Results of the CAPSID randomized trial for high-dose convalescent plasma in patients with severe COVID-19중증 COVID-19 환자의 고용량 회복기 혈장에 대한 CAPSID 무작위 시험 결과Randomized Controlled Trial Published on 2021-10-152022-09-12 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 임상, 진단, [키워드] 1:1 added benefit CCP clinical Clinical improvement clinical trials Control control group convalescent plasma COVID-19 criteria cross cumulative discharge Efficacy High-dose hospital hospital discharge Hospitalized immunoglobulins intensive care interval median time Neutralizing Neutralizing antibodies neutralizing antibody occurred outcome Patient Primary outcome probability of survival Randomized randomized trial receive Respiratory Support Result Secondary outcomes severe COVID-19 significantly shorter standard treatment standard treatment alone subgroup analysis survival the patient Treatment Trial with COVID-19 [DOI] 10.1172/JCI152264 PMC 바로가기 [Article Type] Randomized Controlled Trial
Response to BNT162b2 mRNA COVID-19 vaccine among healthcare workers in Italy: a 3-month follow-up이탈리아 의료 종사자들의 BNT162b2 mRNA COVID-19 백신에 대한 반응: 3개월 추적 관찰Im - Original Published on 2021-10-122022-09-10 Journal: Internal and Emergency Medicine [Category] MERS, SARS, 치료기술, [키워드] administration Adverse adverse events anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody BNT162b2 BNT162b2 mRNA BNT162b2 vaccine COVID-19 COVID-19 vaccine cut-off Effectiveness event exceeded first dose focus Follow-up HCW HCWs healthcare worker Healthcare workers high risk hospital immunization immunoglobulins Infection investigated Italian Nasopharyngeal swab nasopharyngeal swabs nucleic acid offer participant Participants positive reactivity recipients reported Research response RT-PCR assay SARS-CoV-2 SARS-CoV-2 nucleic acid serology testing tested the vaccine Vaccine vaccine response [DOI] 10.1007/s11739-021-02857-y PMC 바로가기 [Article Type] Im - Original
COVID-19 in pediatric cancer patients is associated with treatment interruptions but not with short-term mortality: a Polish national study소아암 환자의 COVID-19는 치료 중단과 관련이 있지만 단기 사망과는 관련이 없습니다: 폴란드 국가 연구Research Published on 2021-10-112022-09-10 Journal: Journal of Hematology & Oncology [Category] MERS, SARS, 치료제, [키워드] 95% CI absolute neutrophil count acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration Adults analyzed Antibiotic therapy Asymptomatic cancer patient Cancer patients Cancer therapy caused Chemotherapy chemotherapy cycle children collected completion convalescent convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 correlated coryza cough Course COVID-19 COVID-19 infection death Delay diagnosed Diagnosis Fever Gastrointestinal symptom gastrointestinal symptoms headache Health hematological heparin immunoglobulins increase Intravenous immunoglobulin Isolation life-threatening majority malignancies malignancy material median median time Mortality National neutrophil occurred oncology oxygen Oxygen therapy Patient patients PCR positivity pediatric positive positive PCR positive PCR result Probability Record Remdesivir respiratory respiratory symptoms Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 testing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 steroid Steroids study population supplementary material survival Symptom symptomatic Symptoms the median therapy treated Treatment undergo Ventilation Viral was performed were recorded with COVID-19 [DOI] 10.1186/s13045-021-01181-4 PMC 바로가기 [Article Type] Research
Intravenous immunoglobulins for the treatment of the hyper-inflammatory response in COVID-19. Another failure of immunomodulatory therapy?COVID-19의 과염증 반응 치료를 위한 정맥 면역글로불린. 면역 조절 요법의 또 다른 실패?Article Published on 2021-10-012022-09-12 Journal: Clinical microbiology and infection : the official [Category] MERS, 진단, [키워드] Abstract COVID-19 hyper-inflammatory response Immunoglobulin immunoglobulins immunomodulation immunomodulatory SARS-CoV-2 Treatment [DOI] 10.1016/j.cmi.2021.07.012 PMC 바로가기 [Article Type] Article
Therapeutic Approaches in Modulating the Inflammatory and Immunological Response in Patients With Sepsis, Acute Respiratory Distress Syndrome, and Pancreatitis: An Expert Opinion ReviewGastroenterology Published on 2021-09-302022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory distress Alpha Alter approach ARDS Clinical outcome conditions COVID-19 COVID-19 patients Critically ill Critically ill patient expert greater help immune response immunoglobulins immunomodulation immunomodulator immunomodulators Immunopathogenesis IMPROVE intravenous majority novel coronavirus disease opinion organ dysfunction outcome pandemic Pathogenesis Patient physician respiratory response review Sepsis serine protease inhibitor Shock shown steroid Steroids syndrome the cytokine storm Therapeutic plasma exchange therapy Ulinastatin [DOI] 10.7759/cureus.18393 PMC 바로가기 [Article Type] Gastroenterology
