Development of recombinant vaccine candidate molecule against Shigella infection시겔라 감염에 대한 재조합 백신 후보 분자의 개발Article Published on 2016-10-172024-08-22 Journal: Vaccine [Category] 세균성이질, [키워드] fusion protein groEL IpaB S. Typhi Shigella [DOI] 10.1016/j.vaccine.2016.08.034
Immunogenicity and protective efficacy of recombinant fusion proteins containing spike protein of infectious bronchitis virus and hemagglutinin of H3N2 influenza virus in chickensArticle Published on 2016-08-032022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] bronchitis Cellular immune response contagious cytoplasmic tail demonstrated disease Efficacy Epitopes fused fusing fusion protein fusion proteins generate group H3N2 humoral IBV immunization immunized immunogenicity inactivated Infectious Bronchitis Virus Influenza virus injected inoculated M41 Protective protective immune response Protein recombinant fusion protein Recombinant S1 protein robust S1 protein significantly higher Spike protein transmembrane domain vaccination Vaccine Vaccine development viral respiratory Virus neutralization [DOI] 10.1016/j.virusres.2016.07.010 PMC 바로가기 [Article Type] Article
Measles Virus Fusion Protein: Structure, Function and InhibitionReview Published on 2016-04-212023-08-29 Journal: Viruses [Category] E형 간염, [키워드] cell entry fusion protein inhibitors and mechanisms of adaptation measles virus membrane fusion neuroinvasion structural changes [DOI] 10.3390/v8040112 PMC 바로가기 [Article Type] Review
Design, structure prediction and molecular dynamics simulation of a fusion construct containing malaria pre-erythrocytic vaccine candidate, Pf CelTOS, and human interleukin 2 as adjuvant말라리아 적혈구 전 백신 후보인 Pf CelTOS 및 인간 인터루킨 2를 보조제로 포함하는 융합 구조물의 설계, 구조 예측 및 분자 역학 시뮬레이션Research Article Published on 2016-02-062024-07-27 Journal: BMC Bioinformatics [Category] 말라리아, [키워드] fusion protein malaria molecular dynamics simulations Molecular modeling [DOI] 10.1186/s12859-016-0918-8 PMC 바로가기 [Article Type] Research Article
A novel plant-produced Pfs25 fusion subunit vaccine induces long-lasting transmission blocking antibody responsesarticle Published on 2015-12-312024-09-01 Journal: Human vaccines & immunotherapeutics [Category] 말라리아, [키워드] fusion protein lichenase malaria Pfs25 plant-produced antigen Plasmodium falciparum Subunit vaccine Transmission blocking vaccine [Article Type] article
Genetic conjugation of components in two pneumococcal fusion protein vaccines enhances paediatric mucosal immune responses두 폐렴구균 융합 단백질 백신의 구성 요소의 유전적 접합은 소아 점막 면역 반응을 강화합니다.journal-article Published on 2015-03-012024-08-04 Journal: Vaccine [Category] 폐렴구균 감염증, [키워드] CD4+ T-cell fusion protein mucosal immunity paediatric Streptococcus pneumoniae [DOI] 10.1016/j.vaccine.2015.02.012 [Article Type] journal-article
Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent MannerResearch Article Published on 2014-11-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Cell cell entry Clathrin-mediated endocytosis cleavage conformational change coronavirus CoV CoVs demonstrated endocytosed endosomal maturation endosomal pH entry pathway expressing furin furin cleavage site fusion fusion peptide fusion protein gene silencing Genome Host host cell host cell membrane induce Infection influenza A virus inhibited introduced investigated late endosomes less lysosomal protease lysosomal proteases lysosome membrane fusion MERS MERS-CoV MHV microenvironment mouse hepatitis murine hepatitis virus negatively affected occur pathogen plasma membrane predicted previous study promote protease Protease inhibitor Protein proteolytic cleavage Proteolytic processing reporter required S protein shown siRNA Specific the S protein upstream vesicular stomatitis virus virus while zoonotic [DOI] 10.1371/journal.ppat.1004502 PMC 바로가기 [Article Type] Research Article
Molecular Characterizations of Subcellular Localization Signals in the Nucleocapsid Protein of Porcine Epidemic Diarrhea VirusArticle Published on 2014-03-132022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Amino acid antibiotic Cell cellular characterization chromosome CHROMOSOME region maintenance 1 confocal microscopy coronavirus Critical cytoplasm epidemic diarrhea eukaryotic fluorescent full-length functional fusion protein GFP Infection inhibited Localization Mutation N protein NES nuclear nuclear export signal nucleocapsid nucleocapsid protein Nucleolus pathway PEDV Porcine epidemic diarrhea virus Protein signal site-directed mutagenesis subcellular localization signals the N protein VERO E6 cells virus virus replication [DOI] 10.3390/v6031253 PMC 바로가기 [Article Type] Article
Single injection recombinant vesicular stomatitis virus vaccines protect ferrets against lethal Nipah virus diseaseResearch Published on 2013-12-132023-08-29 Journal: Virology Journal [Category] E형 간염, [키워드] attachment protein ferret fusion protein glycoprotein henipavirus Immunity Nipah virus Single-injection Vaccine vesicular stomatitis virus [DOI] 10.1186/1743-422X-10-353 PMC 바로가기 [Article Type] Research
Identification of a conserved linear B-cell epitope in the M protein of porcine epidemic diarrhea virusResearch Published on 2012-10-012022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Amino acid Analysis Antigen antigenic B-cell epitope C-terminus cell line conserved Coronaviruses demonstrated diagnostic different elicit ELISA enzyme-linked immunosorbent epidemic diarrhea epitope epitope-based vaccines fusion protein gastroenteritis GST identification information linear M protein membrane monoclonal antibody motif overlapping PEDV protective antibodies Protein provide reactivity Result secreting sequence serum shown Strains virus was obtained were expressed western blot [DOI] 10.1186/1743-422X-9-225 PMC 바로가기 [Article Type] Research