Association between Hypomagnesemia, COVID-19, Respiratory Tract and Lung DiseaseArticle Published on 2021-09-172022-10-28 Journal: The Open Respiratory Medicine Journal [Category] COVID-19, [키워드] absence CD8+ T lymphocytes Cell controlled trials COVID-19 COVID-19 disease Cytokine storm cytotoxic function death diabete Effects group hypertension interfere intravascular coagulation Lung diseases Magnesium Magnesium deficiency metabolism molecular natural killer obesity pathology pathway patients with COVID-19 renin-angiotensin system reported respiratory SARS-CoV-2 SARS-COV-2 infection Supportive treatment tract triggered type I [DOI] 10.2174/1874306402115010043 PMC 바로가기 [Article Type] Article
Repurposing Cardiac Glycosides: Drugs for Heart Failure Surmounting VirusesReview Published on 2021-09-162022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] anticancer Antiviral antiviral action Antiviral compounds approach approved Cancer cancer treatment cardiac cardiac steroids clinical trial condition coronavirus COVID-19 digitoxin digoxin drug Drug evaluation Drug repurposing evaluate example failure glycoside heart heart failure host cell interfere lanatoside C mechanism Na+/K+-ATPase ouabain reported repurposing Research SARS-CoV-2 pandemic significantly tested Topic viral life cycle virus entry [DOI] 10.3390/molecules26185627 PMC 바로가기 [Article Type] Review
Laboratory-Generated DNA Can Cause Anomalous Pathogen Diagnostic Test Results실험실에서 생성된 DNA가 비정상적인 병원체 진단 테스트 결과를 유발할 수 있음Research Article Published on 2021-09-152022-09-12 Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Amplicon assays Can cause caused Contact contaminant contaminated surface coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 pandemic COVID-19 testing diagnostic diagnostic testing diagnostics DNA focus in some independent individual instances interfere Isolation Laboratory marketplace molecular new SARS-CoV-2 nucleic acid nucleic acids object observation pandemic positive Primary infection prophylactic measure public health Public sphere quarantine Research researcher resources Result SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 testing severe acute respiratory syndrome Coronavirus Surveillance surveillance testing Symptom Test traction transfer Transmission was used widespread [DOI] 10.1128/Spectrum.00313-21 PMC 바로가기 [Article Type] Research Article
“Bucket brigade” using lysine residues in RNA-dependent RNA polymerase of SARS-CoV-2SARS-CoV-2의 RNA 의존성 RNA 중합효소에 라이신 잔기를 사용한 "버킷 여단"Article Published on 2021-09-072022-09-11 Journal: Biophysical Journal [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 all-atom molecular dynamics simulations atomic level ATP binding site Brigade carried contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 distance drug target expected Favipiravir interfere Ligand ligands lysine mechanism molecular dynamics Molecular dynamics simulation nucleoside nucleotide performed RdRP reached Remdesivir Replication residue RNA RNA genome RNA-dependent RNA polymerase SARS-CoV-2 severe acute respiratory syndrome Coronavirus thought [DOI] 10.1016/j.bpj.2021.07.026 PMC 바로가기 [Article Type] Article
Engineering of 2D nanomaterials to trap and kill SARS-CoV-2: a new insight from multi-microsecond atomistic simulationsModeling Article Published on 2021-09-032022-11-01 Journal: Drug delivery and translational research [Category] COVID-19, COVID19(2023년), SARS, [키워드] 2D nanomaterials Abstract ACE2 acute respiratory syndrome addition antiviral drugs approaches caused computational method coronavirus coronavirus disease COVID-19 deformation diagnostic Engineering inhibiting Interaction interfere investigated kill M pro MPro Mask Molecular dynamic Prevent Prophylactic protease Protein receptor reduce SARS-CoV-2 spike Spike protein supplementary material surface protein tested the spike protein Transmissibility two-dimensional Vaccines variety [DOI] 10.1007/s13346-021-01054-w PMC 바로가기 [Article Type] Modeling Article
