ACE2 : S1 RBD Interaction-Targeted Peptides and Small Molecules as Potential COVID-19 TherapeuticsResearch Article Published on 2021-11-022022-10-28 Journal: Advances in Pharmacological and Pharmaceutical Sciences [Category] COVID-19, [키워드] ACE2 angiotensin-converting enzyme-2 antibody antigenic approved arising binding candidate Cell cellular receptor complement Contact COVID-19 COVID-19 pandemic Critical evaluated individual inhibiting inhibitor initiate Interaction interfere Invasion Modification molecule motif pandemic peptide Potential Prevent Protein RBD S1 RBD SARS-CoV SARS-CoV-2 SARS-CoV-2 entry shown small molecule specificity spike Spread the receptor-binding domain the vaccine therapeutic intervention Therapeutics therapy Vaccine viral entry [DOI] 10.1155/2021/1828792 PMC 바로가기 [Article Type] Research Article
Effect of mutation on structure, function and dynamics of receptor binding domain of human SARS-CoV-2 with host cell receptor ACE2: a molecular dynamics simulations study돌연변이가 숙주 세포 수용체 ACE2와 인간 SARS-CoV-2의 수용체 결합 도메인의 구조, 기능 및 역학에 미치는 영향: 분자 역학 시뮬레이션 연구Article Published on 2021-11-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 변종, [키워드] 6M0J ACE2 ACE2-RBD Affect Alanine alanine mutant alanine mutants Analysis angiotensin angiotensin-converting enzyme-II binding binding affinity cellular protease cellular proteases complex complexes conserved coronavirus Critical Directed mutagenesis disease severity drug Effect entry of SARS-CoV-2 enzyme exhibit FIVE flexible host cell host cell receptor human ACE2 human SARS-CoV-2 hydrogen Infection information inhibitor initiate Interface residues intermolecular hydrogen bond MD simulation MD simulations molecular molecular dynamics Molecular dynamics simulation molecular interaction motif Mutagenesis mutant Mutation priming Principal component provide RBD RBM recent Receptor binding Receptor binding domain receptor binding motif receptor binding motif. Receptor-binding domain Replication rate residue residues SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD Spike protein supported the binding affinity the receptor-binding domain viral spike protein ward wild-type [DOI] 10.1080/07391102.2020.1802348 PMC 바로가기 [Article Type] Article
Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfacesArticle Published on 2021-10-292022-10-31 Journal: Communications Biology [Category] COVID-19, MERS, SARS, [키워드] binding affinity Circular Contact de novo demonstrated domain domains inefficient Interaction motif Nanobiotechnology Particle Protein protein sequence Proteins Receptor binding domain repeated SARS CoV-2 significantly stability structures subunit subunits Topology trimeric viral neutralization X-ray crystallography [DOI] 10.1038/s42003-021-02766-y PMC 바로가기 [Article Type] Article
Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico StudyArticle Published on 2021-10-272022-10-28 Journal: Biomolecules [Category] COVID-19, MERS, [키워드] Affect Amino acid antagonist antigen-presenting cell article Asn343 binding carbohydrate recognition mechanism core COVID-19 Critical Cytokine storm DC-SIGN described determine epitope Epitopes expressed glycan glycan epitopes glycoprotein glycoside Glycosides higher affinity in silico Infection mechanism medication Molecular dynamics simulation molecular dynamics simulations monosaccharides motif natural glycoside antagonists offer oligosaccharide oligosaccharides physiological functions post-translational modification Potential predicted Protein recognize reported SARS-CoV-2 sequence spike suggested the SARS-CoV-2 Treatment variety [DOI] 10.3390/biom11111586 PMC 바로가기 [Article Type] Article
S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategiesResearch Article Published on 2021-10-252022-10-29 Journal: PLoS Pathogens [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Antiviral antiviral activity assist association binding broad inhibitor C-terminal C-terminal region catalytic site catalytically caused cofactor complex coronavirus CpG cysteine cytoplasm Degradation dependent on determinant dinucleotide distribution domain element Endoplasmic reticulum Factors highlight HIV-1 Human immunodeficiency virus hydrophobic in viral inactive Interaction isoform KHNYN lack membrane membranes Microscopy modulate motif N-terminal RNA-binding domain nucleus PARP physical plasma membrane polymerase post-translational modification Prevent Protein provide recruitment regulate replicate Replication required residue restored RNA RNA virus RNAs SARS-CoV-2 Structure subcellular translation TRIM25 type I Vesicle viral pathogens Viral RNA virion virus virus replication ZAP [DOI] 10.1371/journal.ppat.1009726 PMC 바로가기 [Article Type] Research Article
