frequencies – Page 11 – Communicable Diseases Research

Disease control across urban–rural gradients

도시-농촌 구배에 걸친 질병 통제

1004

Published on 2020-12-092022-09-10
Journal: Journal of the Royal Society Interface [Category] MERS, SARS, 치료기술, 치료제,

COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes

COVID-19 심각도는 CD1c+ DC 및 염증성 이행 및 비고전 단핵구의 폐 재분포와 관련이 있습니다.

Clinical Trial

Published on 2020-12-012022-08-31
Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 바이오마커, 임상,

[키워드] Activation acute respiratory distress acute respiratory distress syndrome addition Antiviral ARDS association Blood CD1c CD8+ T cell CD8+ T cells characterized Clinical severity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 severity critical COVID-19 patients dendritic cell dendritic cells disease dysregulated immune response dysregulated immune responses frequencies Frequency healthy individuals immune responses immunology increase infected individuals Inflammation Inflammatory involved knowledge life-threatening lung lung infiltrate lung infiltrates Lungs Mild symptom mild symptoms monocyte Monocytes myeloid cell occur Pathogenesis pathogenesis of COVID-19 Patient profile progression respiratory distress Respiratory distress syndrome responsible SARS-CoV-2 SARS-COV-2 infection severe COVID-19 subpopulation subset syndrome T cell T cells Therapeutic strategies therapeutic strategy Viral viral control
[DOI] 10.1172/JCI140335 PMC 바로가기 [Article Type] Clinical Trial

Baricitinib restrains the immune dysregulation in patients with severe COVID-19

Clinical Trial

Published on 2020-12-012022-10-05
Journal: The Journal of Clinical Investigation [Category] SARS, 임상,

[키워드] anti-SARS-CoV-2 antibody antibody production approved B cell Baricitinib blood cell change circulating Clinical outcome clinically coronavirus disease correlated COVID-19 cytokine level cytokine release develop Disabled evaluated Evidence expression extreme fraction frequencies functional IL-1β IL-6 immune immune dysregulation Immune phenotype Immunity immunology increase in Inflammatory response Innate Innate immunity JAK/STAT signaling Local lymphopenia modulating myeloid cell need for oxygen off-label oxygen P/F PaO2 Pathways Patient patients treated patients with COVID-19 per day phosphorylated Pneumonia prevented progression reduction in regulated Serum level severe COVID-19 Spike protein STAT3 supported the patient the SARS-CoV-2 therapy TNF-α transcriptionally treated Trial viral disease
[DOI] 10.1172/JCI141772 PMC 바로가기 [Article Type] Clinical Trial

Attitudes and precaution practices towards COVID-19 among pregnant women in Singapore: a cross-sectional survey

Research Article

Published on 2020-11-102022-10-28
Journal: BMC Pregnancy and Childbirth [Category] COVID-19,

[키워드] 95% CI age Antenatal Attitude Attitudes Chinese clinician clinics Complete conducted COVID-19 COVID-19 outbreak cross-sectional cross-sectional survey demographical factor demographics employment frequencies Frequency global pandemic Google greater high risk higher risk independent Linear regression analysis majority measure Mental Multiple Multiple linear regression Neonatal non-infected outcome pandemic platform practices Precaution pregnant pregnant women provided psychological support question response Result Safe severe disease Singapore social distancing socio-demographic supplementary material survey variables was performed women
[DOI] 10.1186/s12884-020-03378-w PMC 바로가기 [Article Type] Research Article

SARPPIC : Exploiting COVID-19 Contact Tracing Recommendation through Social Awareness

Research Article

Published on 2020-11-102022-10-31
Journal: Computational and Mathematical Methods in Medicine [Category] COVID-19, MERS,

Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations

3067 SARS-CoV-2 게놈의 대규모 게놈 분석을 통해 핫스팟 돌연변이의 클론 지리 분포와 풍부한 유전적 변이가 밝혀졌습니다.

Research Article

Published on 2020-11-102022-08-13
Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘,

[키워드] accumulation Affect allele Analysis analyzed characterization China collected Comparative genomics country COVID-19 database distribution Evolution frequencies Frequency Genetic variant genetic variants Genetic variation Genomic analysis Genotype geographic location geographic locations global pandemic haplotypes hotspot mechanism mutated Mutation mutations Non-synonymous Non-synonymous mutation phylogeographic analysis Prevalence profile profiles recurrent mutation residue resulting reveal SARS-CoV-2 SARS-CoV-2 genes SARS-CoV-2 genome SARS-CoV-2 genomes selected selective severity shown Spread the epidemic the SARS-CoV-2 the SARS-CoV-2 genome therapeutic targets variant Viral viral infection virus whole-genome Wuhan Wuhan, China
[DOI] 10.1371/journal.pone.0240345 PMC 바로가기 [Article Type] Research Article

Does Working in a COVID-19 Receiving Health Facility Influence Seroprevalence to SARS-CoV-2?

