Comparative sequence analysis of SARS-CoV-2 suggests its high transmissibility and pathogenicityResearch Article Published on 2021-03-082022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] adaptive Analysis analyzed bat-SL-CoV Comparative CoV COVID-19 Deletion disease severity Evolution feature furin-like cleavage site Genome highly pathogenic humans introduced material Multiple sequence alignment Mutation ORF1a/b ORF3a ORF3b ORF8 Pathogenesis pathogenicity Protein protein sequence Proteins SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike Sequence analysis Spike protein Transmissibility unique [DOI] 10.2217/fvl-2020-0204 PMC 바로가기 [Article Type] Research Article
Clinical and molecular aspects of veterinary coronavirusesReview Published on 2021-03-082022-11-01 Journal: Virus research [Category] COVID-19, 조류인플루엔자, [키워드] Characteristics clinical Clinical sign Clinical signs coronavirus Coronavirus infection Coronaviruses Cross-species transmission diagnosed disease Diseases event highly pathogenic Host Human infect knowledge Middle East Modification molecular molecular basis Mutation New coronavirus one health ORFs Pathogenesis plasticity Prevent promote public health receptor Recombination Replication respiratory RNA virus SARS-CoV-2 spreads turn veterinary medicine [DOI] 10.1016/j.virusres.2021.198382 PMC 바로가기 [Article Type] Review
Exploring G protein-coupled receptors and yeast surface display strategies for viral detection in baker’s yeast: SARS-CoV-2 as a case study빵 효모에서 바이러스 검출을 위한 G 단백질 결합 수용체 및 효모 표면 디스플레이 전략 탐색: 사례 연구로서의 SARS-CoV-2Review Published on 2021-03-042022-09-11 Journal: FEMS yeast research [Category] SARS, 진단, 치료기술, [키워드] ACE2 activated angiotensin Angiotensin-converting enzyme antibody biosensor case study cell receptor complex complexity components Concentration coronavirus COVID-19 Diagnosis diagnosis of COVID-19 diagnostics display effective enrolled enzyme example G protein G protein-coupled receptor G protein-coupled receptors Healthcare system Healthcare systems highly pathogenic Infection Interaction methodology microorganism modulated physical platform receptors Saccharomyces cerevisiae SARS-CoV-2 surface Synthetic biology Treatment Viral Viral detection viral disease Viral diseases viral infections viral titer virus detection viruses while yeast yeast surface display. [DOI] 10.1093/femsyr/foab004 PMC 바로가기 [Article Type] Review
Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal InfectionResearch Article Published on 2021-03-022022-10-29 Journal: mBio [Category] COVID-19, [키워드] acute respiratory syndrome approved attenuate attenuated vaccine C-terminal domain Cell culture coronavirus coronavirus SARS-CoV-2 Coronaviruses Deletion described dose E protein genetics genome engineering highly pathogenic immune responses immunization indicate induce Interaction killing knowledge lethal life-threatening long-lasting MERS-CoV Middle East mutant mutants passage Pathogenesis protection Protein provided Research respiratory respiratory syndrome coronavirus Safe SARS-CoV selected signaling pathway Vaccine vaccine candidate Vaccines virulence virulent virus virus replication [DOI] 10.1128/mBio.00103-21 PMC 바로가기 [Article Type] Research Article
Coronavirus biology and replication: implications for SARS-CoV-2코로나바이러스 생물학 및 복제: SARS-CoV-2에 대한 의미Review Published on 2021-03-012022-09-11 Journal: Nature reviews. Microbiology [Category] Coronavirus, SARS, 유전자 메커니즘, 치료제, [키워드] antiviral intervention Awareness cellular mechanism clinically coronavirus coronavirus biology Coronavirus infections coronavirus SARS-CoV Critical determinant effective intervention Efficacy Epidemics highlight highly pathogenic Host human population identify implication knowledge life cycle MERS-CoV molecular other coronavirus other coronaviruses preventive interventions raised review SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic severe disease similarities similarity Support target targets therapeutic Treatment viral life cycle Virus-host interaction Virus-host interactions Zoonotic introduction [DOI] 10.1038/s41579-020-00468-6 PMC 바로가기 [Article Type] Review
Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system1차 인간 기도 시스템에서 합성 STING 효능제에 의한 코로나바이러스 감염 억제Article Published on 2021-03-012022-09-11 Journal: Antiviral Research [Category] SARS, 유전자 메커니즘, 치료제, [키워드] 229E Activation addition agonists Air-liquid interface airway anti-coronavirus activity antiviral activity apical surface approved autophagy caused cell culture systems clinically common cold coronavirus Coronavirus infection Coronavirus infections COVID-19 cultures Defense defense mechanisms demonstrated dependent on diABZI. dimeric effective elicit epithelial fibroblast HCoV HCoV-229E highly pathogenic Host host defense human coronavirus human coronavirus 229E human coronaviruses Infection inhibition inhibitory effect initiated interferon interferon pathway International investigated low-dose lung cell mechanism Medicine microbial microbial infections other coronavirus other coronaviruses outbreak Pathogens pathway Pneumonia Prevent prevented primary human airway public health emergency receptor reduced Remdesivir responses SARS-CoV-2 SARS-CoV-2 viral load SARS-CoV-2 virus small molecule Spread stimulator STING STING agonist the interferon the SARS-CoV-2 therapeutic potential treat Treatment triggered type I interferon unmet need Viral load [DOI] 10.1016/j.antiviral.2021.105015 PMC 바로가기 [Article Type] Article
COVID-19 in Farm Animals: Host Susceptibility and Prevention StrategiesReview Published on 2021-02-282022-10-28 Journal: Animals : an Open Access Journal from MDPI [Category] COVID-19, [키워드] affected African animals biosecurity measures caused Contact Coronaviridae coronavirus COVID-19 COVID-19 infection demonstrated effective farm highly pathogenic Human Impact Influenza measure mechanism outbreak pandemic disease prevention reported SARS-CoV-2 simple Spread Strategy Transmission vaccination Vaccine virus zoonotic [DOI] 10.3390/ani11030640 PMC 바로가기 [Article Type] Review
The Role of the Host Ubiquitin System in Promoting Replication of Emergent VirusesReview Published on 2021-02-262022-10-28 Journal: Viruses [Category] COVID-19, [키워드] acute respiratory syndrome antagonism of immune response Antiviral broad-spectrum antivirals can be used cellular conserved coronavirus Defense develop Ebola emergent viruses ENhance evade function functions highly pathogenic Host immune immune responses mechanism Nipah pathogen Pathogenesis post-translational modification pro-viral function Promoting Protein protein stability Replication role SARS-CoV-2 Signaling System tripartite motif (TRIM) proteins ubiquitin ubiquitin system Viral protein virus virus entry virus replication viruses while Zika [DOI] 10.3390/v13030369 PMC 바로가기 [Article Type] Review
Endothelial Cells in Emerging Viral InfectionsCardiovascular Medicine Published on 2021-02-242022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] appear bystander Comorbidity component COVID-19 detect Deterioration detrimental diabetes disease dissemination dysregulated emerging infections Endothelial cell endothelial cells Endothelial dysfunction endothelial function Endothelium exacerbate facilitate feature functions Health highlight highly pathogenic host immune system hypertension immune response immune responses in viral infect Infection Inflammation Inflammatory Influenza virus life-threatening mechanism modulate obesity pathway regulate replicate respond SARS-CoV-2 second Severe case severe COVID-19 Support tissues Validity Vascular vascular dysfunction and damage vascular endothelial cell Vascular function Viral diseases viral infections virulence virus viruses [DOI] 10.3389/fcvm.2021.619690 PMC 바로가기 [Article Type] Cardiovascular Medicine
The analysis on the human protein domain targets and host-like interacting motifs for the MERS-CoV and SARS-CoV/CoV-2 infers the molecular mimicry of coronavirusResearch Article Published on 2021-02-172022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] Analysis biological process biological processe carbon source coronavirus Coronavirus infection develop disease DMI domain effective enrichment expression help highly pathogenic host cells human protein humans information Interaction mapped mechanism Medicine MERS-CoV molecular MOST motif Ontology potassium channel Protein protein domain proteomes Regulation SARS-CoV SARS-CoV-2 T cell epitopes target Therapies Treatment Viral protein virus viruses was performed [DOI] 10.1371/journal.pone.0246901 PMC 바로가기 [Article Type] Research Article