Immunopathogenesis of Different Emerging Viral Infections: Evasion, Fatal Mechanism, and PreventionImmunology Published on 2021-07-152022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Antibody-dependent enhancement Clarification COVID-19 Dengue diagnose early diagnosis early treatment emerging viral infections evasion fatality global pandemic hyperinflammation Immunity Immunopathogenesis immunopathology Infection infections management mechanism microbial morbidity and mortality Mutation Perspective Prevent prevention provided reduce reduction Region Transmission viral infection Viral load Viremia Virus neutralization zoonotic [DOI] 10.3389/fimmu.2021.690976 PMC 바로가기 [Article Type] Immunology
COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomesCOVID-19 가상 환자 코호트는 질병 결과를 주도하는 면역 메커니즘을 제안합니다Research Article Published on 2021-07-142022-09-10 Journal: PLoS Pathogens [Category] SARS, 바이오마커, [키워드] accelerated Analysis approach Biomarker Biomarkers calibrated CD8 clinically Cohort Concentration COVID-19 Critical diagnostic disease Diversity driver Drivers driving expand experimental model experimental models feature identifying IFN IL-6 immune mechanism immune response immune responses immunological immunopathology in silico individual infected cell Inflammation inflammatory disease Intervention lead Longitudinal data Macrophage mathematical mathematical model maximum concentration outcome pathogen Pathogens Patient patient cohort patients Phenotypes predicted production rates reduced reducing regulate responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe COVID-19 Support T cell T cell depletion therapeutic targets treatment approaches Type I IFN understanding [DOI] 10.1371/journal.ppat.1009753 PMC 바로가기 [Article Type] Research Article
Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia뚜렷한 면역학적 특징은 심각한 COVID-19를 SARS-CoV-2에 의해 유발되지 않은 치명적인 폐렴과 구별합니다.Comparative Study Published on 2021-07-132022-09-11 Journal: Immunity [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, [키워드] adaptive alteration Analysis binding Biomarker cascade Cell change circulating ClinicalTrials COVID-19 COVID-19 patient Critical Cytometry driven by feature flow cytometry Frequency GM-CSF high-dimensional single cell analysis HLA HLA typing ICU patient ICU Patients immune Immune profile immune profiling immune signature Immunity immunological immunopathology Immunophenotyping Inflammatory response integration interfere longitudinal NKT outcome paralysis Patient peptide peptide binding strength peptides Pneumonia predicted Predictive SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides severe COVID-19 Single Cell single-cell spectral flow cytometry. T cell the patient translation Treatment strategies treatment strategy virus recognition [DOI] 10.1016/j.immuni.2021.05.002 PMC 바로가기 [Article Type] Comparative Study
Elevated Expression Levels of Lung Complement Anaphylatoxin, Neutrophil Chemoattractant Chemokine IL-8, and RANTES in MERS-CoV-Infected Patients: Predictive Biomarkers for Disease Severity and MortalityOriginal Article Published on 2021-07-072023-06-15 Journal: Journal of Clinical Immunology [Category] MERS, [키워드] chemokine complement system cytokine immunopathology lung MERS-CoV infection [DOI] 10.1007/s10875-021-01061-z PMC 바로가기 [Article Type] Original Article
The signal pathways and treatment of cytokine storm in COVID-19Review Article Published on 2021-07-072022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] 변종, 비임상, 임상, [키워드] acute respiratory distress affected Antibody-dependent enhancement capillary leak syndrome cells Characteristics characterized clinically COVID-19 COVID-19 pathogenesis current cytokine Cytokine storm death develop disease Disseminated intravascular coagulation downstream dysregulation effective Evidence Fever help IFN-I immune immunopathological immunopathology Infectious disease Infectious diseases Inflammatory diseases inflammatory signaling Intervention involved lymphopenia macrophages monocyte multiorgan failure pandemic pathway Pathways physically poor prognosis pro-inflammatory cytokine proportion receptor reduced Research responsible resulting secreted severe cases Signaling signaling pathway suggested Symptom syndrome tissue Treatment treatment strategy type I interferon [DOI] 10.1038/s41392-021-00679-0 PMC 바로가기 [Article Type] Review Article
Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis장기간 SARS-CoV-2 RNA 바이러스 배출 및 림프구감소증은 예후가 불량한 암 환자에서 COVID-19의 특징입니다Article Published on 2021-07-062022-09-10 Journal: Cell Death and Differentiation [Category] SARS, 유전자 메커니즘, 임상, 치료기술, [키워드] accompanied activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-RBD IgG antibodies association Blood Cancer cancer patient Cancer patients Cancer therapy carriers CD8 cells circulation coronavirus Coronavirus-2 correlated COVID-19 COVID-19 severity cycle threshold death Depletion DNA early phase Elevation Enterobacteriaceae Eomes exacerbate exhibited family members favor follicular granzyme granzyme B Gut hallmark higher risk IFN immature immunopathology Infection Infectious disease lymphocyte Lymphocyte count lymphopenia magnitude malignant disease mechanism Medical research metabolite metabolites Monocytes Nasopharyngeal swab nasopharyngeal swabs Neutrophils pandemic paradoxical pathway Patient PD-1 plasmablasts polyamine poor prognosis Prognostic markers Prolonged RBD IgG reduce respiratory RT-qPCR salt SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection serum severe COVID-19 significant changes in T-helper cells Viral Viral RNA Viral RNA shedding virus virus–host interaction virus–host interactions worsened [DOI] 10.1038/s41418-021-00817-9 PMC 바로가기 [Article Type] Article
