Remdesivir shifts circadian rhythmicity to eveningness; similar to the most prevalent chronotype in ADHDPsychiatry and Preclinical Psychiatric Studies - Original Article Published on 2021-07-172022-10-29 Journal: Journal of neural transmission (Vienna, Austria : [Category] COVID-19, [키워드] Alter analysed circadian rhythm Cohort Culture Dexamethasone Diagnosis Effect Efficacy Ex vivo expression fibroblast Gene Expression had no Human dermal fibroblasts Immunity indicated medication Neuropsychiatric participant prevalent qRT-PCR Remdesivir Significant significant difference sleep quality synchronization virus replication [DOI] 10.1007/s00702-021-02375-3 PMC 바로가기 [Article Type] Psychiatry and Preclinical Psychiatric Studies - Original Article
Plitidepsin: Mechanisms and Clinical Profile of a Promising Antiviral Agent against COVID-19Review Published on 2021-07-162022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] accelerate acting administration affected agent anti-SARS-CoV-2 anticipated Antiviral Antiviral agents Antiviral effect antiviral property aplidin B.1.1.7 variant clinical Clinical data clinical evidence Combination COVID-19 current database demonstrated Dexamethasone effective Efficacy Ex vivo hospital hospitalized COVID-19 patients hospitalized patients Host inhibiting interactions intravenous isoform knowledge lack lineages mechanism multicentre Multiple myeloma Patient Plitidepsin Population profile regimen Remdesivir safety profile SARS-CoV-2 Standard of care standard treatment suggested translation Treatment Trial viral load reduction Viral proteins [DOI] 10.3390/jpm11070668 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Infects Endothelial Cells In Vivo and In VitroSARS-CoV-2는 생체 내 및 시험관 내 내피 세포를 감염시킵니다Cellular and Infection Microbiology Published on 2021-07-062022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료기술, [키워드] ACE-2 activated Ad5-hACE2 addition Adenovirus Affect animal models aorta ring cardiovascular complication cardiovascular complications cause CD31 CD34 cellular activation characterized Comparative analysis contribute cytokine Cytokine storm demonstrated died dysfunction edema electron microscopic analysis Endothelial cell endothelial cell infection endothelial cells endotheliopathy Ex vivo exposure to expressing focus hACE2 hemorrhage immunostaining in vivo infect infecting Inflammatory inflammatory cascade intranasal KRAS labeling Localization lung Lung pathology lung tissue Lungs marker mice microscopic analysis non-human primate non-human primates other organs pathway Patient Pneumocytes positive Protein RNA RNA sequencing data SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins severe COVID-19 signaling pathway thrombosis upregulated vascular endothelial cell vascular inflammation vascular permeability Viral viral particle Viral particles [DOI] 10.3389/fcimb.2021.701278 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Replicative Fitness of a SARS-CoV-2 20I/501Y.V1 Variant from Lineage B.1.1.7 in Human Reconstituted Bronchial Epithelium인간 재구성 기관지 상피에서 혈통 B.1.1.7의 SARS-CoV-2 20I/501Y.V1 변이체의 복제 적합성Observation Published on 2021-07-062022-09-10 Journal: mBio [Category] MERS, SARS, 변종, [키워드] 20I/501Y.V1 B.1.1.7 both virus both viruses bronchial Bronchial epithelium cellular Characteristics circulating competition contribute coronavirus CoV D614G epithelium European Evidence Ex vivo experiment fitness genetic diversity Human in vitro Lineage Lineage B.1.1.7 New coronavirus no difference phenotypic Population regions replaced replicate Replication replication kinetics replicative fitness respiratory Result SARS-CoV-2 strain variant viruses [DOI] 10.1128/mBio.00850-21 PMC 바로가기 [Article Type] Observation
Absence of SARS-CoV-2 Antibodies in Natural Environment Exposure in Sheep in Close Contact with HumansArticle Published on 2021-07-022022-10-28 Journal: Animals : an Open Access Journal from MDPI [Category] COVID-19, [키워드] absence acute respiratory syndrome alphacoronavirus analyzed anti-SARS-CoV-2 antibodies Antigen caused close contact Community composed conditions contact with coronavirus coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 Culture detect ELISA Environment enzyme-linked immunosorbent epidemiological Epidemiology Evidence Ex vivo exposure ferret Future Human Infection infections information knowledge natural no statistical difference organ pandemic patients Prevalence RBD replicate ruminant ruminants SARS-CoV-2 SARS-COV-2 infection serology Serosurvey serum sample sheep simple Spread susceptibility susceptible tested the antibody response the receptor-binding domain Transmissibility unlikely wild animals with COVID-19 zoonotic [DOI] 10.3390/ani11071984 PMC 바로가기 [Article Type] Article
