inactive – Page 11 – Communicable Diseases Research

Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2

편자박쥐 ACE2 orthologs에서 파생된 돌연변이는 SARS-CoV-2의 ACE2-Fc 중화를 향상시킵니다

Research Article

Published on 2021-04-092022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 변종,

Possible favorable lifestyle changes owing to the coronavirus disease 2019 (COVID-19) pandemic among middle-aged Japanese women: An ancillary survey of the TRF-Japan study using the original “Taberhythm” smartphone app

Research Article

Published on 2021-03-252022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS, SARS,

[키워드] adopted affected association BMI body mass index change coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic declined Effect Final inactive indicate Japanese pandemic Participants participated per day Period physical activity physically positive quarantine severity of COVID-19 turn Variation women
[DOI] 10.1371/journal.pone.0248935 PMC 바로가기 [Article Type] Research Article

Elucidation of interactions regulating conformational stability and dynamics of SARS-CoV-2 S-protein

Articles

Published on 2021-03-162022-10-28
Journal: Biophysical Journal [Category] COVID-19,

Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution

Article

Published on 2021-03-112022-10-04
Journal: Nature Communications [Category] SARS, 변종,

Simultaneous CD8 + T-Cell Immune Response against SARS-Cov-2 S, M, and N Induced by Endogenously Engineered Extracellular Vesicles in Both Spleen and Lungs

Article

Published on 2021-03-102022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] acute respiratory syndrome airways anti-SARS-CoV-2 antibody Antigen antigen-presenting cells approach C-terminal C-terminus CD8 CD8⁺ T cell immunity Cell coding coronavirus CTL detectable DNA Efficiency Evidence EVs expressing expression vector extracellular vesicle Extracellular vesicles fused fusion protein HIV-1 immune response Immunity in vivo inactive induce induced injected Intramuscular injection lung Lungs lymphocyte mice MOST Nef polypeptide Protein provided released response S1 and S2 SARS-CoV-2 SARS-CoV-2 antigen Simultaneous spleen T cell T-cells vaccination Vaccine vector viral antigens
[DOI] 10.3390/vaccines9030240 PMC 바로가기 [Article Type] Article

Impact of COVID-19 lockdown on physical activity and sedentary behaviour in Dutch cardiovascular disease patients

Original Article

Published on 2021-02-252022-10-30
Journal: Netherlands Heart Journal [Category] COVID-19,

Detection of SARS-CoV-2 in fecal samples with different pretreatment methods and PCR kits

다양한 전처리 방법 및 PCR 키트로 대변 샘플에서 SARS-CoV-2 검출

Research Article

Published on 2021-02-192022-09-10
Journal: BMC Microbiology [Category] MERS, 치료기술,

[키워드] adjusted asymptomatic infection best can be used choice correlated COVID-19 COVID-19 patient COVID-19 patients detection detection rate distribution fecal Fecal sample fecal samples Fecal–oral transmission Fecal–oral transmission Gastrointestinal gastrointestinal symptoms groups had no inactivation inactive lead less N gene no significant difference nucleic acid test ORF1 ORF1ab PBS PCR phosphate Phosphate Buffered Saline positive rate real-time RT-PCR reported Result RT-PCR RT-PCR diagnostic kits RT-PCR kits Safe Saline SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleic acid SARS-CoV-2 RNA Severe case severe cases severity severity of illness significant difference supplementary material Symptom the disease Trizol was obtained was related while
[DOI] 10.1186/s12866-021-02118-0 PMC 바로가기 [Article Type] Research Article

Action of Dipeptidyl Peptidase‐4 Inhibitors on SARS‐CoV‐2 Main Protease

Communication

Published on 2021-02-172022-10-31
Journal: ChemMedChem [Category] COVID-19, SARS,

[키워드] Action analogue Analysis approved binding blocked catalytic activity COVID‐19 COVID19 docking DPP-4 drug candidate Drug repurposing enzymatic assay functional inactive inhibitor inhibitors linagliptin M pro main protease (M^pro) pandemic protease SARS-CoV-2 SARS‐CoV‐2 suggested
[DOI] 10.1002/cmdc.202000921 PMC 바로가기 [Article Type] Communication

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

구조 유도 다가 나노바디는 SARS-CoV-2 감염을 차단하고 돌연변이 탈출을 억제합니다

Research Article

Published on 2021-02-122022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, MERS, 변종, 진단, 치료기술,

[키워드] absence activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Administered alpaca antibodies antibody Attention battle binding binding mode binding modes Bivalent catalyzed caused Cell cellular membrane cellular membranes change Combination combinations complex conformation conformational change Consequences coronavirus COVID-19 cryo-EM Crystallography determined by domain effective epitope Epitopes escape mutant escape mutants Evolution experiment experiments expression fusion Health care health care systems High-risk patients immune system immunization immunized inactivated inactivated virion inactive independent induce Infection information inhalation inhibit inhibited Interaction interactions lead llama mechanism Microscopy monoclonal antibodies multivalent mutants nanobodies nanobody neutralization neutralize neutralized Neutralizing Neutralizing activity observation offer pandemic passive immunization Perspective postfusion Premature Prevent prevented Protein RBD RBDs receptor receptor ACE2 Receptor binding Receptor binding domain respiratory resulting reveal Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 spike trimer Science severe acute respiratory syndrome Coronavirus Simultaneous Society Spike protein spike trimers Spread stomatitis strength Structure structures suppress suppressed target membrane target membranes the RBD the SARS-CoV-2 the spike protein to define Trigger triggered triggering triggers trimeric spike trivalent Vaccines variable vesicular stomatitis vesicular stomatitis virus Viral viral escape viral infection viral infections viral spike protein virion virions virus X-ray crystallography
[DOI] 10.1126/science.abe6230 PMC 바로가기 [Article Type] Research Article

Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients

Research

Published on 2021-02-082022-11-01
Journal: Critical Care [Category] COVID-19, MERS,

[키워드] Activation anaphylatoxin antibodies Bilirubin block carboxypeptidase Carboxypeptidase B cascade CCK-8 assay Cell cell-free DNA Coagulation Coagulopathy complement component contribute COVID-19 COVID-19 patient COVID-19 patients CPB2 Critically ill patient cytotoxicity Degradation degrade demonstrated Disease progression endothelial enzyme evaluated Ex vivo Extracellular help homolog Immunofluorescent staining immunothrombosis inactive Intervention lactate dehydrogenase myeloperoxidase NET NETs neutrophil Neutrophil extracellular trap pathological role plasma prevalent Prevent proinflammatory mediators recruited Regulation Result risk of death thrombosis thrombotic event total bilirubin Vascular vascular endothelial cell with COVID-19
[DOI] 10.1186/s13054-021-03482-z PMC 바로가기 [Article Type] Research