Direct RNA Sequencing Reveals SARS-CoV-2 m6A Sites and Possible Differential DRACH Motif Methylation among Variants직접 RNA 시퀀싱은 SARS-COV-2 M6A 부위 및 변이체간에 가능한 차등 DRACH 모티프 메틸화를 나타냅니다.Communication Published on 2021-10-202022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, [키워드] Affect base bases Beta causative agent complementary conserved COVID-19 COVID-19 pandemic Direct Direct RNA sequencing distribution dNTP dNTPs Epitranscriptomics Eta Genome genomes sequenced immune response implicated incorporation initial m6A methylated Methylation modifications motif ORF N ORF10 ORF3a ORF6 ORF7a ORF7b ORF8 positive-sense single-stranded RNA reduce residue reverse transcribed RNA RNA methylation RNAs SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 sequences SARS-CoV-2 variants sequence Site the SARS-CoV-2 the SARS-CoV-2 genome variant variants Viral viral genome viral genomes [DOI] 10.3390/v13112108 PMC 바로가기 [Article Type] Communication
Targeting the coronavirus nucleocapsid protein through GSK-3 inhibitionGSK-3 억제를 통한 코로나바이러스 뉴클레오캡시드 단백질 표적화Multicenter Study Published on 2021-10-192022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 진단, 치료법, [키워드] acute respiratory syndrome Analysis Antiviral approach Betacoronavirus block Clinical data conducted consensus sequence consensus sequences conserved coronavirus Coronavirus infection Coronavirus infections Coronaviruses COVID-19 COVID-19 in patient COVID19 Epidemics epithelial cells Express glycogen glycogen synthase GSK-3 GSK3A GSK3B health system Healthcare systems human lung human lung epithelial cells impair inhibitor inhibitors knockout less lithium lithium use lung epithelial cell Middle East Middle East respiratory syndrome Middle East respiratory syndrome-CoV motif N protein nucleocapsid nucleocapsid protein Odds ratio Outbreaks Patient personal health phosphorylated Phosphorylation raising reduced risk Replication required respiratory responsible Retrospective analysis SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 N protein Severe acute respiratory syndrome Significance significantly targeting the SARS-CoV-2 therapy Transcription treat Viral viral replication viral transcription virion assembly [DOI] 10.1073/pnas.2113401118 PMC 바로가기 [Article Type] Multicenter Study
Evolution, Interspecies Transmission, and Zoonotic Significance of Animal CoronavirusesVeterinary Science Published on 2021-10-182022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] accessory proteins Affect animal Animal coronaviruses classification coronavirus Evolution explain Factor gastrointestinal tract genome organization groups help highlight host cell receptor Human infecting interspecies transmission mammal motif mutate outcomes Pandemics protein binding motif rodent sequence Significance single-stranded RNA virus These viruses tissue tissues Transmission variants of concern variety wild animals zoonotic zoonotic animal origin [DOI] 10.3389/fvets.2021.719834 PMC 바로가기 [Article Type] Veterinary Science
Mutation-induced changes in the receptor-binding interface of the SARS-CoV-2 Delta variant B.1.617.2 and implications for immune evasionSARS-CoV-2 Delta 변이체 B.1.617.2의 수용체 결합 계면에서 돌연변이 유발 변화 및 면역 회피에 대한 의미Article Published on 2021-10-152022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 receptor Alpha Antibody binding B.1.1.7 B.1.351 B.1.617.2 Beta binding caused change changes in Delta delta variant Delta variant B.1.617.2 Effect Epitopes exhibited Health immune Immune escape immune evasion immune system implication in some Infection initial investigated less mechanism molecular dynamics motif Mutation Neutralizing antibodies neutralizing antibody offer pandemic provide reduced SARS-CoV-2 variants Spike protein the SARS-CoV-2 Vaccine variant variants variants of concern [DOI] 10.1016/j.bbrc.2021.08.036 PMC 바로가기 [Article Type] Article
Integrin activation is an essential component of SARS-CoV-2 infection인테그린 활성화는 SARS-COV-2 감염의 필수 구성 요소입니다Article Published on 2021-10-142022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 Activation angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antagonist basal state bind binding Cell adhesion Cell Biology cell entry confocal microscopy cytoplasmic tail Diseases downstream engage Engagement ENhance enzyme expresse extension flow cytometry inactive induce Infection Infectious diseases inhibit inhibited integrin Integrins ligands macromolecular mechanism membrane motif occur Particle peptide Peptide inhibitor Protein receptors rhodamine rhodamine B S protein SARS-CoV-2 SARS-COV-2 infection Signaling subunit viral infection [DOI] 10.1038/s41598-021-99893-7 PMC 바로가기 [Article Type] Article