A pilot study to assess the circulating renin-angiotensin system in COVID-19 acute respiratory failureClinical Trial Published on 2021-07-012022-10-05 Journal: American journal of physiology. Lung cellular and [Category] SARS, 임상, [키워드] ACE ACE2 acute respiratory distress acute respiratory distress syndrome Alternative pathway ANG angiotensin angiotensin-converting enzyme 2 Anti-inflammatory cellular entry circulating clinical trial clinical trials Cohort cohorts component Concentration conducted Control controls COVID-19 Critical Critical care Degradation demonstrated Enrollment Ex vivo Hypothesis hypoxic respiratory failure ICU increased mortality Interaction laboratory assays Mild moderate Multiple no significant difference outcomes pathway Patient patients with moderate peptidase peptide physiological pilot study proinflammatory prolonged intensive care RAS reduction in renin-angiotensin system Respiratory failure SARS-CoV-2 severe COVID-19 severe COVID-19 cohort severity Signaling the SARS-CoV-2 virus were measured [DOI] 10.1152/ajplung.00129.2021 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 specific T-cell immunity in COVID-19 convalescent patients and unexposed controls measured by ex vivo ELISpot assay코로나19 회복기 환자 및 노출되지 않은 대조군의 SARS-CoV-2 특이적 T 세포 면역성을 생체외 ELISpot 분석으로 측정Article Published on 2021-07-012022-09-12 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 진단, [키워드] accompany CD4 CD4 T cells CD8 T cell characterized Cohort Control convalescent Coronaviruses COVID-19 COVID-19 convalescent patient COVID-19 infection Donor ELISPOT ELISpot assay Ex vivo humoral Humoral response immune protection Infection median mononuclear cell Neutralizing antibodies neutralizing antibody Patient PBMCs Peripheral blood positive positive correlation positive response positive result quantified SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 neutralizing antibodies serum samples subject subjects Symptom symptom onset T-cell immunity T-cell Response the SARS-CoV-2 titre undetectable uninfected was performed [DOI] 10.1016/j.cmi.2021.03.010 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epitheliumSARS-CoV-2는 인간 성인 기증자의 눈과 hESC 유래 안구 상피를 감염시킵니다.Article Published on 2021-07-012022-09-11 Journal: Cell Stem Cell [Category] SARS, 치료기술, [키워드] ACE2 aerosol transmission Analysis antigen expression cadaver caused Cell Cornea COVID-19 COVID-19 patient Culture Donor Ex vivo eye infect infected cell infected cells Infection interferon interferon signaling life limbus mechanism NF-κB ocular Ocular surface organoid cultures portal Post-mortem productive viral replication regions robust SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 pandemic scRNA-seq Spread stem cells These data thought tissue Transmission viral entry viral particle Viral particles while [DOI] 10.1016/j.stem.2021.04.028 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cellsSARS-CoV-2 특이 T 세포 기억은 줄기 세포 유사 기억 T 세포의 성공적인 개발로 COVID-19 회복기 환자에서 10개월 동안 지속됩니다.Article Published on 2021-06-302022-09-12 Journal: Nature Communications [Category] MERS, SARS, 진단, 치료기술, [키워드] activation-induced markers Antimicrobial responses CD4 CD8 Cell cells contribute convalescent COVID-19 patients COVID-19 COVID-19 convalescent patient COVID-19 pandemic detectable development differentiation effective evaluate Ex vivo feasibility immune responses Immunity Immunological memory long-lasting Longevity measure memory memory T memory T cell memory T cells MHC-I observé pathogen peaking post-symptom onset proliferation proportion protective immune response Re-infection response responsible SARS-CoV-2 SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells severity of COVID-19 staining stem cell study period Support sustained T cell T cell memory T cell response T cell responses T cells vaccination viral clearance viral infection [DOI] 10.1038/s41467-021-24377-1 PMC 바로가기 [Article Type] Article
Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severityResearch Article Published on 2021-06-162022-10-04 Journal: Science Advances [Category] MERS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome ameliorated Apoptosis attenuate Combination coronavirus Coronavirus infection demonstrated disease disease severity Endoplasmic reticulum Evidence Ex vivo hACE2 highly pathogenic human Angiotensin-converting enzyme in vitro in vivo in vivo models Infection intrinsic lung damage mechanism MERS MERS-CoV mice Middle East Pathogenesis pathway physiological proapoptotic signal Protein provide reduce respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 Signaling targeting Trigger viral pathogenesis [DOI] 10.1126/sciadv.abf8577 PMC 바로가기 [Article Type] Research Article