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severityCOVID-19 질병 중증도의 핵심 매개체로서의 단핵구 구동 비정형 사이토카인 폭풍 및 비정상적인 호중구 활성화Article Published on 2021-07-052022-09-12 Journal: Nature Communications [Category] SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] adaptive immune system affected amplification Antigen approach Atypical CD8+ cell CD8+ cells cellular damage classical monocyte classical monocytes contribute COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patients COVID-19 severity Critical Critical disease cytokine cytokine level cytokine levels Cytokine storm disease severity driver expression Host immune response hypercytokinemia immune profiling immunopathology Infection interferon Interferon-gamma Local Macrophage macrophage activation syndrome monocyte Monocytes multiplex neutrophil neutrophil activation Neutrophil extracellular traps Neutrophils phenotype presenting reduced reduction in SARS-CoV-2 SARS-CoV2 System Systems biology T-lymphocyte T-lymphocytes tissue damage triggering viral infection virulence [DOI] 10.1038/s41467-021-24360-w PMC 바로가기 [Article Type] Article
Harnessing immunotherapy to combat COVID-19: A modern snake oil or silver bullet?COVID-19 퇴치를 위한 면역 요법 활용: 현대의 뱀 기름 또는 은탄?Review Published on 2021-07-012022-09-11 Journal: Thérapie [Category] SARS, 진단, 치료제, [키워드] (hydroxychloroquine) (remdesivir acute respiratory syndrome acute respiratory syndrome coronavirus Anti-viral antibodies Azithromycin caused clinical trial clinical trials Combination convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 serotherapy drug Epidemiology Health human monoclonal antibodies Human monoclonal antibody Hydroxychloroquine IFN-I immune response immune responses immunopathology Immunotherapy Infectious disease interfere interferon Interferon type I interferons intracellular pathogens mAbs modify monoclonal antibodies outcome Pathogenesis Pathogens Patient physician regimen Remdesivir respiratory SARS-CoV-2 serotherapy severe acute respiratory syndrome Coronavirus survival Treatment outcome [DOI] 10.1016/j.therap.2020.10.004 PMC 바로가기 [Article Type] Review
Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital MortalityCOVID-19 심각도 및 병원 내 사망률에 대한 예후 마커로서 아나필라톡신 및 염증성 사이토카인 보완Immunology Published on 2021-07-012022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] Activation Analysis anaphylatoxin anaphylatoxins C3a C5a changes in chemokine chemokines clinical disease clinical outcomes complement complement anaphylatoxins Complement pathway complement system complications COVID-19 COVID-19 patient COVID-19 severity Critical critical COVID-19 patient critical COVID-19 patients critical patients cytokine Cytokine storm Cytokines deaths dysregulation enrolled enzyme-linked immunosorbent enzyme-linked immunosorbent assay healthy control healthy controls highlight Hospitalization IgM antibody IgM antibody levels IL-1β IL-6 IL-8 immunopathology In-hospital in-hospital mortality infected with SARS-CoV-2 Inflammatory cytokine Inflammatory cytokines Inflammatory mediators Innate immunity Interaction interleukin investigated mediators mild cases mild COVID-19 patients mild patient mild patients Mortality Necrosis outcome Patient patients patients with COVID-19 positively correlated Potential treatment Prognosis prognostic properdin Protein RANTES SARS-COV-2 infection SARS-CoV-2 infections SARS‐CoV‐2 SARS‐CoV‐2 sera serum severe SARS Signaling significantly significantly higher survival group target Treatment strategies treatment strategy Tumor tumor necrosis tumor necrosis factor upregulated utility were measured [DOI] 10.3389/fimmu.2021.668725 PMC 바로가기 [Article Type] Immunology
Enhanced Expression of Autoantigens During SARS-CoV-2 Viral InfectionSARS-CoV-2 바이러스 감염 중 자가항원 발현 향상Immunology Published on 2021-06-302022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Activation Analysis Asymptomatic COVID-19 autoantigen Autoantigens Autoimmune Autoimmune disease Autoimmune diseases Autoimmunity Autopsy bioinformatics Blood conducted confirmed case confirmed cases COVID-19 COVID-19 infections datasets determine Effect enhanced evaluate expression level expression levels follow-up studies follow-up study homeostasis IFIH1 Immune homeostasis immunopathology in-silico Infection infections lead longitudinal low-density lung lung autopsies mononuclear cell mononuclear cells MPO neutrophil neutrophil activation overexpressed PADI4 PBMCs Peripheral blood Peripheral blood mononuclear cells plasma protein protein level protein levels PRTN3 PTPRN2 respiratory viral infection SAR-CoV-2 SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 viral severe COVID-19 severe COVID-19 infections severity of COVID-19 significantly single-cell dataset subset tissue Tolerance transcriptomic TRIM21 TSHR upregulated upregulation Viral viral infection viral infections Whole blood [DOI] 10.3389/fimmu.2021.686462 PMC 바로가기 [Article Type] Immunology