Cold-passaged isolates and bat-swine influenza a chimeric viruses as modified live-attenuated vaccines against influenza a viruses in pigsArticle Published on 2022-10-122023-06-24 Journal: Vaccine [Category] 신종인플루엔자, [키워드] Bat influenza chimera Cold-passaged influenza virus influenza A virus Modified live-attenuated vaccine swine [DOI] 10.1016/j.vaccine.2022.09.013
Transchromosomic bovines-derived broadly neutralizing antibodies as potent biotherapeutics to counter important emerging viral pathogens with a special focus on SARS-CoV-2, MERS-CoV, Ebola, Zika, HIV-1, and influenza A virusSARS-CoV-2, MERS-CoV, 에볼라, 지카, HIV-1 및 인플루엔자 A 바이러스에 특히 중점을 두고 중요한 신흥 바이러스 병원체에 대응하는 강력한 생물 치료제로서의 형질전환 소 유래 광범위 중화 항체Review Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjuvant adjuvants Alpha animals antibody antibody-based therapies Antiviral approach approved assist Beta Biotherapeutics blocked bovine bovine-derived biotherapeutics Clinical studies colostrum convalescent coronavirus creating Delta disease Donor E484K Ebola effective Efficiency emerging viruses Epsilon Gamma highlight HIV-1 Human Human immunodeficiency virus human immunodeficiency virus type 1 human infection human infections hyperimmunization immune immunoreactivity Immunotherapy Influenza influenza A influenza A virus Iota K417N L452R Lambda MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus mutations N501Y neutralization neutralized Neutralizing Neutralizing activity neutralizing antibody omicron Omicron variants outbreak P681R Pandemics platform polyclonal antibodies polyclonal antibody produced Protective respiratory respiratory syndrome coronavirus robust Safe SARS-CoV-2 serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown T478K therapeutic option transchromosomic bovines. Vaccine variant variants variants of concern variants of interest Viral viral infection viral infections viral pathogen VOCs VOIs Zika [DOI] 10.1002/jmv.27907 PMC 바로가기 [Article Type] Review
5-Methoxyflavone-induced AMPKα activation inhibits NF-κB and P38 MAPK signaling to attenuate influenza A virus-mediated inflammation and lung injury in vitro and in vivoArticle Published on 2022-09-302023-06-14 Journal: Cellular & Molecular Biology Letters [Category] Fulltext, 신종인플루엔자, [키워드] 5-Methoxyflavone AMPKα Anti-inflammatory Antiviral influenza A virus [DOI] 10.1186/s11658-022-00381-1 PMC 바로가기
A Recombinant VSV-Based Bivalent Vaccine Effectively Protects against Both SARS-CoV-2 and Influenza A Virus InfectionArticle Published on 2022-09-282022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 신종인플루엔자, 진단, [키워드] Amino acid animal Bivalent bivalent vaccine C-terminal Cellular immune response conserved contagious COVID-19 Delta delta variant develop domain Ebola ectodomain Efficacy Evidence fused global public health glycoprotein H1N1 H3N2 hamster humoral immunization infections Infectious disease Influenza influenza A virus Influenza virus influenza viruses M2 protein mice Neutralizing neutralizing antibody Point mutation PROTECT Protein provide recombinant reduced Respiratory disease respiratory droplet respiratory viral S2 domain SARS-CoV-2 SARS-CoV-2 Delta variant SARS-CoV-2 SP SARS-CoV-2 variant shown significantly Spike protein the RBD threat transmitted Vaccine vaccine candidate vaccine platform variant vesicular stomatitis virus VSV VSV vector [DOI] 10.1128/jvi.01337-22 PMC 바로가기
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recoveryArticle Published on 2022-09-282022-11-15 Journal: Science Translational Medicine [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome affected animal model change coronavirus correlated COVID COVID-19 demonstrated detectable exceeded hamster highlight host response Human IAV individual Infection Infectious virus influenza A virus Injury interferon response kidney lack lung mechanism molecular mechanism olfactory Olfactory epithelium PASC pathology Perturbation Proinflammatory cytokine response Result SARS-CoV-2 SARS-COV-2 infection sustained T cell activation tissue transcriptional change unique viral clearance [DOI] 10.1126/scitranslmed.abq3059 PMC 바로가기
Simultaneous Detection of RIG-1, MDA5, and IFIT-1 Expression Is a Convenient Tool for Evaluation of the Interferon-Mediated ResponseArticle Published on 2022-09-212022-11-15 Journal: Viruses [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] A549 cell acute phase assumed both virus clinical Course cytosolic cytosolic sensors detection disease onset Disease progression donors elevated evaluated expression Genes H3N2 immune response in vitro in vitro transcribed RNAs influenza A influenza A virus inhibit interferon-stimulated gene interferons ISGs MDA5 Mild-to-moderate mRNA expression mRNA level multiple mechanism multiplex not differ observation onset of symptoms pathogenesis of SARS-CoV-2 patients with influenza post infection qPCR qPCR assay remained response RNA RNAs SARS-CoV-2 SARS-CoV-2 patient Signaling Simultaneous SOCS-1 the disease transcribed transfected with type I virus White blood cell White blood cells worsening [DOI] 10.3390/v14102090 PMC 바로가기
Chemically Modified Bovine β-Lactoglobulin as a Broad-Spectrum Influenza Virus Entry Inhibitor with the Potential to Combat Influenza OutbreaksArticle Published on 2022-09-162022-11-15 Journal: Viruses [Category] SARS, 신종인플루엔자, 진단, 치료제, [키워드] acute respiratory syndrome administration binds bovine bovine β-lactoglobulin broad-spectrum charged residues chemical modification combat coronavirus effective Efficacy highly pathogenic HIV host cells HPV Human immunodeficiency virus human papillomavirus in vitro in vivo Infection infections Influenza influenza A influenza A virus influenza vaccines Influenza virus inhibiting inhibitor intranasal lack mice outbreak Outbreaks Potential Prevent prevention Prophylactic SARS-CoV-2 sialic acid subunit the receptor-binding domain viral entry viral entry inhibitor. viruses [DOI] 10.3390/v14092055 PMC 바로가기
Low prevalence of influenza A strains with resistance markers in Brazil during 2017-2019 seasonsArticle Published on 2022-09-142023-06-23 Journal: Frontiers in Public Health [Category] 신종인플루엔자, [키워드] adamantane baloxavir marboxil influenza A virus Neuraminidase (NA) inhibitors oseltamivir resistance [DOI] 10.3389/fpubh.2022.944277 PMC 바로가기
[Effect and mechanism of acupoint injection on influenza A virus induced pneumonia in mice]Article Published on 2022-09-122023-06-23 Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion [Category] 신종인플루엔자, [키워드] acupoint injection Inflammatory response influenza A virus oxidative stress Viral pneumonia [DOI] 10.13703/j.0255-2930.20210713-k0002
Possible bidirectional human-swine and subsequent human-human transmission of influenza virus A(H1N1)/2009 in JapanCase Reports Published on 2022-09-012023-06-23 Journal: Zoonoses and Public Health [Category] 신종인플루엔자, [키워드] H1N1 subtype influenza A virus orthomyxoviridae infections swine diseases veterinary medicine zoonoses [DOI] 10.1111/zph.12960 [Article Type] Case Reports