Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations3067 SARS-CoV-2 게놈의 대규모 게놈 분석을 통해 핫스팟 돌연변이의 클론 지리 분포와 풍부한 유전적 변이가 밝혀졌습니다.Research Article Published on 2020-11-102022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, [키워드] accumulation Affect allele Analysis analyzed characterization China collected Comparative genomics country COVID-19 database distribution Evolution frequencies Frequency Genetic variant genetic variants Genetic variation Genomic analysis Genotype geographic location geographic locations global pandemic haplotypes hotspot mechanism mutated Mutation mutations Non-synonymous Non-synonymous mutation phylogeographic analysis Prevalence profile profiles recurrent mutation residue resulting reveal SARS-CoV-2 SARS-CoV-2 genes SARS-CoV-2 genome SARS-CoV-2 genomes selected selective severity shown Spread the epidemic the SARS-CoV-2 the SARS-CoV-2 genome therapeutic targets variant Viral viral infection virus whole-genome Wuhan Wuhan, China [DOI] 10.1371/journal.pone.0240345 PMC 바로가기 [Article Type] Research Article
Threading the Pieces Together: Integrative Perspective on SARS-CoV-2Review Published on 2020-11-042022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome approach Asymptomatic individuals Clinical data Clinical outcome clinical symptom Co-infection Community comorbid condition Comorbidities Comorbidity coronavirus COVID-19 COVID-19 pandemic domain drugs effort facilitate genetic variants heterogeneity host response include Infection information integrative genomics metagenome microbial modulated Mortality outcome pandemic phenotype piece predisposition produced Protective pursuit Research researcher SARS-CoV-2 SARS-CoV-2 genome symptomatic symptomatic individuals Therapeutics Transcriptome Vaccines variables [DOI] 10.3390/pathogens9110912 PMC 바로가기 [Article Type] Review
A Novel Coronavirus Disease (COVID-19): a Review of Host Cell Signaling PathwaysReview Article Published on 2020-11-012022-10-28 Journal: Tanaffos [Category] COVID-19, [키워드] acute respiratory syndrome caused changes in coronavirus coronavirus disease CoV COVID-19 CoVs develop evaluate genetic variants Health Healthcare system Host host cell host cell factor host-pathogen interaction host-pathogen interactions Inflammation innate immune system Interaction lung Lung inflammation molecular novel pandemic persistence physician positive-sense progression proliferation promote recognize reduce review risk RNA viruses SARS-CoV-2 signaling pathway signaling pathways targeted therapy PMC 바로가기 [Article Type] Review Article
Androgen sensitivity gateway to COVID-19 disease severityCOVID-19 질병 중증도에 대한 안드로겐 민감성 관문Article Published on 2020-11-012022-09-11 Journal: Drug development research [Category] SARS, 변종, 유전자 메커니즘, [키워드] activating addition alopecia androgen Androgen receptor androgens Anti-androgen benign prostatic hyperplasia Cell fusion children clinical trial COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 mortality determined by develop epidemiological Evidence explain Genetic variant genetic variants hospitalized COVID-19 patient hospitalized COVID-19 patients host susceptibility Infection male molecular mechanisms Neutralizing antibodies neutralizing antibody pandemic polycystic ovary Prostate cancer protease Protein receptor regulate required SARS-CoV-2 sensitivity Serine serine 2 severe symptom severe symptoms Spike protein syndrome the Spike TMPRSS2 Transcription transmembrane Trial variant Viral virus [DOI] 10.1002/ddr.21688 PMC 바로가기 [Article Type] Article
Tissue Proteases and Immune Responses: Influencing Factors of COVID-19 Severity and MortalityReview Published on 2020-10-062022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome Affect affected age agency Asthma caused Characteristics confirmed cases contribute coronavirus coronavirus disease COVID-19 Critically ill current develop diabetes disease outcome disease severity expression level Factor genetic variants Host host factors hypertension immune response immune responses incidence individual intrinsic Medical conditions Mortality outcome populations profile protease Proteins question reported SARS-CoV-2 severe disease Stage suggested Surveillance susceptibility the disease those with comorbidity tissue tissue proteases [DOI] 10.3390/pathogens9100817 PMC 바로가기 [Article Type] Review
Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population AnalysisSARS-CoV-2와 잠재적으로 관련된 숙주 유전 변이: 다중 집단 분석Genetics Published on 2020-10-022022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect African AHSG alleles allelic Analysis Asian association average calculate caused CCL2 CCL5 CD209 clinical collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease distribution EAS eQTLs European Europeans expression expression data expression quantitative trait loci Frequency furin genetic determinant genetic determinants Genetic polymorphism genetic polymorphisms genetic variants genetics Genome GWAS highlight host genetics ICAM3 identify IFN IL4 inter-individual list loci lowest modulate Multiple nucleotide outcome outcomes Population genetics populations predict promoter Quantitative respiratory Result risk risk allele SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility sequence sequences severe acute respiratory syndrome Coronavirus severity significantly significantly lower Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility TMPRSS2 variant viruses were used [DOI] 10.3389/fgene.2020.578523 PMC 바로가기 [Article Type] Genetics
CoV-Seq, a New Tool for SARS-CoV-2 Genome Analysis and Visualization: Development and Usability StudyOriginal Paper Published on 2020-10-022022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] addition Analysis automatically bioinformatics Biotechnology center China National GeneBank CNGB COVID-19 data sets database development downstream analysis ENA European Nucleotide Archive Genetic Genetic variant genetic variants genetics Genome genome analysis GISAID global pandemic help identify IMPROVE initiative interactive module knowledge labor-intensive NCBI New objective predict programming provide provided Result SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 sequence SARS-CoV-2 sequences sequence sequenced Usability virus web server [DOI] 10.2196/22299 PMC 바로가기 [Article Type] Original Paper
Genetic variants and source of introduction of SARS-CoV-2 in South America남미에서 SARS-CoV-2의 유전적 변이와 도입원Article Published on 2020-10-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 유전자 메커니즘, [키워드] alteration Asian changes in Chilean Complete contribute COVID-19 demonstrated domain Europe followed by Genetic genetic variants Genome genomic information GISAID database globe hotspot introduced isolate isolates MOST Mutation Oceania Pandemics Phylogeny S protein SARS-CoV-2 South South America strain Strains the S protein variant variants Viral viral evolution viral genome viral genomes viral replication virus viruses [DOI] 10.1002/jmv.26001 PMC 바로가기 [Article Type] Article
Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of OutcomeACE2 변이의 스펙트럼 분석은 COVID-19에 대한 감수성과 결과의 심각성에 대한 희귀 및 공통 변이의 가능한 영향을 시사합니다Genetics Published on 2020-09-292022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] ACE2 ACE2 variant ACE2 variants acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect allele frequency alternative allele analyzed angiotensin angiotensin-converting enzyme-2 caused Cohort common coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dataset disease severity eQTL European population European populations explain frequencies Frequency Genetic variant genetic variants Genome Aggregation Database gnomAD gnomAD database Health Organization influence Missense missense variant mutations objective outcome pandemic Patient patients with COVID-19 Regulatory respiratory Respiratory disease Result rs146598386 rs73195521 rs755766792 Russia Russian population severity Severity of disease Southern European population Spectrum statistical Support susceptibility variant variants whole-exome sequencing World Health Organization [DOI] 10.3389/fgene.2020.551220 PMC 바로가기 [Article Type] Genetics
Genetic Spectrum and Distinct Evolution Patterns of SARS-CoV-2Microbiology Published on 2020-09-252022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Clustering Co-infection Complete coronavirus country COVID-19 Evolution exhibited Genetic genetic variants Genome Genome sequences group homogenous Host Mutation nucleotide substitution occurred Patient pattern RaTG13 Recombination representing SARS-CoV-2 SARS-CoV-2 genome sequence single-nucleotide SNV SNVs Spectrum Tolerance variant viral strain viral strains Wuhan-Hu-1 [DOI] 10.3389/fmicb.2020.593548 PMC 바로가기 [Article Type] Microbiology