Reduced neutralizing antibody potency of COVID-19 convalescent vaccinated plasma against SARS-CoV-2 Omicron variantSARS-CoV-2 오미크론 변이체에 대한 COVID-19 회복기 백신 접종 혈장의 중화 항체 효능 감소Article Published on 2022-07-012022-09-11 Journal: Vox Sanguinis [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] anti-IgG Anti-S1 antibody assays B.1 best binding coefficient collected convalescent convalescent plasma correlated correlation coefficient COVID-19 D614G Donor fraction highest IgG IgG level Immunocompromised patient Immunocompromised patients Infection median Mutation NAb Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Omicron variant plasma Quantitative reduced relationship resulting SARS-CoV-2 selected significantly lower Spearman Strains threshold titre titres vaccination variant [DOI] 10.1111/vox.13279 PMC 바로가기 [Article Type] Article
Heterogeneity assessment of vaccine-induced effects using point-of-care surrogate neutralization test for severe acute respiratory syndrome coronavirus 2중증급성호흡기증후군 코로나바이러스 2에 대한 현장 진료 대리 중화 시험을 이용한 백신 유발 효과의 이질성 평가Article Published on 2022-07-012022-09-12 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome analyzed association caused collected coronavirus correlated COVID-19 declined disease Effect Efficacy ELISA first dose global pandemic gold standard healthcare worker heterogeneity identify IgG IgM/IgG immunochromatography immunological Isolation neutralization Neutralization antibody Neutralizing Neutralizing activity of BNT162b2 peaked POCT point-of-care receiving reduction S-RBD SARS-CoV-2 serum sample sVNT vaccination Vaccine virus neutralization test [DOI] 10.1002/jcla.24545 PMC 바로가기 [Article Type] Article
Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2 Research Published on 2022-06-302022-10-05 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 animal models antibody Antiviral antivirals bind conserved convalescent patient coronavirus COVID-19 epitope functional fusion peptide HCoV-OC43 Infection mechanism membrane fusion murine Neutralizing activity observation outbreak peptide postfusion prefusion Prophylactic reactivity S2’ site SARS-CoV-2 spike trimer target the SARS-CoV-2 the spike protein therapeutic unique Vaccine variants viral entry β-Coronaviruses [DOI] 10.1038/s41564-022-01155-3 [Article Type] Research
Potency of Fusion-Inhibitory Lipopeptides against SARS-CoV-2 Variants of Concern우려되는 SARS-CoV-2 변이체에 대한 융합 억제 리포펩티드의 효능Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] affected antibodies antiviral efficacy Beta causative agent concern conformational conserved convalescent COVID-19 cross-protective described dimeric doses effective Efficacy elicited evade expected ferret ferrets FIVE Frequency fusion inhibitor Immunity in vitro in vivo Infection Intervention less lipopeptide mechanism of action monoclonal antibody monoclonal antibody therapy monomeric neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody peptide peptides postvaccination postvaccine sera potency Protein Receptor binding Receptor-binding domain reported resulting S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 transmission SARS-CoV-2 variant selective selective pressure selective pressures sera Seven shown spike Spike protein Spread strain the receptor-binding domain therapeutic therapy vaccination Vaccine variant Viral viral entry viral evolution viral infection virus virus neutralization assays VoC VOCs Waves [DOI] 10.1128/mbio.01249-22 PMC 바로가기 [Article Type] Article
Immune Responses Against SARS-CoV-2 WT and Delta Variant in Elderly BNT162b2 Vaccinees노인 BNT162b2 백신의 SARS-CoV-2 WT 및 Delta 변이체에 대한 면역 반응Article Published on 2022-06-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Against age Age-dependent immune responses after BNT162b2 analyzed antibody Antibody titer Antibody titers B.1.617.2 Blood BNT162b2 booster cellular cohorts coronavirus COVID-19 Delta delta variant elderly ELISPOT group groups highlighting humoral immune response IFNγ IgG titers immune response immune responses Immunoglobulin Immunoglobulin G mononuclear cell mononuclear cells neutralization ability neutralization activities neutralization activity neutralization titer neutralization titers Neutralizing Neutralizing activity Neutralizing antibodies nursing homes overcome pandemic participant peripheral Peripheral blood Peripheral blood mononuclear cells resident response rising SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 spike protein SARS-CoV-2 vaccination SARS-CoV-2 WT second vaccination significantly increased specific antibodies Spike protein syndrome T cell T cell immunity T cell response vaccination vaccine dose vaccinee vaccinees Vaccines variants variants of concern variants of concern (VOCs) variants of SARS-CoV-2 Virus neutralization VOCs wild-type [DOI] 10.3389/fimmu.2022.868361 PMC 바로가기 [Article Type] Article
