T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells소아 다기관 염증 증후군(MIS-C)의 T 세포는 SARS-CoV-2 펩티드 및 수많은 바이러스 특이적 CD4-CD8- 이중 음성 T 세포에 대한 CD4+ T 도우미 반응이 우세합니다.Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation Antigen CD3+ CD4 CD4+ CD4− CD8− double-negative T cells CD8 CD8+ CD8+ T cell CD8+ T cells children classical CTL Cytotoxic T cell enrolled epitope Epitopes example Follow-up frequencies helper immunodominant epitopes initial IQR lymphopenia magnitude majority MIS-C Numerous pathogenic Patient peptide peptide pool peptide pools peptides physiological response Protein Proteins Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 spike SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells single subject subject subjects subpopulation T cell T cell receptor T cell receptor Vβ21.3 T cell response T cell responses T cells T helper TCRs virus [DOI] 10.3390/ijms23137219 PMC 바로가기 [Article Type] Article
Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications단핵구 anisocytosis는 심혈관 합병증이있는 어린이의 다기관 염증 증후군 동안 증가합니다Article Published on 2022-06-202022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI Accuracy Analysis anisocytosis blood count blood sample Blood samples Cardiac complications cardiovascular complication Care CBC Child children children with MIS-C clinically Cohort collected complete blood count complex COVID-19 creating develop diagnostic Diagnostic accuracy disease distribution effective enrolled greater healthy controls hematologic identify illnesses IMPROVE increase Inflammatory initial Laboratory Laboratory test life-threatening Medical care MIS-C monocyte Monocyte distribution width multisystem inflammatory syndrome in children New on children outcome parameters pediatric COVID-19 quantified required risk SARS-COV-2 infection sensitivity single medical center specificity subject syndrome tested threshold time-consuming Treatment utility validation cohort [DOI] 10.1186/s12879-022-07526-9 PMC 바로가기 [Article Type] Article
Up-regulated serum levels of interleukin (IL)-17A and IL-22 in Egyptian pediatric patients with COVID-19 and MIS-C: Relation to the disease outcomeCOVID-19 및 MIS-C가 있는 이집트 소아 환자의 인터루킨(IL)-17A 및 IL-22의 상향 조절된 혈청 수준: 질병 결과와의 관계Article Published on 2022-06-012022-09-11 Journal: Cytokine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] age ALT antimicrobial peptide antimicrobial peptides ARDS cellular children contribute COVID-19 CRP D-dimer died dimer elevated ELISA epithelial cell epithelial cells ferritin healthy control IL-17A IL-22 Increased infections Inflammatory Inflammatory marker inflammatory markers Interleukins LDH Level lymphopenia MIS-C MIS–C neutropenia neutrophilia not correlated outcome pathology Pathways Patient patients patients with COVID-19 patients with SARS-CoV-2 Pediatric patient peptides Protective relation Sample size SARS-CoV-2 serum serum ferritin level Serum level serum levels signaling pathways significantly higher stimulate syndrome synergistic synergistic action the disease thrombocytopenia up-regulated were measured with COVID-19 [DOI] 10.1016/j.cyto.2022.155870 PMC 바로가기 [Article Type] Article
Thymic Dysfunction and Atrophy in COVID-19 Disease Complicated by Inflammation, Malnutrition and CachexiaReview Published on 2022-06-012023-07-08 Journal: Nutrition and health [Category] COVID19(2023년), [키워드] COVID-19 lymphocytopenia micronutrients MIS-C protein-calorie malnutrition starvation thymic atrophy Zinc [DOI] 10.1177/02601060221083160 PMC 바로가기 [Article Type] Review
Surgical treatment of a spontaneous spinal epidural hematoma under antithrombotic treatment of a multisystem inflammatory syndrome in children associated with SARS-COV-2Case Reports Published on 2022-06-012023-07-06 Journal: Child's nervous system : ChNS : official journal o [Category] COVID19(2023년), [키워드] cervical spine Epidural hematoma MIS-C SARS-CoV-2 [DOI] 10.1007/s00381-021-05375-6 PMC 바로가기 [Article Type] Case Reports
[Reinfection by SARS-CoV-2 in a child with history of multisystem inflammatory syndrome: a case report]Case Reports Published on 2022-06-012023-07-09 Journal: Archivos argentinos de pediatría [Category] COVID19(2023년), [키워드] children COVID-19 MIS-C pediatric multisystem inflammatory disease COVID-19 related Reinfection [DOI] 10.5546/aap.2022.e147 [Article Type] Case Reports
Infliximab treatment for refractory COVID-19-associated multisystem inflammatory syndrome in a Japanese child일본 어린이의 불응성 COVID-19 관련 다기관 염증 증후군에 대한 Infliximab 치료Article Published on 2022-06-012022-09-12 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Administered Asia Aspirin children circulating ferritin clinical feature clinical phenotype Clinical symptoms Cohort coronavirus disease COVID-19 develop diagnosed East extreme genetic background heterogeneous Hyperferritinemia hyperinflammation Immunopathogenesis immunopathology IMPROVE incidence induce Inflammation Inflammatory infliximab initial Intervention Intravenous immunoglobulin Japan Japanese Kawasaki disease lymphopenia MIS-C multisystem inflammatory syndrome in children onset of fever outcome Pathogenesis Patient Prednisolone Region reported required Symptom syndrome Therapies therapy treated Treatment treatment strategy tumor necrosis factor-α [DOI] 10.1016/j.jiac.2022.01.011 PMC 바로가기 [Article Type] Article
Multisystem Inflammatory Syndrome in an Adolescent Following SARS-CoV-2 Exposure Despite Three Doses of a COVID-19 VaccineCase Reports Published on 2022-06-012023-07-09 Journal: Rhode Island medical journal (2013) [Category] COVID19(2023년), [키워드] COVID-19 MIS-C multisystem inflammatory syndrome in children omicron SARS-CoV-2 [Article Type] Case Reports
Multisystem inflammatory syndrome in children associated with COVID-19 in 101 cases from Turkey (Turk-MISC study)터키에서 발생한 101명의 사례에서 COVID-19와 관련된 어린이의 다기관 염증 증후군(Turk-MISC 연구)Article Published on 2022-06-012022-09-12 Journal: Journal of paediatrics and child health [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Admission age Analysis body mass index C-reactive protein Child children classical clinical Clinical features clinician collected conducted COVID-19 death diagnosed Diagnosis died differential diagnosis elevated erythrocyte sedimentation rate fatigue Fever Gastrointestinal symptom Gender glucocorticoid groups healthy hospital immunomodulatory Inflammatory intensive care interquartile range Intravenous immunoglobulin IQR Kawasaki disease laboratory characteristics management median median age medical record MIS-C Most patient multivariate logistic regression outcome Patient patients PCR polymerase chain positive positive serology predominant procalcitonin level required Retrospective study SARS-CoV-2 Shock syndrome treated Treatment Turkey with COVID-19 [DOI] 10.1111/jpc.15913 PMC 바로가기 [Article Type] Article
COVID-19 in ChildrenReview Published on 2022-06-012023-07-09 Journal: Pediatric Clinics of North America [Category] COVID19(2023년), [키워드] ARDS COVID-19 Epidemiology MIS-C Pediatric COVID Risk factors SARS-CoV-2 [DOI] 10.1016/j.pcl.2022.01.013 PMC 바로가기 [Article Type] Review