Colorimetric RT-LAMP SARS-CoV-2 diagnostic sensitivity relies on color interpretation and viral load비색 RT-LAMP SARS-CoV-2 진단 감도는 색상 해석 및 바이러스 부하에 의존Article Published on 2021-04-272022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, [키워드] absorbance amplification can not clinical sample clinical samples Cluster color change COVID-19 defined demonstrated diagnose diagnostic False positives individual Interpretation isothermal amplification majority manuscript Molecular biology Molecular medicine naked eye nonspecific orange performed point-of-care positive positive sample reaction reaction time repeated respiratory respiratory virus respiratory viruses reverse transcriptase RNA virus RT-LAMP RT-qPCR RT-qPCR test SARS-CoV-2 sensitivity tested Viral viral infection Viral load viral loads viruses yellow [DOI] 10.1038/s41598-021-88506-y PMC 바로가기 [Article Type] Article
Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progressionArticle Published on 2021-04-082023-06-03 Journal: Scientific Reports [Category] B형 간염, [키워드] Clinical genetics Genotype haplotypes Infectious diseases Medical genetics Molecular medicine [DOI] 10.1038/s41598-021-87537-9 PMC 바로가기 [Article Type] Article
Lead compounds for the development of SARS-CoV-2 3CL protease inhibitorsSARS-CoV-2 3CL 프로테아제 억제제 개발을 위한 리드 화합물Article Published on 2021-04-012022-09-10 Journal: Nature Communications [Category] SARS, 신약개발, [키워드] 3CL complex Compound compounds crystal structures drug target effective identify in vitro inhibitor inhibitors leads Molecular medicine protease Protease inhibitor protease inhibitors SARS-CoV-2 Structure structures the SARS-CoV-2 these compound these compounds Virology X-ray crystallography [DOI] 10.1038/s41467-021-22362-2 PMC 바로가기 [Article Type] Article
Newly synthesized M pro inhibitors as potential oral anti-SARS-CoV-2 agents잠재적인 경구용 항SARS-CoV-2 제제로서 새로 합성된 M pro 억제제Comment Published on 2021-03-312022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 치료제, [키워드] anti-SARS-CoV-2 inhibitor M pro Molecular medicine Target validation [DOI] 10.1038/s41392-021-00560-0 PMC 바로가기 [Article Type] Comment
Identification and in vitro antifungal susceptibility of causative agents of onychomycosis due to Aspergillus species in Mashhad, Iran이란 마슈하드에서 아스페르길루스 종에 의한 손발톱 진균증의 원인균 식별 및 시험관 내 항진균 감수성Article Published on 2021-03-242024-07-28 Journal: Scientific Reports [Category] 백선증, [키워드] Diseases Evolution Microbiology Molecular biology Molecular medicine [DOI] 10.1038/s41598-021-86038-z PMC 바로가기 [Article Type] Article
Computational evidence for nitro derivatives of quinoline and quinoline N-oxide as low-cost alternative for the treatment of SARS-CoV-2 infectionArticle Published on 2021-03-182022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] Chemistry Compound compounds Computational biology and bioinformatics contagious coronavirus deaths derivative docking drugs Evidence help Infection isomer Medical research molecular molecular function Molecular medicine pandemic physicochemical property SARS-CoV-2 SARS-COV-2 infection Spread Symptoms the WHO therapeutic option transmission rate Treatment [DOI] 10.1038/s41598-021-85280-9 PMC 바로가기 [Article Type] Article
The in-vitro effect of famotidine on sars-cov-2 proteases and virus replicationArticle Published on 2021-03-082022-10-04 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] 3CL pro Administered analyzed antiviral activity antiviral drug approved assays bind cell lines clinical study Concentration coronavirus cough COVID-19 COVID-19 pandemic direct-acting Drug discovery function High dose hospitalized COVID-19 patients human cell improvement in silico In-vitro inhibit inhibitor intubation lack Lungs Medicine Mild moderate molecular mechanism Molecular medicine Mortality potential molecular protease Proteases reduced retrospective SARS-CoV-2 SARS-CoV-2 replication Shortness of breath Symptom target tested Treatment virus replication while [DOI] 10.1038/s41598-021-84782-w PMC 바로가기 [Article Type] Article
In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP)Plasmodium falciparum circumsporozoite protein (CSP)에 대한 단클론 항체에 의한 말라리아 기생충 감염의 시험관 내 및 생체 내 억제Article Published on 2021-03-052024-08-08 Journal: Burma Med J [Category] 말라리아, [키워드] Diseases immunology Microbiology Molecular medicine structural biology [DOI] 10.1038/s41598-021-84622-x PMC 바로가기 [Article Type] Article
Therapeutic potential of C1632 by inhibition of SARS-CoV-2 replication and viral-induced inflammation through upregulating let-7Letter Published on 2021-02-222022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, Fulltext, MERS, [키워드] Infectious diseases Inflammation Molecular medicine Replication SARS-CoV-2 upregulating viral-induced [DOI] 10.1038/s41392-021-00497-4 PMC 바로가기 [Article Type] Letter
Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19Article Published on 2021-02-032022-10-04 Journal: Scientific Reports [Category] MERS, 치료제, [키워드] acute respiratory syndrome Affect alarmin Analysis approach Biochemistry biogenesis Biotechnology carried caused Cell cellular pathway characterized complementary coronavirus Coronavirus disease 2019 Coronavirus replication correlated COVID-19 COVID-19 disease COVID-19 patient Critical cytokine Disease progression Diseases identify IL-17 Inflammation intensive care involved key factor Lipid lipid metabolism Mild moderate modulate Molecular medicine Pathogenesis pathway patients with COVID-19 profiles progression Proinflammatory cytokine SARS-CoV-2 SARS-CoV-2 infections serum severe symptom severity Spread therapeutic targets TSLP Vesicle virus virus entry virus propagation were measured [DOI] 10.1038/s41598-021-82426-7 PMC 바로가기 [Article Type] Article