infiltration – Page 11 – Communicable Diseases Research

SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for spillback to New World rodents

사슴 쥐 사이의 SARS-CoV-2 감염, 신경병증 및 전파: 신세계 설치류로의 유출에 대한 의미

Research Article

Published on 2021-05-192022-09-10
Journal: PLoS Pathogens [Category] 진단, 치료기술,

Hypoalbuminemia on admission in COVID-19 infection: An early predictor of mortality and adverse events. A retrospective observational study

Observational Study

Published on 2021-05-072022-10-05
Journal: Medicina clínica [Category] SARS, 임상,

[키워드] 95% CI Acute heart failure Acute kidney injury acute phase acute respiratory distress Admission adverse event adverse events age Analysis analyzed association C- reactive protein Characteristics chest X-ray Cohort collected Comorbidities Comorbidity condition consecutive patients COVID-19 COVID-19 patients creatinine death Deceased demographic diagnosis of COVID-19 discharged Diseases English Factores predictivos de episodios adversos Factores predictivos de la mortalidad Gender help high risk Hipoalbuminemia hospital Hypoalbuminemia identify in-hospital mortality index Infection infiltration inflammatory markers Inflammatory response Laboratory lactate dehydrogenase life-threatening Lymphocyte count macrophage activation syndrome Mortality multivariable multivariable Cox regression nonsurvivor outcome patients with SARS-CoV-2 Predictors of adverse events Predictors of mortality renal retrospective SARS-CoV-2 Sepsis serum albumin severe adverse events significantly Spanish survivor Symptom syndrome were assessed
[DOI] 10.1016/j.medcli.2020.12.018 PMC 바로가기 [Article Type] Observational Study

Case report: histopathology and molecular pathology analysis on enteric tissue of a COVID-19 patient

증례보고: 코로나19 환자의 장 조직에 대한 조직병리학 및 분자병리학 분석

Case Reports

Published on 2021-05-052022-09-11
Journal: Diagnostic Pathology [Category] SARS, 바이오마커, 진단, 치료기술,

[키워드] accompanied Analysis analyzed Antigen Case report CD3 CD4 CD68 Cell CMV cocci COVID-19 COVID-19 patient cytomegalovirus determined by distribution EBV enteric symptoms eosin examined Gastrointestinal infection Gram staining hematoxylin hematoxylin & eosin hemorrhage Herpe herpes simplex virus Histopathology immunohistochemistry In situ hybridization infiltration Inflammatory intestinal intestinal macrophage intestinal macrophages lymphocyte lymphocyte infiltration Lymphocytes Macrophage macrophages Methenamine Molecular pathology mucosal mucosal epithelium mycobacteria tuberculosis Necrosis neutrophil neutrophil infiltration overlapped PAS patient with COVID-19 performed Periodic positive proliferation Result RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA silver spore stain staining susceptibility tissue Tuberculosis with COVID-19
[DOI] 10.1186/s13000-021-01082-7 PMC 바로가기 [Article Type] Case Reports

Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection

인간의 신장은 신종 중증급성호흡기증후군 코로나바이러스 2 감염의 표적이 된다

Article

Published on 2021-05-042022-09-10
Journal: Nature Communications [Category] SARS, 임상, 진단, 치료법,

[키워드] accumulate Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AKI angiotensin angiotensin converting enzyme Antigen antigens Autopsy C5b-9 CD68 CD68+ macrophage clinical parameter Clinical parameters Comorbidities Comorbidity complement coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient damage-associated molecules develop double staining Elderly patient elderly patients ENhance eosin exhibited expression Haematoxylin heart failure Histopathology Human human kidney hypertension hypoxic hypoxic damage immunofluorescence immunohistochemistry In situ hybridization infect Infection infiltration kidney Kidney diseases kidneys laboratory-confirmed lead macrophages moderate moderate to severe nucleocapsid Pathogenesis Patient Post-mortem prostaglandin respiratory Retrospective analysis SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein staining Trigger triggers Viral Viral RNA was performed
[DOI] 10.1038/s41467-021-22781-1 PMC 바로가기 [Article Type] Article

Blood neutrophils from children with COVID-19 exhibit both inflammatory and anti-inflammatory markers

COVID-19에 걸린 어린이의 혈액 호중구는 염증 및 항염증 마커를 모두 나타냅니다

Observational Study

Published on 2021-05-012022-08-31
Journal: EBioMedicine [Category] SARS, 바이오마커, 임상, 진단,

[키워드] Activation acute lung injury Adhesion Molecule adhesion molecules Adults analyzed Anti-inflammatory Asymptomatic Blood Blood samples Buenos Aire Buenos Aires CD11b CD64 CD66b Cell-adhesion molecules cell-free DNA children children with COVID-19 circulating neutrophil circulating neutrophils Concentration COVID-19 cytokine cytokine production Cytokines DNA ELISA expression Fcγ receptor flow cytometry fluorometry healthy children healthy controls HLA-DR IgG IgG antibodies IgG antibody immune response infiltration Inflammatory inhibitory receptor Inhibitory Receptors L-selectin low expression lower expression Lung function Lung injury marker Mild MIS-C Moderate COVID-19 NET NETs neutrophil Neutrophils no differences observational study PD-L1 pediatric pediatric COVID-19 phenotype plasma Plasma levels Prevent promotion quantified receptor respiratory respiratory symptoms SARS-CoV-2 Science serum severe COVID-19 severe respiratory symptom severe respiratory symptoms Spike protein supported syndrome technology the spike protein tissue university was performed were measured
[DOI] 10.1016/j.ebiom.2021.103357 PMC 바로가기 [Article Type] Observational Study

Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU

중환자실 외부에서 조기 입원 및 조기 항바이러스 치료를 받은 중증도가 낮은 코로나19 환자의 결과

Observational Study

Published on 2021-04-302022-09-10
Journal: Turkish Journal of Medical Sciences [Category] SARS, 임상, 치료제,

[키워드] Admission Antibody test antiviral therapy Antiviral treatment Azithromycin Care Case fatality rate Case series Clinical data clinically suspected collected Combination COVID-19 COVID-19 adult patient COVID-19 pandemic COVID-19 patient COVID-19 patients diagnosed Diseases duration of hospitalization evaluated Fatality rate Favipiravir hospital hospital ward Hospital wards Hospitalization Hospitalized Hydroxychloroquine hydroxychloroquine plus azithromycin ICU infiltration internal internal medicine Laboratory male management material median median age Medicine microbiologically Mild Mild-to-moderate moderate disease noncritical illness Patient patients patients died PCR radiological finding regimen regimens Result severe pneumonia single-center study Symptom the patient transferred treated university university hospital with COVID-19
[DOI] 10.3906/sag-2006-173 PMC 바로가기 [Article Type] Observational Study

Pleiotropic Effects of Tetracyclines in the Management of COVID-19: Emerging Perspectives

Pharmacology

Published on 2021-04-232022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Admission aerobic Anti-inflammatory ARDS Bacteria bacteriostatic antibiotics caspase caused Cell Chloroquine clinical trial complications coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient Cytokine storm doxycycline Effect effective Gram-negative bacteria high risk ICU IL-1 Infectious disease infiltration inhibit intensive care lymphopenia management matrix metalloproteinase mechanical ventilation mechanism mitochondrial Necrosis other coronavirus pathway Pathways Pneumonia proliferation QT interval reducing reduction SARS-CoV-2 Severe case syndrome synergistic Tetracycline tetracyclines treat
[DOI] 10.3389/fphar.2021.642822 PMC 바로가기 [Article Type] Pharmacology

Giloy Ghanvati ( Tinospora cordifolia (Willd.) Hook. f. and Thomson) Reversed SARS-CoV-2 Viral Spike-Protein Induced Disease Phenotype in the Xenotransplant Model of Humanized Zebrafish

Pharmacology

Published on 2021-04-192022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] A549 artificial ventilation ayurved Ayurveda caused changes in comparable correlated cough disease disease phenotype distress dosage epithelial cell feature Fever giloy ghanvati granulocyte healthcare Hook human lung humanized Immune cell induced Infection infiltration inflamation Inflammation lack Macrophage Model phenotype pro-inflammatory renal tissue reported respiratory reversed SARS-CoV-2 SARS–CoV–2 spike-protein swim bladder symptomatic systemic damage targeted therapy the disease the SARS-CoV-2 therapy tinopsora cordifolia Traditional Treatment treatment group viral disease were given xenotranplantation zebrafish
[DOI] 10.3389/fphar.2021.635510 PMC 바로가기 [Article Type] Pharmacology

Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor Microenvironment

Immunology

Published on 2021-04-192022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

[키워드] accumulating Acidic activate addition Amino acid amino acid transporter anti-tumor immunity c-MYC Cancer caused Cell cell metabolism chimeric antigen receptor demonstrated ENhance Evidence Express expression function functions Glucose Glutamine growth hypoxic Immune cell immune cells immunometabolism Immunotherapy induce infiltration Invasion leucine limitation metabolism metabolites mTORC1 Natural killer cells nutrient transporters overcome plasma membrane Potential proliferation promote regulatory pathway required robust SLC1A5 SLC3A2 SLC7A5 Strategy subcellular subunit T cells targeting therapy transcription factor Tumor tumor microenvironment tumors
[DOI] 10.3389/fimmu.2021.624324 PMC 바로가기 [Article Type] Immunology

The efficacy of N-Acetylcysteine in severe COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial

중증 COVID-19 환자에서 N-아세틸시스테인의 효능: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-04-122022-09-10
Journal: Trials [Category] 임상,

[키워드] 1:1 Acetylcysteine Activation Acute respiratory infection addition Admission All participant All participants antioxidant effect antioxidant effects appearance approved Arm assigned Bandar Abba Bandar Abbas baseline Blinding block randomization Care caused cell damage clinical clinical condition clinical trial clinical trials Committee comparator Comparator group composite endpoint control group Controlled clinical trial COVID-19 discharge dissemination dose Effects Efficacy element ethics committee evaluate excluded expected FIVE Health Health care help Hospitalization hypersensitivity Hypoxemia infiltration inflammatory factors injection intensive care intensive care unit Intervention intervention group Intravenous injection investigator Lactate lactate dehydrogenase LDH lead Local lung lung failure lymphopenia mechanical ventilation Medical Science Medical Sciences medication minute N-acetylcysteine number objective outcome oxygen oxygen partial pressure parallel-group partial pressure participant Patient patients Pharmaceutical Company Phase 3 Placebo positive PCR test Pregnancy primary endpoint principal investigator Progressive protocol random randomised randomised controlled trial randomization Randomized Randomly reactive oxygen species receive recruitment Registered registry reported respiration rate respiratory infection Saline Sample size SARI SARS-CoV-2 virus sequence severe COVID-19 severe COVID-19 patient severe COVID-19 patients Side effect Standard Standard of care Sterile sterile water Study protocol supplementary material technology test results the ethics committee the patient the SARS-CoV-2 virus Treatment Trial registration university water water for injection website were measured written consent
[DOI] 10.1186/s13063-021-05242-4 PMC 바로가기 [Article Type] Letter