TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer Research Published on 2022-04-202022-10-05 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, [키워드] Affect bladder Bladder cancer cellular correlated dataset dysregulation functions Gene Expression gene silencing group involved mapped mechanism Messenger RNA Methylation Modification N1-methyladenosine over-expressed regulate regulatory element RNA RNA modification RNAs Small RNAs target transfer unfolded protein response [DOI] 10.1038/s41467-022-29790-8 [Article Type] Research
SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13기도 세포의 SARS-CoV-2 감염은 IL-13에 의해 영향을 받는 두 가지 확산 메커니즘인 강력한 바이러스 및 세포 방출을 유발합니다Article Published on 2022-04-192022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected airway airways Allergic asthma Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral Asthma asthmatic cause caused Cell Cell culture cell cultures cell tropism cells ciliated cell ciliated cells coronavirus COVID-19 COVID-19 severity down-regulated gene down-regulated genes electron microscopy enzyme epithelial epithelial cells examined expression gene expression analyses Gene Expression Omnibus Genes glycoprotein HAE high risk host–virus interaction human airway human airway epithelial human airway epithelial cells IL-13 IL-13 cytokine immunohistochemistry In situ hybridization infected cells Infection interferon interleukin interleukin-13 Intracellular involved keratan sulfate Lung disease mechanism Messenger RNA Microscopy MUC5AC mucin Mucus number of infected primary human airway reduced removal Replication RNA RNA-sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shedding shielding significantly Spread sulfate susceptibility Transmission Transport TRAP treated up-regulated viral egress viral entry Viral load Viral reservoir viral spread viral titers virions viruses were infected [DOI] 10.1073/pnas.2119680119 PMC 바로가기 [Article Type] Article
Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection바이러스성 호흡기 감염에서 박테리아를 구별하기 위한 신속한 숙주 유전자 발현 검사의 전향적 검증Multicenter Study Published on 2022-04-012022-09-11 Journal: JAMA Network Open [Category] 유전자 메커니즘, 진단, [키워드] 95% CI absence acute COVID-19 acute respiratory illness age Analysis antibacterial therapy antibiotic ARI Asian Bacterial Bacterial infection black Care cause Characteristics children clinical clinically Cohort Concordance diagnostic Emergency Departments enrolled Enrollment entire cohort Ethnicity expression febrile female followed by group groups Hispanic Host host gene host gene expression host response IMPROVE individual IQR less likelihood male median age Messenger RNA multicenter Native Negative predictive value NPV offer outcome outcomes participant Participants pathogen Patient patients with ARI patients with COVID-19 performance Positive predictive value Predictive value primary analysis Probability procalcitonin Prospective quantified Rapid reported respiratory Respiratory illness resulting sensitivity specificity stratified Test the median validation Viral viral infection white with COVID-19 [DOI] 10.1001/jamanetworkopen.2022.7299 PMC 바로가기 [Article Type] Multicenter Study
RNA therapy: rich history, various applications and unlimited future prospectsRNA 요법: 풍부한 역사, 다양한 응용 및 무한한 미래 전망Review Published on 2022-04-012022-09-11 Journal: Experimental & Molecular Medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] accumulated addition approved can not cells clinical study COVID-19 pandemic disease Diseases drug effective example expected groups human disease human diseases incurable mechanism Messenger RNA offer organ organs reference point Research researcher RNA therapeutic agent therapeutic agents therapy treated Treatment Vaccine variety [DOI] 10.1038/s12276-022-00757-5 PMC 바로가기 [Article Type] Review
Comparative analyses of IgG/IgA neutralizing effects induced by three COVID-19 vaccines against variants of concern3가지 COVID-19 백신이 우려하는 변이체에 대해 유도된 IgG/IgA 중화 효과의 비교 분석Article Published on 2022-04-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] (Alpha) (Beta) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition All participants Alpha Analysis analyzed anti-SARS-CoV-2 antibody Antibody titer Antibody titers B.1.1.7 B.1.351 B.1.617.2 Beta BNT162b2 ChAdOx1 circulating variant circulating variants Comparative convalescent convalescent individual convalescent individuals convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients COVID-19 vaccine Delta delta variant demonstrated E484K Efficacy heterogeneous highest IgA IgA antibodies IgA responses IgG IgG and IgA antibodies IgG response immunized in some individuals Messenger RNA mRNA mRNA-1273 mRNA-based vaccine neutralization neutralization ability neutralization capacity neutralization titer neutralize neutralizing capacity neutralizing effect of BNT162b2 patients positive Receptor binding domain recipients reported respiratory robust S1 IgG SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 WT serum serum sample serum samples severe acute respiratory syndrome Coronavirus specific antibodies Spike protein tested Vaccine Vaccines variant variants variants of concern virus Virus neutralization virus-specific antibodies was determined wild type WT virus [DOI] 10.1016/j.jaci.2022.01.013 PMC 바로가기 [Article Type] Article
Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals코로나바이러스 질병 2019 메신저 RNA 백신 면역억제된 개인의 면역원성Article Published on 2022-04-012022-09-11 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 19 vaccine 2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibody Antibody Response Antibody responses binding CD4 CD8 T-cell coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 COVID-19 mRNA Vaccination cross-reactivity function Immunocompromised immunocompromised individuals immunogenicity immunosuppressive increased mortality individual individuals Infection interferon interferon-γ lead messenger Messenger RNA mRNA mRNA vaccination mRNA vaccine Neutralizing reduce reduced regimen respiratory response RNA SARS SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus T cells therapy These data vaccine immunogenicity Viral viral clearance Viral variants [DOI] 10.1093/infdis/jiab569 PMC 바로가기 [Article Type] Article
Effectiveness of COVID-19 booster vaccines against COVID-19-related symptoms, hospitalization and death in England영국에서 COVID-19 관련 증상, 입원 및 사망에 대한 COVID-19 추가 백신의 효과Article Published on 2022-04-012022-09-11 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] Against all age group all age groups AstraZeneca BNT162b2 booster booster dose booster vaccination Booster vaccine Case-control ChAdOx1-S circulation coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19-related symptoms death delta variant dominant dose Effectiveness England Evidence evidence of Hospitalization individual Limited Messenger RNA Mild Moderna mRNA mRNA-1273 no evidence of of BNT162b2 offered Pfizer-BioNTech provide ranged second dose severe disease symptomatic symptomatic disease vaccination Vaccine [DOI] 10.1038/s41591-022-01699-1 PMC 바로가기 [Article Type] Article
Immunogenicity and safety after the third dose of BNT162b2 anti-SARS-CoV-2 vaccine in patients with solid tumors on active treatment: a prospective cohort study활성 치료 중인 고형 종양 환자에서 BNT162b2 항-SARS-CoV-2 백신 3차 접종 후 면역원성과 안전성: 전향적 코호트 연구Article Published on 2022-04-012022-09-11 Journal: ESMO open [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] active treatment acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration anti-SARS-CoV-2 antibody baseline BNT162b2 BNT162b2 anti-SARS-CoV-2 vaccine booster booster dose Cancer cancer patient Cancer patients cell-mediated immune cell-mediated immune response Concentration consecutive patient coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 infection Delta dose effective Efficacy enrolled evaluated Gamma humoral IgG IgG antibody immunogenicity Immunoglobulin Immunoglobulin G interferon interferon gamma interferon-γ interquartile range IQR median Messenger RNA naïve naïve subject naïve subjects neutralization Neutralizing neutralizing antibody of BNT162b2 omicron Patient patients Preliminary data primary endpoint prospective cohort study quantified reached recruited Release respiratory SARS-CoV-2 SARS-CoV-2 vaccine serum severe acute respiratory syndrome Coronavirus significantly higher solid cancer solid tumor subject subjects the median the SARS-CoV-2 third dose Treatment Trigger Vaccine variant variants variants of concern VOCs were used whole blood sample wild-type strain [DOI] 10.1016/j.esmoop.2022.100458 PMC 바로가기 [Article Type] Article
Humoral response to SARS-CoV-2 adenovirus vector vaccination (ChAdOx1 nCoV-19 [AZD1222]) in heart transplant recipients aged 18 to 70 years of age18~70세 심장 이식 환자의 SARS-CoV-2 아데노바이러스 벡터 백신 접종(ChAdOx1 nCoV-19[AZD1222])에 대한 체액 반응Article Published on 2022-04-012022-09-11 Journal: The Journal of heart and lung transplantation : th [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95% CI Adenovirus adenovirus vector vaccine adenovirus vector vaccines administration adverse event age antibody Antibody Response binding domain ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine chronic Chronic kidney disease CKD Concentration detectable develop domain dose enrolled fatigue female headache heart heart transplant help Humoral response immune response immunogenicity Immunosuppressed immunosuppressed patients injection site pain Kidney disease less Messenger RNA minor symptom minor symptoms mycophenolate nCoV organ Patient paucity of data PCR testing predict Prospective Study receive recent recipient recipients responses SARS-CoV-2 SARS-COV-2 infection serum analysis solid organ solid organ transplant SOT Spike protein suggested the spike protein to define vaccination Vaccine vaccine doses were recorded [DOI] 10.1016/j.healun.2022.01.005 PMC 바로가기 [Article Type] Article
Differential neutralizing antibody responses elicited by CoronaVac and BNT162b2 against SARS-CoV-2 Lambda in Chile Research Published on 2022-04-012022-10-05 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, [키워드] 1.26 Analysis antibody antigenic BNT162b2 Comparative convalescent plasma CoronaVac D614G Delta delta variant dominant Efficacy elicit elicited Faculty of Medicine First wave Gamma healthcare worker HEK293T-ACE2 cells Immune escape inactivated individual Lambda Local Messenger RNA Mutation N-terminal domain neutralization neutralization capacity neutralize neutralizing antibody Neutralizing antibody response neutralizing antibody titre pseudotyped Pseudotyped virus reduced replication SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants South Structure the receptor-binding domain the spike protein vaccination Vaccine variant variants Vero-E6 cell virus was reduced Wuhan-Hu-1 [DOI] 10.1038/s41564-022-01092-1 [Article Type] Research