-2 Next generation vaccine next generation vaccines peptide-HLA Phylogenetic prevalent Protein response SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 spike SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus spike spike glycoprotein T cell T cell epitope T cell epitopes T cell receptors vaccine immunity variants viral escape Viral protein Viral proteins [DOI] 10.1016/j.cell.2022.07.002 PMC 바로가기 [Article Type] Article
Isolation and characterization of phage display-derived scFv antibodies against human parechovirus 1 VP0 protein Research Published on 2022-08-042022-10-05 Journal: Scientific Reports [Category] 진단, [키워드] antibodies antibody Central nervous system clone clones comparison conformational conserved diagnostic disease dominant E. coli ELISA enzyme-linked immunosorbent epitope flanking region GenBank generate Human IFA immunofluorescence microscopy Infection infections isolate isolates Isolation Mild peptide positive Protein purified representing respiratory symptom scFv sequence tested unique variety virus virus sample was used [DOI] 10.1038/s41598-022-17678-y [Article Type] Research
A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike공개 항체 클래스는 SARS-CoV-2 스파이크의 개방형 구조에 노출된 S2 에피토프를 인식합니다.Article Published on 2022-08-042022-09-12 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] antibody approved average B cell benefit Complete conformation Critical elicited epitope flow cytometry fraction help individual memory memory B cell phenotype pre-fusion receptor recognize S protein S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccines Sequencing single-cell target the SARS-CoV-2 vaccination Vaccine [DOI] 10.1038/s41467-022-32232-0 PMC 바로가기 [Article Type] Article