Preventive Medicine

Published on 2020-11-092022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] A p-value acute respiratory syndrome antibodies antibody association category checked conducted Contact coronavirus coronavirus disease COVID-19 cross-sectional doffing donning facility frequencies HCW health care workers healthcare facility healthcare worker highest hospital hospitals immunoassay influence logistic regression model no significant difference Non-COVID-19 Nurse objective Patient Personal protective equipment positive PPE predict proportion protocol random receiving recruited Result SARS-CoV-2 SARS-CoV-2 antibody seropositive Seroprevalence significantly higher statistically significant stratified Switzerland variable was used with COVID-19 working
[DOI] 10.7759/cureus.11389 PMC 바로가기 [Article Type] Preventive Medicine

Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of Outcome

ACE2 변이의 스펙트럼 분석은 COVID-19에 대한 감수성과 결과의 심각성에 대한 희귀 및 공통 변이의 가능한 영향을 시사합니다

Genetics

Published on 2020-09-292022-08-13
Journal: Frontiers in Genetics [Category] 유전자 메커니즘,

[키워드] ACE2 ACE2 variant ACE2 variants acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect allele frequency alternative allele analyzed angiotensin angiotensin-converting enzyme-2 caused Cohort common coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dataset disease severity eQTL European population European populations explain frequencies Frequency Genetic variant genetic variants Genome Aggregation Database gnomAD gnomAD database Health Organization influence Missense missense variant mutations objective outcome pandemic Patient patients with COVID-19 Regulatory respiratory Respiratory disease Result rs146598386 rs73195521 rs755766792 Russia Russian population severity Severity of disease Southern European population Spectrum statistical Support susceptibility variant variants whole-exome sequencing World Health Organization
[DOI] 10.3389/fgene.2020.551220 PMC 바로가기 [Article Type] Genetics

S Protein-Reactive IgG and Memory B Cell Production after Human SARS-CoV-2 Infection Includes Broad Reactivity to the S2 Subunit

Research Article

Published on 2020-09-252022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] accompanied acute respiratory syndrome Analysis analyzed anti-N IgG anti-S2 antibody antibody production asked B cell B cell response circulating conserved convalescent coronavirus coronavirus disease correlated strongly COVID-19 cross-reactive disease ENhance frequencies generate healthy donor Human human coronavirus OC43 IgG IgG antibodies IgG level IgG titer immune memory immune protection Immunity individuals Infection MBC memory B cell memory B cells mononuclear cell MOST non-SARS-CoV-2 protein nucleocapsid pandemic PBMCs Peripheral blood Population Postinfection Production Protein provide RBD reactive Receptor binding domain reflect Reinfection S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins sera specificity Spike protein Spread subject subjects susceptibility susceptible the RBD the S protein the SARS-CoV-2 virus Virus-specific IgG
[DOI] 10.1128/mBio.01991-20 PMC 바로가기 [Article Type] Research Article

Neurological symptoms in acute COVID-19 infected patients: A survey among Italian physicians

Research Article

Published on 2020-09-112022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS,

[키워드] Abnormalities abnormality acute COVID-19 affected analyzed category chi-square test clinician concerning coronavirus COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients defined Diagnosis Diseases distribution evaluated frequencies headache help Interpretation involved Italian Italy management material measure median Mild myalgia nervous system Neurological symptom Neurological symptoms nine no difference non-specific objective Occurrence outbreak outcome pandemic pandemic disease Pathogenesis patients physician Physicians Practitioner promote question Region reported Research response Result SARS-CoV-2 virus Symptom therapeutic approaches Trial was used
[DOI] 10.1371/journal.pone.0238159 PMC 바로가기 [Article Type] Research Article