Monitoring Specific IgM and IgG Production Among Severe COVID-19 Patients Using Qualitative and Quantitative Immunodiagnostic Assays: A Retrospective Cohort Study정성적 및 정량적 면역진단 분석을 사용하여 중증 COVID-19 환자 중 특정 IgM 및 IgG 생산 모니터링: 후향적 코호트 연구Immunology Published on 2021-09-032022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, 치료법, [키워드] Abbott acute respiratory syndrome analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody production Architect assays association Cohen’s kappa coefficient Combination Concentration concentrations confirmed COVID-19 patients coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient develop Diagnosis early phase form humoral immune response IgG IgG and IgM IgG test IgM IgM and IgG IgM antibody IgM seroconversion immunoassays immunoglobulins MONITOR monitoring Mortality Patient Pearson correlation coefficient performed positive positive relationship processed Production Qualitative Quantitative respiratory robust SARS-CoV-2 SARS-CoV-2 IgG Saudi Arabia sera seroconversion rate seroconversion rates Serological testing serum severe severe COVID-19 severity of COVID-19 Specific test results tested [DOI] 10.3389/fimmu.2021.705441 PMC 바로가기 [Article Type] Immunology
Delayed presentation of postinfectious encephalitis associated with SARS-CoV-2 infection: a case reportSARS-CoV-2 감염과 관련된 감염 후 뇌염의 지연된 발표: 증례 보고Case Reports Published on 2021-09-012022-09-11 Journal: Neurological Sciences [Category] SARS, 치료기술, [키워드] Brain Case report cerebrospinal fluid clinical suspicion complete recovery Corticosteroid Corticosteroids COVID-19 Delayed Diagnosis electroencephalogram Encephalitis feature High-dose IgM antibodies IgM antibody immune Immune-mediated immunoglobulins Immunotherapy increasingly Infection initial intravenous magnetic resonance imaging manifestation mechanisms neurological manifestations outcome Patient Postinfectious postinfectious encephalitis presenting pulmonary disease SARS-CoV-2 SARS-CoV-2-specific antibody SARS-CoV-2-specific IgG specific antibodies status epilepticus Treatment viral invasion [DOI] 10.1007/s10072-021-05395-9 PMC 바로가기 [Article Type] Case Reports
Stability of SARS-CoV-2 IgG in multiple laboratory conditions and blood sample types여러 실험실 조건 및 혈액 샘플 유형에서 SARS-CoV-2 IgG의 안정성Article Published on 2021-09-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 진단, 치료기술, 치료법, [키워드] antibody Antibody detection Architect assays Beijing blood sample cassettes collected condition conditions COVID-19 demonstrated detect Elecsy ELISA ELISAs evaluated Freeze-thaw cycle Genscript heparin IgG IgG response IgM IgM antibodies IgM antibody Immunoglobulin immunoglobulins individuals Laboratory less lithium Lithium heparin manual material neutralization Neutralization assay nucleocapsid plasma plasma sample plasma samples positive Rapid test rapid test cassette Roche Sample SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SD Biosensor seropositive individual seropositive individuals serum serum/plasma specimen stability storage Test [DOI] 10.1016/j.jcv.2021.104933 PMC 바로가기 [Article Type] Article
Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Leukoencephalitis Following COVID-19: Systematic Review and Meta-synthesisCOVID-19에 따른 급성 파종성 뇌척수염 및 급성 출혈성 백질뇌염: 체계적인 검토 및 메타 합성Article Published on 2021-08-272022-09-12 Journal: Neurology® neuroimmunology & neuroinflammation [Category] MERS, SARS, 진단, [키워드] age analyzed approach Brain Case report Clinical features Clinical outcome CNS complete case analysis country COVID-19 infection COVID-19 pandemic CSF described Diagnosis died disease Encephalomyelitis Final finding Follow-up hemorrhage Hemorrhagic Leukoencephalitis high mortality rate hospital immunoglobulins immunomodulatory Infection infection with COVID-19 information intensive care Laboratory Leukoencephalitis median median age men MRI neurologic occurred Occurrence outcomes Patient presenting provided radiographic abnormalities relapsing reported response to treatments review scale severity Steroids systematic review tested vaccination against COVID-19 variable were excluded were used [DOI] 10.1212/NXI.0000000000001080 PMC 바로가기 [Article Type] Article
Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assayResource and Technical Advance Published on 2021-08-232022-10-30 Journal: JCI Insight [Category] COVID-19, SARS, [키워드] ACE2 receptor ACE2-RBD Angiotensin-converting enzyme antibody Antibody therapeutics binding domain candidate complementary COVID-19 domains Effectiveness facilitate functional Immune escape immune escape mutations immunoglobulins inhibit SARS-CoV-2 inhibitory monoclonal antibody Multiplex assay N439K N501Y natural infection neutralizing antibody neutralizing capacity RBD RBD variant S477N SARS-CoV-2 receptor SARS-CoV-2 research serological Simultaneous Surveillance the SARS-CoV-2 vaccination Vaccine variant [DOI] 10.1172/jci.insight.150012 PMC 바로가기 [Article Type] Resource and Technical Advance