Comparative Immunomodulatory Evaluation of the Receptor Binding Domain of the SARS-CoV-2 Spike Protein; a Potential Vaccine Candidate Which Imparts Potent Humoral and Th1 Type Immune Response in a Mouse ModelImmunology Published on 2021-05-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] biochemically candidate cells characterized Comparative Cytotoxic T cells driving generate glycosylation site humoral immune response immunization immunogenicity immunomodulation immunomodulatory effect Interaction investigated mice Model mouse neutralizing antibody neutralizing epitope potent Potential Protein RBD Receptor binding domain response robust SARS-CoV2 specificity spike Spike protein subunit Support T cell Th1 the SARS-CoV-2 the spike protein thermal stability Type unmet need vaccination Vaccine vaccine candidate Vaccine development viral entry [DOI] 10.3389/fimmu.2021.641447 PMC 바로가기 [Article Type] Immunology
Noninvasive Measurement of Pulmonary Function in Experimental Mouse Models of Airway Disease기도 질환의 실험적 마우스 모델에서 폐 기능의 비침습적 측정Review Published on 2021-05-192022-09-12 Journal: Lung [Category] MERS, SARS, 진단, [키워드] airway Airway hyperresponsiveness allergic Allergic asthma animal models Asthma Compliance conscious disease function gold standard human airway in vivo include invasive Laboratory lung Lung function lung mechanics marker measurement mice Model mouse mouse model noninvasive parameter Pathogenesis performed provide provided pulmonary Pulmonary function Pulmonary function testing repeated required Research respiratory infection respiratory parameter SARS-CoV-2 sensitivity translational validation study [DOI] 10.1007/s00408-021-00443-9 PMC 바로가기 [Article Type] Review
Cross-tissue organization of the fibroblast lineage Research Published on 2021-05-122022-10-05 Journal: Nature [Category] 진단, [키워드] activated Analysis approach Arthritis Autoimmunity Cancer Cell conserved datasets described disease fibroblast fibrosis Health healthy heterogeneity homeostasis humans Inflammation lack Lineage mice mouse organs pathogenicity phenotype recent single-cell subtype Support these cell tissue tissues transcriptional transcriptomic data transcriptomics [DOI] 10.1038/s41586-021-03549-5 [Article Type] Research
Antiviral and Anti‐Inflammatory Treatment with Multifunctional Alveolar Macrophage‐Like Nanoparticles in a Surrogate Mouse Model of COVID‐19Full Paper Published on 2021-05-122022-10-28 Journal: Advanced Science [Category] COVID-19, [키워드] acting aggregation‐induced emission derivative alveolar Antiviral antiviral efficiency applied biomimetic nanoparticles caused clinical clinically coronavirus coronavirus disease COVID‐19 COVID‐19 cytokine cytokine absorption cytokine levels decrease early stage ENhance facilitate host cell inactivation Infection Inflammation lung damage Macrophage management Medicine membranes mice Model mouse multifunctional multimodal therapy murine nanoparticle neutralization pandemic photothermal inactivation progression Proinflammatory cytokine proinflammatory cytokines receptor receptors reduce reducing regimen regimens reported respiratory tract risk significant survival advantage surface receptor surrogate therapeutic therapeutic strategy Transmission Treatment virus worsening [DOI] 10.1002/advs.202003556 PMC 바로가기 [Article Type] Full Paper
Genome sequence, transcriptome, and annotation of rodent malaria parasite Plasmodium yoelii nigeriensis N67유전체 서열, 전사체 및 설치류 말라리아 기생충 Plasmodium yoelii nigeriensis N67의 주석Research Article Published on 2021-04-262024-08-08 Journal: BMC Genomics [Category] 말라리아, [키워드] DNA sequence mouse Plasmodium polymorphism proteome transcript [DOI] 10.1186/s12864-021-07555-9 PMC 바로가기 [Article Type] Research Article
