Vaccine effectiveness of primary series and booster doses against covid-19 associated hospital admissions in the United States: living test negative design studyArticle Published on 2022-10-112022-11-16 Journal: The BMJ [Category] COVID19(2023년), SARS, 변종, [키워드] 95% confidence interval acute respiratory symptom Analysis benefit BNT162b2 booster booster dose case-control study controls dominant Effectiveness evaluated Evidence hospital Hospital admission Immunocompromised Immunocompromised patients Immunosuppression interquartile range laboratory confirmed covid-19 median age mRNA vaccine mRNA-1273 occur Omicron variant outcome participant Participants Patient primary analysis provided regimen SARS-CoV-2 secondary analysis stratified test negative tested The United States Vaccine [DOI] 10.1136/bmj-2022-072065 PMC 바로가기
Methicillin-resistant staphylococcus aureus nosocomial infection has a distinct epidemiological position and acts as a marker for overall hospital-acquired infection trendsArticle Published on 2022-10-112022-11-15 Journal: Scientific Reports [Category] 바이오마커, [키워드] Analysis Biomarker Care Control COVID-19 pandemic dataset disease Diseases drug-resistant Efficacy epidemiological epidemiologist HAI healthcare hospital hospitalized patients Infection lack Lower marker microbe MRSA Nosocomial infection Nosocomial infections outbreak pathogen Patient prevented reduced replaced Staphylococcus aureus Stress threshold unique USA [DOI] 10.1038/s41598-022-21300-6 PMC 바로가기
Central and effector memory T cells in peripheral blood of patients with interstitial pneumonia: preliminary clues from a COVID-19 studyArticle Published on 2022-10-102022-11-15 Journal: Respiratory Research [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute phase addition affected Analysis biological marker CD3+ cells CD4 CD8 Cell cell population central memory Central memory T cells control group control patient controls COVID-19 COVID-19 diagnosis cross-sectional decrease described differential expression disease early phase effector effector memory Effector memory T cells flow cytometry group homeostasis hospital Hospital admission immune increase interstitial interstitial lung involvement interstitial pneumonia lymphocyte subpopulation Lymphocyte subpopulations memory memory T memory T cells Patient patients with pneumonia performed Peripheral blood peripheral lymphocyte Pneumonia positive pre-existing T-cell protocol reactivity recruited Research Respiratory disease SARS-CoV-2 SARS-CoV-2 PCR severe COVID-19 patients significant decrease significant increase study participant study period subpopulations subset T cell T-cell therapeutic viral respiratory infections were assessed [DOI] 10.1186/s12931-022-02190-8 PMC 바로가기
An explanatory model of depressive symptoms from anxiety, post-traumatic stress, somatic symptoms, and symptom perception: the potential role of inflammatory markers in hospitalized COVID-19 patientsArticle Published on 2022-10-102022-11-15 Journal: BMC Psychiatry [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Analysis Anxiety anxiety symptom anxiety symptoms association back pain biological marker collected conducted COVID-19 COVID-19 pandemic cross-sectional demonstrated Depression depressive depressive symptom Depressive symptoms evaluate explain Factor highest hospital Hospitalized hospitalized COVID-19 patient hospitalized patient hypothese identify incidence individual Inflammation Inflammatory Inflammatory marker inflammatory markers Inflammatory response influence irritability marker mental health mental health problem NLR performed Peru post-traumatic Post-traumatic stress Post-traumatic stress symptoms predict Predictive Prevalence problem Psychological random Result Stress Symptom Symptoms variable vulnerable patient with COVID-19 [DOI] 10.1186/s12888-022-04277-4 PMC 바로가기
Development of a low-cost multi-channel nucleic acid detection PCR instrument and clinical detection application of COVID-19Article Published on 2022-10-092022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] amplification COVID-19 COVID-19 outbreak development disadvantage Double channel experiment hospital Low-cost novel Novel coronavirus Nucleic acid detection optical PCR Quantitative quantitative PCR quantitative PCR instrument Real-time fluorescence quantitative PCR. variety were used [DOI] 10.1016/j.aca.2022.340338 PMC 바로가기
