Longitudinal relationship of liver injury with inflammation biomarkers in COVID-19 hospitalized patients using a joint modeling approach공동 모델링 접근법을 사용하는 COVID-19 입원 환자의 염증 바이오마커와 간 손상의 종단 관계Article Published on 2022-04-012022-09-11 Journal: Scientific Reports [Category] 바이오마커, 치료법, 치료제, [키워드] age Alanine Alanine transaminase alkaline phosphatase ALT approach aspartate Aspartate transaminase AST Biomarker blood lymphocyte count C-reactive protein change consecutive patient correlated correlation COVID-19 COVID-19 infection CRP D-dimer decrease died evaluate Generalized hospital Hospitalization hospitalized patient Inflammation inflammation marker inflammation markers interleukin interleukin-6 joint Liver damage Liver disease Liver injury longitudinal lymphocyte Lymphocyte count marker mechanism negative correlation Patient patients with COVID-19 phosphatase plasma positive serum serum C-reactive protein Sex Spain statistical survival Survivors systemic inflammation the patient therapy was used were used [DOI] 10.1038/s41598-022-09290-x PMC 바로가기 [Article Type] Article
Low testosterone predicts hypoxemic respiratory insufficiency and mortality in patients with COVID-19 disease: another piece in the COVID puzzle낮은 테스토스테론은 COVID-19 질병 환자의 저산소성 호흡 부전 및 사망률을 예측합니다: COVID 퍼즐의 또 다른 조각Article Published on 2022-04-012022-09-11 Journal: Journal of Endocrinological Investigation [Category] 바이오마커, [키워드] 95% CI 95% confidence interval acute illness acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age association C-reactive protein clinical impact Comorbidities coronavirus coronavirus disease COVID COVID-19 described evaluate evaluated ferritin fraction Hospital stay Hospitalized hypogonadism hypoxemic in-hospital mortality Infection Inflammation inflammatory parameter inflammatory parameters interleukin-6 investigated IRCCS Italy Lactate lactate dehydrogenase male male subject male subjects Mortality mortality rate multivariable Odds ratio Older outcome oxygen P/F ratio PaO partial pressure patients with COVID-19 Pneumonia predict Prevalence Prospective Regression analyses respiratory respiratory insufficiency SARS-CoV-2 SARS-COV-2 infection serum severe acute respiratory syndrome Coronavirus significantly subject syndrome Testosterone thyroid function Ventilation [DOI] 10.1007/s40618-021-01700-7 PMC 바로가기 [Article Type] Article
Cardiac And Inflammatory Biomarkers And New Or Worsening Heart Failure In High-risk Patients With COVID-19Conference abstract Published on 2022-04-012022-10-05 Journal: Journal of cardiac failure [Category] 바이오마커, [키워드] adverse outcome age association average baseline biochemical marker BNP C-reactive protein cardiac Cardiomyopathy cell activation clinical collected condition consequence coronary syndrome COVID-19 Cytokines decrease defined develop Diagnosis discharge dysfunction Ejection fraction elevated enrolled failure Follow-up greater groups heart Hospital admission Hospitalized hsCRP identify IL-6 Immune cell Inflammation Inflammatory biomarker inflammatory biomarkers Inflammatory marker interleukin-6 interquartile range IQR Ischemia male management measure mechanism median multifactorial myocardial injury myocarditis New no significant difference Patient peptide performed plasma pro-inflammatory cytokine storm profile prospective cohort study quantification reported Result risk factor sensitivity serum specimen Subtypes syndrome Trigger troponin levels ventricular with COVID-19 worsening [DOI] 10.1016/j.cardfail.2022.03.243 [Article Type] Conference abstract
Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway Research Published on 2022-03-222022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] activate activated Activation Angiogenesis anti-IL6 antibody binding blocking Cell complications Consensus conserved Coverage COVID-19 patient Culture disease downstream Endothelial cell endothelial cells Ex vivo exhibited expression glycoprotein greater growth human lung IL-6 interleukin-6 liver Local Lrg1 observation pathogenic pathway Phosphorylation physiological condition produced promote promoted promoter receptor reduced resulting secreted significantly STAT3 stimulate therapy Transcription Treatment utility Vascular vessel [DOI] 10.1038/s41598-022-08516-2 [Article Type] Research
Baricitinib against severe COVID-19: effectiveness and safety in hospitalised pretreated patientsObservational Study Published on 2022-03-012022-10-04 Journal: European Journal of Hospital Pharmacy [Category] SARS, 임상, [키워드] activities Admission Adverse adverse event age Anti-inflammatory Baricitinib C-reactive protein clinical clinical benefit Clinical improvement Corticosteroid COVID-19 Critical Critical care Cytokine storm syndrome education Effectiveness event Evidence-based medicine ferritin hospital discharge hospitalised hospitalised patient immunomodulator improvement inhibitor interleukin-6 IQR laboratory parameter limitation Lymphocytes men Patient Pharmacy Platelet poor prognosis pulmonary medicine Randomised trial reported Retrospective study risk factor severe COVID-19 survival Time to recovery treated Treatment viral endocytosis Virology [DOI] 10.1136/ejhpharm-2021-002741 PMC 바로가기 [Article Type] Observational Study