Application of Tensor Decomposition to Gene Expression of Infection of Mouse Hepatitis Virus Can Identify Critical Human Genes and Efffective Drugs for SARS-CoV-2 InfectionArticle Published on 2021-04-232022-10-30 Journal: Ieee Journal of Selected Topics in Signal Processing [Category] COVID-19, [키워드] in silico drug discovery antiviral drugs application applied approach Can candidate drug caused Compound coronavirus Coronavirus infection COVID-19 Critical database dataset decomposition domain drug expression Feature extraction gene expression profile Genes Human identify in silico Infection Infectious disease liver mouse mouse hepatitis virus Novel coronavirus polyprotein protease protein-protein interaction SARS-CoV-2 screened selected spleen Tensor tensor decomposition treating COVID-19 [DOI] 10.1109/JSTSP.2021.3061251 PMC 바로가기 [Article Type] Article
Recombinant Human Thymosin Beta-4 Protects against Mouse Coronavirus InfectionResearch Article Published on 2021-04-212022-10-31 Journal: Mediators of Inflammation [Category] COVID-19, MERS, [키워드] acetylated Actin activity acute respiratory syndrome Angiogenesis Anti-inflammatory antioxidant BALB/c conducted coronavirus Coronavirus infection COVID-19 CoVs disease evaluate experiment expressed function Host Human human CoV human tissues humans immune response infect inhibiting linear liver MERS MERS-CoV MHV MHV-A59 mice Middle East mouse mouse CoV mouse hepatitis virus N-terminus pathogenic coronavirus peptide promoter protective effect recombinant regulate required RNA genome SARS-CoV SARS-CoV-2 significantly increased survival rate syndrome treat Treatment viral pathogenesis virus replication wound healing [DOI] 10.1155/2021/9979032 PMC 바로가기 [Article Type] Research Article
Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry비교 분석을 통해 SARS-CoV-2 진입에 필요한 ACE2의 종별 유전적 결정인자가 밝혀졌습니다.Research Article Published on 2021-03-242022-08-13 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 protein ACE2 proteins ACE2 sequence animal model binding can not cell entry cellular receptor Comparative analysis coronavirus Critical facilitate functional Genetic genetic determinant genetic determinants genetic engineering host cell host range Human human ACE2 Interaction koala limit mammalian mouse New World New World monkey receptor receptor function replaced REPLACED BY required residue restored restrict reveal SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike protein sequences shown Spike protein Support the spike protein Thr tissue tropism Viral viral entry viral spike protein [DOI] 10.1371/journal.ppat.1009392 PMC 바로가기 [Article Type] Research Article
Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria질병 내성의 유도 메커니즘은 말라리아에 대한 획득 면역의 대안 전략을 제공합니다.Article Published on 2021-03-232024-08-08 Journal: eLife [Category] 말라리아, [키워드] disease tolerance innate memory macrophages malaria Monocytes mouse Other tissue niche [DOI] 10.7554/eLife.63838 PMC 바로가기
Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infectionIFN-γ에 대한 상피 반응은 SARS-CoV-2 감염을 촉진합니다Report Published on 2021-03-032022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 expression Affect agent angiotensin Antiviral cause cell differentiation cellular cellular differentiation characterized Colon colonic COVID‐19 Culture differentiation disease elevated Enterocyte enterocytes epithelial epithelial cell epithelial cells expressed expressing gastrointestinal mucosa IFN‐γ immune response immune responses immunology induce Inducing inefficient infected cells Infection Inflammation Inflammatory response interferon interferon signaling KRT20 maturation mechanism mediator Microbiology, Virology & Host Pathogen Interaction mouse Organoid organoids outcome patients promote promoted receptor Replication respiratory response robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Severe case severe cases subset susceptibility susceptibility to infection Treatment virus clearance virus production virus replication virus transmission [DOI] 10.15252/emmm.202013191 PMC 바로가기 [Article Type] Report