Respiratory Virus Surveillance Among Children with Acute Respiratory Illnesses – New Vaccine Surveillance Network, United States, 2016-2021Article Published on 2022-10-072022-11-15 Journal: Morbidity and Mortality Weekly Report [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] accounted acute respiratory illness Adenovirus Analysis antibody-based prophylactics anticipated ARI Atypical calculate Care cause caused children circulation Clinical data clinics Community COVID-19 COVID-19 vaccine current demographic characteristics described Effectiveness eligible enrolled Enrollment estimate Health highlighting hospital Hospitalized Human rhinovirus implementation incidence Infant Infants Influenza Influenza virus Measures medical condition métapneumovirus monoclonal morbidity network New nonpharmaceutical intervention pandemic parainfluenza pathogen pathogen-specific pediatric platform proportion PROTECT respiratory respiratory syncytial virus respiratory virus risk factor RSV SARS-CoV-2 Seven severe disease Surveillance United States vaccination Vaccine virus [DOI] 10.15585/mmwr.mm7140a1 PMC 바로가기
Imbalanced Angiogenesis in Pregnancies Complicated by SARS-CoV-2 InfectionArticle Published on 2022-10-072022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Admission age angiogenic factors antithrombotic therapy Asymptomatic asymptomatic patient clinically collected COVID-19 cut-off value death diagnosed Diagnosis diagnosis of SARS-CoV-2 dysfunction dysregulation endothelial Endothelial dysfunction evaluate Factors FGR gestation growth factor hospital incidence Infection intensive care management marker mother Neonatal Neonate not significantly different Patient placental placental dysfunction preeclampsia Pregnancy pregnant population pregnant women proportion RAS reported resulting Retrospective analysis SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positive asymptomatic Serum level severity sFlt-1 Stillbirth stratified Symptom symptomatic symptomatic patient symptoms of COVID-19 turn tyrosine was performed with COVID-19 women [DOI] 10.3390/v14102207 PMC 바로가기
Limited value of neutrophil-to-lymphocyte ratio and serum creatinine as point-of-care biomarkers of disease severity and infection mortality in patients hospitalized with COVID-19Article Published on 2022-10-062022-11-15 Journal: PLoS ONE [Category] 바이오마커, [키워드] 95%CI Accuracy adjusted analyzed AOR association assumption Biomarker cohort study COVID-19 COVID-19 patient creatinine cut-off death disease severity elevated enrolled hospital hospitalized COVID-19 Infection IQR Limited males median age monitoring Mortality Neutrophil-to-lymphocyte ratio NLR non-survivor Odds ratio outcome Patient patients hospitalized point-of-care predict predictor Prognosis Prognostic marker progression Prospective receiver operating characteristics Sensitivity and specificity serum creatinine Severe case severity significantly significantly higher Still survivor the disease Treatment with COVID-19 [DOI] 10.1371/journal.pone.0275391 PMC 바로가기
Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregatesArticle Published on 2022-10-052022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] absence activated Activation aggregate aggregates analysed antiviral immunity Blood blood cell CD107a CD62P Cell cells changes in chemokines Cohort correlated COVID-19 COVID-19 disease COVID-19 patient cytokine Cytokines Cytometry cytotoxicity discharged disease pathology early stage Ex vivo Features flow cytometry form Frequency gene signature hospital hospitalised hospitalised COVID-19 patient ICU ICU patient IFN-γ IL-15 in vitro increased expression Infection innate immune response intensive care unit killing majority natural Neutrophils NK cell NK cells Patient patients phenotype phenotyped plasma Platelet platelet aggregates. Platelets Post-COVID-19 patients quantified SARS-CoV-2 scRNA-seq severe COVID-19 disease severe symptoms Single-cell RNA-sequencing Stage subset Symptom Symptoms target cells the timing TNF-α viral infections were measured while [DOI] 10.3389/fimmu.2022.861251 PMC 바로가기
Real-world effectiveness of steroids in severe COVID-19: a retrospective cohort studyArticle Published on 2022-10-052022-11-16 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] age analysed association clinical co-morbidity Cohort confounder Controlled trial Coronavirus disease 2019 COVID-19 defined Dexamethasone disease Effectiveness EPR Gender hazard hospital Hydrocortisone hypoxia in-hospital mortality individual Methylprednisolone Mortality multivariable multivariate model outcome Patient positive patient Prednisolone protective effect randomised clinical trial reduce replicate replicated reported retrospective cohort study Retrospective study risk SARS-CoV-2 RNA SARS-CoV-2 variant severe COVID-19 shown steroid steroid treatment Steroids treated Treatment viral genome was measured [DOI] 10.1186/s12879-022-07750-3 PMC 바로가기