Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 감염 역학 및 예방접종 가구의 면역 반응Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] anti antibody Antibody neutralization autoantibody Autoimmunity Breakthrough infection Comorbidities complex coronavirus 2 COVID-19 infection Dynamics household Immunity index case interferon interferon autoantibody. Person postvaccination Prevent respiratory response SARS-CoV-2 SARS-CoV-2 vaccine severe disease Transmission type 1 interferon vaccinated individual while [DOI] 10.1093/cid/ciac029 PMC 바로가기 [Article Type] Article
Clinical Performance of a Standardized Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Interferon-γ Release Assay for Simple Detection of T-Cell Responses After Infection or Vaccination감염 또는 백신 접종 후 T-세포 반응의 간단한 검출을 위한 표준화된 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 인터페론-γ 방출 분석의 임상 성능Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료기술, [키워드] 19 2 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 best Cell cell response Chain Reaction clinical convalescent Convalescent patients coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 dependent on detection disease severity Euroimmun evaluated Follow-up Germany healthy IFN-γ IFN-γ response IFN-γ responses IGRA immune response individual Infection interferon interferon-γ magnitude Mild disease mild infections Neutralizing antibodies neutralizing antibody Patient performance polymerase chain reaction positive Primary infection Prospective Study Quantitative reference standard Release respiratory response reverse transcription Reverse transcription-polymerase chain reaction SARS SARS-CoV-2 SARS-COV-2 infection sensitivity serological serological test Serological tests serology severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity severity of illness simple specificity subject subjects T T-cell T-cell Response uninfected vaccination was measured Whole blood with mild disease γ release assay. [DOI] 10.1093/cid/ciab1021 PMC 바로가기 [Article Type] Article
Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activityResearch article Published on 2022-08-242022-10-05 Journal: Molecular Therapy. Nucleic Acids [Category] 치료제, [키워드] acute respiratory syndrome antiviral activity antiviral response antiviral therapeutic antiviral therapeutics base base pairs blunt cell lines Characteristics coronavirus coronavirus disease COVID-19 described DNA double-stranded RNA dsRNAs groups highlight Hoogsteen G-G base pairing human lung IFN IFN-I IFN-III immunostimulant immunostimulatory immunostimulatory RNA independent induce Infection Influenza influenza A virus interferon lack lung MERS-CoV Middle East monophosphate motif MT: Oligonucleotides not affect organ on a chip pandemic pathophysiology pathway proinflammatory receptor respiratory syndrome coronavirus respiratory virus RIG-I RNA RNAs SARS-CoV SARS-CoV-2 SARS-COV-2 infection sequence siRNAs terminal hydroxyl Therapies and Applications TLR type I type III interferon unique [DOI] 10.1016/j.omtn.2022.08.031 [Article Type] Research article
Rapid Cytokine Release Assays for Analysis of Severe Acute Respiratory Syndrome Coronavirus 2-Specific T Cells in Whole Blood전혈에서 중증 급성 호흡기 증후군 코로나바이러스 2-특이적 T 세포 분석을 위한 신속한 사이토카인 방출 분석Article Published on 2022-08-242022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed anti-receptor-binding domain antibody Blood samples characteristic clinical complicate Complication controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine cytokine Cytokine release assay diagnosed Diagnosis Diagnostic accuracy Donor EudraCT evaluated exhibited high accuracy IgG IgG levels Immunoglobulin Immunoglobulin G induction Infection interferon interferon γ memory memory response nucleocapsid Patient peptide peptides plasma Previous studies protocol Rapid receiver receiver operating characteristic Region Release remained respiratory SARS-CoV-2 seropositive serum severe acute respiratory syndrome Coronavirus spike stimulated study participant supernatant T cells T-cell T-cell immunity Trial vaccine doses waned Whole blood [DOI] 10.1093/infdis/jiac005 PMC 바로가기 [Article Type] Article
Temporal Dynamics of Anti-Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019코로나바이러스 질병 2019 환자에서 항-유형 1 인터페론 자가항체의 시간적 역학Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 진단, [키워드] autoantibodies autoantibody binding convalescence. coronavirus disease COVID-19 Critical Dynamics identifying IFN-α IFN-ω Immunoglobulin in healthy individual interferon Most patient neutralization activity neutralize peaked Temporal type 1 interferon viral disease [DOI] 10.1093/cid/ciab1002 PMC 바로가기 [Article Type] Article
Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries Research Published on 2022-08-192022-10-05 Journal: Nature biomedical engineering [Category] 임상, 치료기술, 치료법, [키워드] addition Analysis autoantibody autoreactive antibody can be used circulating convalescent plasma COVID-19 detect DNA expressed facilitate FIVE full-length protein healthy IFN IFN-α individuals with COVID-19 interactions interferon life-threatening life-threatening coronavirus disease Neutralizing ORFeome Patient plasma plasma sample plasma samples Protein Sequencing severe COVID-19 unique [DOI] 10.1038/s41551-022-00925-y [Article Type] Research
Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19심각하거나 치명적인 COVID-19에 대한 숙주 유전자 변이 및 감수성의 임상적 의미Review Published on 2022-08-192022-09-11 Journal: Genome Medicine [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advanced age age allergy Asymptomatic disease clinical clinical implications Clinical management clinical picture Comorbidities convergence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical deficiency develop Effects expected Factor Genetic genetic finding genetic screening Genetic variant Genetic variation healthy individual heterogeneous Host host genetics human immune response IFN-I Immunity implication indicate Infectious disease interferon Male sex malignancies manifestation Mendelian disorder Mendelian disorders modulate pandemic pathogenic variant pathway Pathways Patient Pneumonia predisposition Prevalence rare variant Rare variants risk factor SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe manifestations of COVID-19 shown susceptibility susceptibility loci the interferon TLR7 virus X-linked [DOI] 10.1186/s13073-022-01100-3 PMC 바로가기 [Article Type] Review
Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport Research Published on 2022-08-152022-10-05 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료제, [키워드] accessory protein Acidic addition antagonistic antagonists binding blockade C-terminal cells Community complex crystal structure expression hydrophobic identify immunosuppressive in vitro Interaction interferon interferon antagonism International methionine molecular basis mRNA Mutagenesis mutated Mutation ORF6 Orf9b peptide residue reveal salt-bridge SARS-CoV SARS-CoV-2 SARS-CoV-2 variant Stat1 the binding affinity the spike protein Transport VOCs [DOI] 10.1038/s41467-022-32489-5 [Article Type] Research
Papain-like protease of SARS-CoV-2 inhibits RLR signaling in a deubiquitination-dependent and deubiquitination-independent mannerArticle Published on 2022-08-122022-10-06 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] acute respiratory syndrome antiviral therapy attenuate catalytic component components contribute Coronavirus-2 COVID-19 Critical cysteine demonstrated Deubiquitination disease severity domain DUB dysregulated Effect Efficiency exhibited greater IFN IFN response independent inhibit inhibitory activity inhibitory effect innate immune interferon IRF3 IκBα MAVS mechanism mechanisms mutant Papain-like protease PLPro protease receptor reduced reported required residue response responses RIG-I RLR signaling SARS-CoV SARS-CoV-2 SARS-CoV-2 pathogenesis Sendai virus Signal transduction Signaling signaling pathway significantly specificity suppressed target TBK1 TRAF3 Traf6 [DOI] 10.3389/fimmu.2022.947272 PMC 바로가기 [Article Type] Article
Commercialized kits to assess T-cell responses against SARS-CoV-2 S peptides. A pilot study in health care workersSARS-CoV-2 S 펩타이드에 대한 T 세포 반응을 평가하기 위한 상용화된 키트. 의료 종사자를 대상으로 한 파일럿 연구Article Published on 2022-08-122022-09-11 Journal: Medicina clínica [Category] SARS, 진단, 치료기술, [키워드] antibody Antibody test antibody tests Automation BNT162b2-mRNA-COVID-19-vaccine Cell mediated immunity CLIA complement Concordance correlation COVID-19 detect dose ELISA English Ensayos de liberación Interferon-gamma feasibility first vaccination group groups HCW Health care worker IFNγ immune response Immunosuppressed individual Infection Inmunidad Mediada por Células interferon Interferon-gamma-release-assays mRNA natural infection number of sample number of samples peptides pilot study positive Quantitative ranged risk S-protein SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 S SARS-CoV-2 vaccines Sensitivity and specificity Spanish susceptible T-cell Response T-cell responses vaccine dose Vacuna BNT162b2-mRNA-COVID-19. [DOI] 10.1016/j.medcli.2021.09.013 PMC 바로가기 [Article Type] Article