Efficacy of Licensed Monoclonal Antibodies and Antiviral Agents against the SARS-CoV-2 Omicron Sublineages BA.1 and BA.2SARS-CoV-2 오미크론 하위 계통 BA.1 및 BA.2에 대한 허가된 단일 클론 항체 및 항바이러스제의 효능Article Published on 2022-06-232022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] active against agent Antiviral antiviral drugs assays B.1 bamlanivimab Casirivimab cell-based assay Concentration Cytopathic effect defined drug activity etesevimab Evolution of SARS-CoV-2 Ex vivo Imdevimab individual Lineage lineages Live virus mAb mAbs microneutralization Microneutralization assay molnupiravir monoclonal antibodies monoclonal antibody neutralized Neutralizing activity Nirmatrelvir omicron omicron sublineages remained Remdesivir SARS-CoV-2 SARS-CoV-2 variant sera serum dilution SOT Sotrovimab the SARS-CoV-2 treated wild-type [DOI] 10.3390/v14071374 PMC 바로가기 [Article Type] Article
mRNA vaccine boosting enhances antibody responses against SARS-CoV-2 Omicron variant in individuals with antibody deficiency syndromesmRNA 백신 부스팅은 항체 결핍 증후군이 있는 개인에서 SARS-CoV-2 Omicron 변이체에 대한 항체 반응을 향상시킵니다Article Published on 2022-06-212022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-spike antibody antibody deficiency syndrome Antibody Response Antibody titer Antibody titers binding combined variable antibody deficiency comparable coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 deficiency Delta develop domain ENhance Fcγ receptor FcγR healthy donors humoral immune response Hypogammaglobulinemia immune immune response immune responses Immunity immunization Immunoglobulin immunoglobulin replacement therapy individual MOST mRNA mRNA vaccination mRNA vaccine mRNA vaccines neutralization neutralizing activities Neutralizing activity neutralizing antibody titers omicron primary antibody Protective RBD receptor replacement therapy respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants serum severe acute respiratory syndrome Coronavirus specific antibody deficiency sustained syndrome tested titers vaccinated individual vaccination Vaccine variant virus [DOI] 10.1016/j.xcrm.2022.100653 PMC 바로가기 [Article Type] Article
Salivary, serological, and cellular immune response to the CoronaVac vaccine in health care workers with or without previous COVID-19이전 COVID-19 유무에 관계없이 의료 종사자의 CoronaVac 백신에 대한 타액, 혈청 및 세포 면역 반응Article Published on 2022-06-162022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] analysed anti-SARS-CoV-2 antibodies Cellular immune response chemiluminescence CoronaVac COVID-19 Delta dose ELISA evaluated Evidence flow cytometry Gamma Health care Health care worker health care workers IFN-γ IFN-γ producing T cells IgA IgG anti-spike antibody IgG antibodies IgG antibody immunized inactivated individual individuals induce infected individuals interferon investigated neutralization test Neutralizing activity post-vaccine response producing provide reactive reduced reference strain response Saliva salivary SARS-CoV-2 SARS-CoV-2 variant serological serum serum antibodies serum antibody specific serum Spike protein T cell T cells T-cell the spike protein uninfected vaccinated individual vaccinated individuals Vaccine variable variants virus virus neutralization test [DOI] 10.1038/s41598-022-14283-x PMC 바로가기 [Article Type] Article
IgG Anti-Spike Antibodies and Surrogate Neutralizing Antibody Levels Decline Faster 3 to 10 Months After BNT162b2 Vaccination Than After SARS-CoV-2 Infection in Healthcare WorkersIgG 항스파이크 항체 및 대리 중화 항체 수준은 의료 종사자의 SARS-CoV-2 감염 후보다 BNT162b2 백신 접종 후 3~10개월 더 빠르게 감소합니다Article Published on 2022-06-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE-2 anti-S Anti-spike antibody Antibody titers Beta Beta variant binding BNT162b2 Cohort concern COVD-19 COVD-19 serological testing COVID-19 Decline dose expressed faster HCW Health care Health care worker health care workers highest humoral immune response hybrid IgG Immunity Infection Level linear linear relationship Live virus Month natural infection neutralization Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers of BNT162b2 omicron predicted Randomly ranged reduced resulting SARS-CoV-2 SARS-COV-2 infection selected sensitivity serological Serological testing spike surrogate the strongest Type vaccination variant VoC wild type worker [DOI] 10.3389/fimmu.2022.909910 PMC 바로가기 [Article Type] Article
Intranasal immunization with a proteosome-adjuvanted SARS-CoV-2 spike protein-based vaccine is immunogenic and efficacious in mice and hamsters프로테오솜 보조제가 첨가된 SARS-CoV-2 스파이크 단백질 기반 백신을 사용한 비강내 면역은 마우스와 햄스터에서 면역원성과 효능이 있습니다.Article Published on 2022-06-132022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition Antigen B.1.351 B.1.617.2 Beta binding Blood body weight Body weight loss cellular Delta disease evaluated Formulation hamster help IgA titers IgG immune responses immunization immunogenic intranasal Lungs mice mucosal mucosal surface Neutralizing activity offer pandemic persistence prefusion Prevent profile protective immune response Protein protein subunit vaccine reduce reducing reference strain resistin robust SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic SARS-CoV-2 spike SARS-CoV-2 vaccine serum antibodies serum antibody spike Spike protein Subunit vaccine the SARS-CoV-2 Vaccine variants variants of concern Viral viral entry Viral load viral spike protein weight loss [DOI] 10.1038/s41598-022-13819-5 PMC 바로가기 [Article Type] Article