mendelian randomization – Page 11 – Communicable Diseases Research

Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis

COVID-19 감수성 및 중증도에 대한 심혈관 대사 위험 요소: 멘델식 무작위 분석

Research Article

Published on 2021-03-042022-08-13
Journal: PLoS Medicine [Category] meta-analysis, SARS, 변종, 유전자 메커니즘, 진단, 치료제,

The effect of angiotensin-converting enzyme levels on COVID-19 susceptibility and severity: a Mendelian randomization study

COVID-19 감수성 및 중증도에 대한 지오텐신 전환 효소 수치의 영향: 멘델식 무작위 배정 연구

Article

Published on 2021-03-032022-09-11
Journal: International Journal of Epidemiology [Category] SARS, 변종,

[키워드] 95% CI 95% confidence interval ACE ACE gene ACE inhibitor ACE inhibitors Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme. benefit Cohort cohorts COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 severity COVID-19 susceptibility decrease European explain genetic determinant genetic determinants Genetic variant genetic variants Genome-wide association study GWAS Hospitalization Icelanders increase in individual inhibitor initiative Latino mendelian randomization observational studies Odds ratio outcome performed reducing SARS-COV-2 infection Sensitivity analyses serum severe disease severity susceptibility therapy These data Trial variance variant were used
[DOI] 10.1093/ije/dyaa229 PMC 바로가기 [Article Type] Article

Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection

심각한 SARS-CoV-2 감염 위험과 혈청 HDL-콜레스테롤 및 아포지단백 A1 수치의 연관성

Multicenter Study

Published on 2021-03-022022-09-10
Journal: Journal of Lipid Research [Category] 바이오마커, 변종,

[키워드] 95% CI, 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age allele alleles ApoA1, apolipoprotein A1 APOE4 apolipoprotein A1 association Biomarker CAD, coronary artery disease cholesterol clinical risk factor Clinical risk factors Coronary artery Coronary artery disease coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19, Coronavirus disease 2019 cumulative cumulative effects diabetes Effect elevated evaluated Evidence feature genetic risk score Genetic variant genetic variants GRS, genetic risk scores HDL-cholesterol higher risk homozygous hypertension ICD-10, International Classification of Diseases, Tenth Revision increase in individual Infection investigated Logistic regression analyses Logistic regression analysis mendelian randomization Mendelian randomization analyses Mendelian randomization analysis metabolic syndrome Mortality MR, Mendelian randomization MVMR, multivariate MR negative controls Novel coronavirus obesity OR, odds ratio outcomes PC, principal component reduced risk respiratory Respiratory disease risk SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 serum serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection severe respiratory disease severe SARS-CoV-2 severity of COVID-19 Sex susceptible syndrome type 2 diabetes UK biobank were used
[DOI] 10.1016/j.jlr.2021.100061 PMC 바로가기 [Article Type] Multicenter Study

Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity

특발성 폐섬유증과 COVID-19 중증도 사이의 유전적 병인 공유

Article

Published on 2021-03-012022-09-11
Journal: EBioMedicine [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

[키워드] airway airways Analysis association carriers causal variant characterized combined effect complex controls correlation COVID-19 COVID-19 hospitalization COVID-19 Host Genetics Initiative COVID-19 severity determine Effect estimate Evidence excluded explanation fibrosis foundation Genetic genetic association genetic determinant genetic etiology genetic risk factors genetic variants Genome-wide association study GWAS GWAS meta-analysis idiopathic Idiopathic pulmonary fibrosis increased risk initiative instrumental variable instrumental variables IPF Linkage disequilibrium lung Lung disease mendelian randomization MUC5B mucin Oak Older Older adults other variants outlier Patient performed Pneumonitis positive protective effect Protective effects provided pulmonary fibrosis risk allele risk factor risk loci risk of COVID-19 SARS-COV-2 infection scarring selection bia Selection bias Self-isolation severe COVID-19 severity survival susceptibility the strongest variance variant were used with COVID-19
[DOI] 10.1016/j.ebiom.2021.103277 PMC 바로가기 [Article Type] Article

A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

Research

Published on 2021-02-252022-10-05
Journal: Nature Medicine [Category] SARS, 신약개발, 유전자 메커니즘, 임상, 치료법, 치료제,

Impact of body composition on COVID-19 susceptibility and severity: A two-sample multivariable Mendelian randomization study

Article

Published on 2021-02-232023-06-15
Journal: Metabolism: clinical and experimental [Category] MERS, SARS,

[키워드] body composition Body fat distribution COVID-19 mendelian randomization obesity SARS-CoV-2
[DOI] 10.1016/j.metabol.2021.154732 PMC 바로가기

Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to severe SARS-CoV-2

심각한 SARS-CoV-2에 기여할 수 있는 순환 단백질에 대한 심혈관 대사 노출의 영향 평가

Research Paper

Published on 2021-02-032022-09-11
Journal: EBioMedicine [Category] MERS, 바이오마커, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody applied approach BMI body mass body mass index C-reactive protein cardiometabolic cardiometabolic exposure cardiometabolic risk factor Cardiometabolic risk factors caused circulating Circulating proteins conducted contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease COVID-19 progression COVID19 Critical cytokine Cytokines determine Developing disease Effect evaluate the effect Evaluating Evidence evidence of example finding foundation functions funding Future Genetic genomic location global pandemic glycoprotein heart help highlight host protein host response Immunoglobulin Immunoglobulin G independent Infection Inflammatory marker inflammatory markers Inflammatory response initial Innovation interleukin interleukin-6 involved IVW Medical Research Council mendelian randomization multiple testing Multivariable MR overcome Pathogenesis predicted progression proportion Protein provided raised receptor receptor antagonist replicate Research respiratory responsible risk risk factor Risk factors robust SARS-CoV-2 SARS-COV-2 infection sensitivity severe acute respiratory syndrome Coronavirus severe COVID-19 disease severe SARS severe SARS-CoV-2 smoking Standard deviation systemically the strongest Therapeutic strategies therapeutic strategy Triglyceride triglycerides turn variant variety Wellcome Trust
[DOI] 10.1016/j.ebiom.2021.103228 PMC 바로가기 [Article Type] Research Paper

Association of Serum Mannose With Acute Respiratory Distress Syndrome Risk and Survival

급성 호흡 곤란 증후군 위험 및 생존과 혈청 만노스의 연관성

Research

Published on 2021-01-272022-09-25
Journal: JAMA Network Open [Category] 바이오마커, 진단,

[키워드] 95% CI acute respiratory distress Admission age Analysis analyzed ARDS association Berlin criteria Biomarker Blood Boston center Chest Clinical diagnosis cohort study control group controls coronavirus disease criteria Critically ill Critically ill patient critically ill patients Deaconess defined diagnosed distress evaluate finding functional hazard ratio high mortality ICU ICUs identification Importance intensive care unit Intervention invasive male mannose Massachusetts Massachusetts General Hospital measure mendelian randomization metabolite Mortality objective Odds ratio outcome Oxygenation pandemic participant Participants patients with ARDS Point Prognosis prospective cohort Protective randomization recruited reduced regulated Relevance respiratory Result risk serum setting Study design suggested survival syndrome therapeutic ventilatory assistance was performed was used
[DOI] 10.1001/jamanetworkopen.2020.34569 PMC 바로가기 [Article Type] Research

Mendelian randomization analysis identified genes pleiotropically associated with the risk and prognosis of COVID-19

Mendelian randomization analysis는 COVID-19의 위험 및 예후와 다면적으로 관련된 유전자를 확인했습니다.

Article

Published on 2021-01-012022-09-11
Journal: The Journal of Infection [Category] Fulltext, SARS, 변종, 유전자 메커니즘,

[키워드] Analysis antiviral immunity applied association Blood Blood coagulation caused Coagulation coronavirus coronavirus disease Coronavirus disease 2019 correction COVID-19 cytokine Cytokine storm disease effective exhibited expression Gene expression quantitative trait loci Genes Genetic variant Genome-wide association study global pandemic hospitalized COVID-19 HPS5 identify IFNAR2 Inflammation Interpretation involved leads lung mechanism mendelian randomization multiple testing outcome pleiotropic PON2 potential therapeutic target potential therapeutic targets probe probes Prognosis Quantitative respiratory risk SMR Summary Mendelian randomization. susceptibility Treatment Variation Venous Thromboembolism with COVID-19
[DOI] 10.1016/j.jinf.2020.11.031 PMC 바로가기 [Article Type] Article

Genetic mechanisms of critical illness in COVID-19

Research

Published on 2020-12-012022-10-05
Journal: Nature [Category] 신약개발, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, 치료제,

[키워드] Antiviral association caused CCR2 chemotactic chromosome Clinical practice coronavirus disease COVID-19 Critical Critically ill patient dipeptidyl peptidase drugs ENCODE enzyme activator Evidence expression gene cluster Genetic Genetic variant Genome-wide association study genome-wide significant GenOMICC Host identify IFNAR2 Inflammatory intensive care units life-threatening low expression Lung inflammation lung tissue mechanism mendelian randomization OAS1 OAS2 organ damage randomized clinical trial receptor replicated robust severe COVID-19 target the interferon therapeutic transcriptome-wide Treatment TYK2 tyrosine with COVID-19
[DOI] 10.1038/s41586-020-03065-y [Article Type] Research