inhibitory – Page 11 – Communicable Diseases Research

Disruption of the Golgi Apparatus and Contribution of the Endoplasmic Reticulum to the SARS-CoV-2 Replication Complex

Article

Published on 2021-09-092022-10-28
Journal: Viruses [Category] COVID-19, SARS,

Persistent High Percentage of HLA-DR + CD38 high CD8 + T Cells Associated With Immune Disorder and Disease Severity of COVID-19

COVID-19의 면역 장애 및 질병 중증도와 관련된 HLA-DR + CD38 높은 CD8 + T 세포의 지속적인 높은 비율

Immunology

Published on 2021-09-092022-09-11
Journal: Frontiers in Immunology [Category] SARS, 바이오마커,

[키워드] apoptotic Beijing blood sample Blood samples Care caused CD38 CD8 chemokines Clinical and laboratory data collected coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patients critical cases Cytokines died disease severity disease severity of COVID-19 dysregulation Ebola evaluated examined expression Factor flow cytometric Growth factors Health crisis heterogeneous HLA-DR Hospital admission Hospitalization immune disorder immune disorders indicated infected with SARS-CoV-2 Influenza influenza infection inhibitory killing laboratory data lymphopenia manifested Mild moderate Multiplex assay outbreak overactivation Patient percentage persistent Progressive public health crisis recruited reported Result Retrospective study SARS-COV-2 infection sensitivity Serum level serum levels severe cases severe COVID-19 severe COVID-19 patients Severe patient severe patients severity stimulatory subset supported systemic inflammation T cell T cells tissue injury transcriptional regulation
[DOI] 10.3389/fimmu.2021.735125 PMC 바로가기 [Article Type] Immunology

Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics

Article

Published on 2021-09-082022-10-04
Journal: Scientific Reports [Category] SARS, 치료제,

Identification of potential plant bioactive as SARS-CoV-2 Spike protein and human ACE2 fusion inhibitors

SARS-CoV-2 스파이크 단백질 및 인간 ACE2 융합 억제제로서 잠재적인 식물 생리활성 확인

Article

Published on 2021-09-012022-09-11
Journal: Computers in biology and medicine [Category] SARS, 치료제,

Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus Protease

Article

Published on 2021-08-302022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS,

[키워드] addition Administered amino acid residue Antiviral agents binding binding domain can be used complex complexes coronavirus disease correlated Course COVID-19 COVID-19 patients demonstrated development disease docked docking docking result docking score drug candidate drug design effective exhibited flavonols Free energy calculations in silico in silico Approach inhibitor inhibitory Interaction investigated involved less Ligand M pro M^Pro MDs MM/GBSA molecular Molecular dynamics simulation molecular target molecule Mutation myricetin Myricitrin natural natural products protein-ligand interaction reduced Remdesivir residue RMSD RMSF rutin SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro selected Source stability Treatment Vaccine
[DOI] 10.3390/ijms22179431 PMC 바로가기 [Article Type] Article

Targeting CoV-2 spike RBD and ACE-2 interaction with flavonoids of Anatolian propolis by in silico and in vitro studies in terms of possible COVID-19 therapeutics

Article

Published on 2021-08-302022-10-29
Journal: Turkish Journal of Biology [Category] COVID-19,

Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay

Resource and Technical Advance

Published on 2021-08-232022-10-30
Journal: JCI Insight [Category] COVID-19, SARS,

Activation or exhaustion of CD8 + T cells in patients with COVID-19

Review Article

Published on 2021-08-192022-11-01
Journal: Cellular and Molecular Immunology [Category] COVID-19, Fulltext, MERS,

Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors

Article

Published on 2021-08-122022-10-30
Journal: Molecules [Category] COVID-19, SARS,

Sustained expression of inflammatory monocytes and activated T cells in COVID‐19 patients and recovered convalescent plasma donors

Original Article

Published on 2021-08-062022-10-30
Journal: Immunity, Inflammation and Disease [Category] COVID-19, MERS, SARS,

[키워드] activated T cell activated T cells activating acute respiratory syndrome Analysis analyzed B cell B‐cell Biliary CCR2 CD8 cellular response chemotactic convalescent plasma coronavirus coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 CX3CR1 cytokine cytokine production Cytokines disease Donor endothelial expected expression flow cytometry group growth healthy individual healthy subjects IL‐6 Immune cell immune cells immune response Immunity Infection infiltration Inflammatory marker inflammatory monocyte inflammatory protein inhibitory Leptin Ligand Lung injury Macrophage main mechanism Migration Mild MIP moderate monocyte Monocyte activation Monocytes New Patient patients performed Plasma cytokine positive Protein Proteins proteomics receptor recovered patient recovered patients recruited reduction in Result Saa1 serum significant increase sustained T cells target tissue Vascular
[DOI] 10.1002/iid3.476 PMC 바로가기 [Article Type] Original Article