Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations정밀 의학(TOPMed)을 위한 100,000개 이상의 NHLBI Trans-Omics 컨소시엄 전체 게놈 서열의 사용은 아프리카 및 히스패닉/라틴계 혼합 인구 집단에서 전가 품질 및 희귀 변이 연관성 검출 개선Research Article Published on 2019-12-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 1000 Genomes Project addition African allele Analysis Anemia approach association average blood cell complex complex diseases conducted demonstrated European Frequency genetic architecture Genetic studies genetic study genome coverage genome-wide association genome-wide genotyping genome-wide significant Genotype genotype data genotype imputation genotypes Haplotype Reference Consortium HBB HBB gene HCT hematocrit hematological hemoglobin highlight homozygous impair IMPROVE imputation increase in independent individual information Linkage disequilibrium low frequency MAF mapping Medicine minor allele frequency MOST NHLBI phase Population populations power Quantitative rare variant Rare variants reference panel replicated rescued sequence Sequencing sequencing data subsequent traits utility variant variants WBC White blood cell white blood cell count whole genome whole genome sequence Whole genome sequencing [DOI] 10.1371/journal.pgen.1008500 PMC 바로가기 [Article Type] Research Article
Protocol, rationale and design of PEOPLE (Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar): a cluster randomized trial on effectiveness of different modalities of implementation of post-exposure prophylaxis of leprosy contactsPEOPLE(코모로와 마다가스카르에서의 한센병 노출 후 예방 조치): 한센병 접촉자에 대한 노출 후 예방 조치의 다양한 시행 방식의 효과에 대한 집단 무작위 시험의 프로토콜, 근거 및 설계Study Protocol Published on 2019-12-052024-08-01 Journal: BMC Infectious Diseases [Category] 한센병, [키워드] acceptability Clustering cost-effectiveness mapping Post exposure prophylaxis Single dose rifampicin [DOI] 10.1186/s12879-019-4649-0 PMC 바로가기 [Article Type] Study Protocol
Clustering of leprosy beyond the household level in a highly endemic setting on the Comoros, an observational study코모로의 고유행 지역에서 가정 수준을 넘어 한센병의 군집화, 관찰 연구Research Article Published on 2019-06-072024-08-01 Journal: BMC Infectious Diseases [Category] 한센병, [키워드] Clustering leprosy mapping Post-exposure prophylaxis Single dose rifampicin Transmission [DOI] 10.1186/s12879-019-4116-y PMC 바로가기 [Article Type] Research Article
Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions플라스모디움 팔시파룸 말라리아 전파의 계절적 변동이 pfhrp2 유전자 결실 감시에 미치는 영향Article Published on 2019-05-022024-08-11 Journal: eLife [Category] 말라리아, [키워드] mapping Mathematical modelling P. falciparum pfhrp2-deletion radid diagnostic tests [DOI] 10.7554/eLife.40339 PMC 바로가기
Expression estimation and eQTL mapping for HLA genes with a personalized pipeline개인화된 파이프라인으로 HLA 유전자에 대한 발현 추정 및 eQTL 매핑Research Article Published on 2019-04-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Human Leukocyte Antigens abundance adaptive aligned allele antibody applied approach approaches balancing selection biases carried Causality cause choice classical HLA loci dataset datasets develop difficulty disease disease phenotype disease susceptibility Diseases Divergence downstream analyses downstream analysis DPA1 DPB1 DQA1 DQB1 DRB1 eQTL eQTL mapping eQTLs estimate estimates evaluate explain expressed expression expression level expression levels Gene Expression Genotype genotypes help HLA HLA allele HLA alleles HLA gene HLA genes HLA region HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA HLA-DRB1 Human Leukocyte Antigens immune immune adaptive response influence information leukocyte Lineage lineages loci mapping nine organism P-value p-values paralogues phenotype Phenotypes predisposition problem qPCR quantification reference genome Regulation Regulatory remained RNA RNA-Seq sequence susceptibility target Transcriptome Variation [DOI] 10.1371/journal.pgen.1008091 PMC 바로가기 [Article Type] Research Article
Geostatistical analysis and mapping of malaria risk in children under 5 using point-referenced prevalence data in Ghana가나에서 점 참조 유병률 데이터를 사용한 5세 이하 아동의 말라리아 위험에 대한 지리통계 분석 및 지도화Research Published on 2019-03-112024-08-11 Journal: Malaria Journal [Category] 말라리아, [키워드] Exceedance probability Geostatistics hotspot malaria mapping [DOI] 10.1186/s12936-019-2709-y PMC 바로가기 [Article Type] Research
Spatial epidemiological approaches to inform leptospirosis surveillance and control: A systematic review and critical appraisal of methodsArticle Published on 2019-03-012023-06-22 Journal: Zoonoses and Public Health [Category] 조류인플루엔자, [키워드] ecoepidemiology environmental epidemiology Geostatistics GIS leptospirosis mapping modelling one health [DOI] 10.1111/zph.12549
Small-area spatial statistical analysis of malaria clusters and hotspots in Cameroon;2000–2015카메룬의 말라리아 집단 및 핫스팟에 대한 소규모 공간 통계 분석; 2000–2015Research Article Published on 2018-12-072024-08-11 Journal: BMC Infectious Diseases [Category] 말라리아, [키워드] Clusters Epidemiology Hotspots malaria mapping spatial statistics Urban-rural [DOI] 10.1186/s12879-018-3534-6 PMC 바로가기 [Article Type] Research Article
Mapping and Modelling Malaria Risk Areas Using Climate, Socio-Demographic and Clinical Variables in Chimoio, Mozambique기후, 사회 인구학적 및 임상 변수를 사용한 모잠비크 치모이오의 말라리아 위험 지역 매핑 및 모델링Article Published on 2018-04-192024-08-11 Journal: International Journal of Environmental Research and Public Health [Category] 말라리아, [키워드] malaria risk mapping modelling public precision health [DOI] 10.3390/ijerph15040795 PMC 바로가기 [Article Type] Article
Mapping occurrence of Taenia solium taeniosis/cysticercosis and areas at risk of porcine cysticercosis in Central America and the Caribbean basinResearch Published on 2017-09-182023-05-31 Journal: Parasites & Vectors [Category] Fulltext, 조류인플루엔자, [키워드] Taenia solium taeniosis/cysticercosis distribution mapping Neglected Tropical Disease Tapeworm [DOI] 10.1186/s13071-017-2362-7 PMC 바로가기 [Article Type] Research