New targets for drug design: importance of nsp14/nsp10 complex formation for the 3′-5′ exoribonucleolytic activity on SARS-CoV-2약물 설계를 위한 새로운 표적: SARS-CoV-2에 대한 3'-5' 엑소리보핵분해 활성에 대한 nsp14/nsp10 복합체 형성의 중요성Article Published on 2021-09-012022-09-11 Journal: The Febs Journal [Category] SARS, 신약개발, 치료제, [키워드] activities activity Amino acid amino acids antagonist antiviral drugs assembly biochemical C-terminal catalytic complex Consequences conserved coronavirus Coronaviruses Critical DEDD disrupt domain ExoN extreme global pandemic implication in vitro in vitro activity independent independent of inhibitor inhibitors Interaction interfere interferon involved life cycle mapping molecular Molecular modeling motif MTase multifunctional protein N-terminal New nsp10 nsp14 other coronaviruses pathogenesis of SARS-CoV-2 performed Protein Replication required residue RNase SARS-CoV-2 SARS-CoV-2 virus stimulated target triggered upregulating virus [DOI] 10.1111/febs.15815 PMC 바로가기 [Article Type] Article
Design of advanced siRNA therapeutics for the treatment of COVID-19Short communication Published on 2021-09-012022-10-05 Journal: Meta Gene [Category] 치료법, [키워드] acute SARS-CoV-2 infection affecting blocker COVID-19 Efficacy evaluated expected globe Human genome inhibit inhibitor interfere mRNA mRNA expression predicted qRT-PCR reduction in RNA Safe SARS-CoV-2 siRNA siRNAs tested the SARS-CoV-2 virus Therapeutic approach Treatment variety viral disease viral mRNA virus replication viruses [DOI] 10.1016/j.mgene.2021.100910 [Article Type] Short communication
Doxycycline Inhibition of a Pseudotyped Virus Transduction Does Not Translate to Inhibition of SARS-CoV-2 Infectivity의사 타입 바이러스 형질 도입의 독시사이클린 억제는 SARS-COV-2 감염성의 억제로 해석되지 않는다.Article Published on 2021-09-012022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] angiotensin angiotensin-converting enzyme 2 anti-viral activity approach binding biological processe biological processes caused Clinical data clinical trial clinical trials clinically Compound compounds COVID-19 criteria doxycycline expressing HEK-293 in vitro Infection Infectivity information inhibited inhibition interfere mechanism not affect pandemic platform Pleiotropic effects Pseudotyped virus receptor Replication replication of SARS-CoV-2 resources SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 virus Spike protein Spread surface plasmon resonance T cell T cells tetracyclines the SARS-CoV-2 virus the spike protein therapeutic transduction Vero E6 virus [DOI] 10.3390/v13091745 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19SARS-COV-2 스파이크 단백질 S1은 섬유소 분해에 내성이있는 피브린 (OGEN)을 유도합니다.Diagnostics & Biomarkers Published on 2021-08-272022-09-01 Journal: Bioscience Reports [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus added Blood blood flow change characterized circulation complement contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19 positive patient electron and fluorescence microscopy electron microscopy FIBRIN Fibrin(ogen) fibrinolysis fluorescence microscopy healthy hypercoagulability Hypercoagulation impairment implication induce Infection interfere lung Lungs mass spectrometry Microclot observation ogen Pathologies patients plasma plasma sample plasma samples Platelet platelet-poor plasma Platelets positive patients Protein prothrombin respiratory S1 subunit SARS-CoV-2 spike protein severe acute respiratory syndrome coronavirus 2 Spike protein spike protein S1 Spike protein Sa Treatment trypsinization [DOI] 10.1042/BSR20210611 PMC 바로가기 [Article Type] Diagnostics & Biomarkers
Identification of lectin receptors for conserved SARS‐CoV‐2 glycosylation sitesArticle Published on 2021-08-232022-10-31 Journal: The EMBO Journal [Category] COVID-19, MERS, SARS, [키워드] atomic binding Cell CLEC4G conserved Critical glycosylated glycosylation glycosylation site identification immunology implication infections Interaction interfere involved lectin mammalian Microbiology, Virology & Host Pathogen Interaction Microscopy New Post-translational Modifications & Proteolysis probe Protein RBD real time receptor Receptor binding domain reduced residue robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 spike SARS‐CoV‐2 significantly spike sugar therapeutic intervention therapeutic interventions therapy trimeric Vaccinations variant variants viral entry [DOI] 10.15252/embj.2021108375 PMC 바로가기 [Article Type] Article