Prognostic and Predictive Biomarkers in Patients With Coronavirus Disease 2019 Treated With Tocilizumab in a Randomized Controlled Trial무작위 대조 시험에서 토실리주맙으로 치료된 2019 코로나바이러스 질환 환자의 예후 및 예측 바이오마커Clinical Trial Published on 2022-03-012022-09-11 Journal: Critical Care Medicine [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] (interleukin-6 additional sensitivity analyses Analysis antibody assigned binomial Biomarker Biomarkers C-reactive protein candidate Clinical outcome clinical outcomes clinical status Controlled coronavirus disease Coronavirus disease 2019 COVACTA D-dimer death dimer double-blind Effect Europe evaluated Exploratory analysis ferritin ferritin level hospital discharge Hospitalized Interaction interleukin interleukin-6 Lactate lactate dehydrogenase Lymphocytes measurement mechanical ventilation modeling Monocytes Mortality multicenter Multiple Neutrophils North America observational study Ordinal Scale outcome Patient patients hospitalized phase 3 trial Placebo placebo-controlled Platelets Pneumonia Predictive Predictive value prognostic randomization Randomized Randomly receiving receptor retrospective seven-category ordinal scale severe coronavirus disease standard care Tocilizumab treatment with tocilizumab Trial were measured [DOI] 10.1097/CCM.0000000000005229 PMC 바로가기 [Article Type] Clinical Trial
Selenium and silver nanoparticles: A new approach for treatment of bacterial and viral hepatic infections via modulating oxidative stress and DNA fragmentationArticle Published on 2022-03-012023-06-11 Journal: Journal of biochemical and molecular toxicology [Category] B형 간염, [키워드] Hepatitis B virus interleukin-6 oxidative stress selenium nanoparticles Silver nanoparticles tumor necrosis factor-α [DOI] 10.1002/jbt.22972
A New Approach to the Management of COVID-19. Antagonists of IL-6: SiltuximabCOVID-19 관리에 대한 새로운 접근 방식. IL-6의 길항제: 실툭시맙Review Published on 2022-03-012022-09-12 Journal: Advances in therapy [Category] SARS, 진단, [키워드] administration antagonist caused Characteristics clinical evidence clinical study clinical trial conducted COVID-19 COVID-19 patient Cytokine release syndrome death downregulate drug drugs Effect effort IL-6 IL-6 level IL-6 levels inflammatory mediator inflammatory process information interleukin-6 International mechanism mechanism of action monoclonal antibodies monoclonal antibody National New overexpression pandemic pathway Patient patients patients with COVID-19 poor prognosis Prevent produced provided reducing Respiratory complications Respiratory disease SARS-COV-2 infection severe respiratory disease siltuximab Symptom therapeutic use Treatment [DOI] 10.1007/s12325-022-02042-3 PMC 바로가기 [Article Type] Review
Tocilizumab treatment in severe COVID-19: a multicenter retrospective study with matched controls중증 COVID-19에서의 토실리주맙 치료: 대조 대조군을 사용한 다기관 후향적 연구Multicenter Study Published on 2022-03-012022-09-11 Journal: Rheumatology International [Category] 진단, 치료제, [키워드] Activation acute respiratory distress acute respiratory distress syndrome Analysis anti-IL-6R approach ARDS Arm ARMS carried case-control study collected Control coronavirus coronavirus disease COVID-19 criteria Critical cytokine Cytokine storm death develop distress effective Efficacy evaluate feature ferritin Gender hospitalized COVID-19 patients IL-6 in some interleukin interleukin-6 Interleukin-6 (IL-6) intubation logistic regression models Macrophage macrophage activation syndrome multicenter Multiple no significant difference outcome parameters Patient patients Pneumonia Primary outcome procalcitonin progression provided reduced reduction in Regression model reported respiratory distress Respiratory distress syndrome retrospective retrospective cohort Retrospective study SAS severe disease shown significantly Standard of care study population subset syndrome Tocilizumab Treatment was reduced was used [DOI] 10.1007/s00296-021-04965-6 PMC 바로가기 [Article Type] Multicenter Study
Renal consequences of the novel coronavirus disease 2019 (COVID-19) and hydrogen sulfide as a potential therapy신종 코로나바이러스 감염증 2019(COVID-19) 및 잠재적 치료법으로서의 황화수소의 신장 결과Review Published on 2022-03-012022-09-11 Journal: Nitric oxide : biology and chemistry [Category] SARS, 바이오마커, 치료제, [키워드] Acute kidney injury addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) Anti-inflammatory antioxidant Antiviral antiviral agent Antiviral agents Cancer caused cells Chronic kidney disease clinical study condition consequence coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia Diabetic diabetic nephropathy dialysis enzyme exhibit expression facilitate global pandemic H(2)S donors humans hydrogen Hydrogen sulfide Hydrogen sulfide (H(2)S) increase interleukin-6 kidney Kidney disease kidney dysfunction Kidney injury kidney transplant manifestation Mortality nephropathy Novel coronavirus novel coronavirus disease patients Pneumonia potential therapy prevalent protease reduced renal Renal cancer Respiratory illness SARS-CoV-2 Serine serine 2 serum SULFIDE survivor therapeutic therapy transmembrane transmembrane protease serine 2 Treatment virus [DOI] 10.1016/j.niox.2022.01.002 PMC 바로가기 [Article Type] Review