NLRP3 inflammasome

[키워드] activated Activation Acute inflammation ameliorated appear association benefit blocking cascade cause CD45 characterized clinical complex component Control deficiency Deletion disease Disease progression exacerbated excessive inflammation exhibited experiment expression Fgl2 fulminant Gr-1 Hepatic encephalopathy Hepatitis hepatocyte high mortality Host IL-1β inefficient Infection Inflammasome Inflammatory Inflammatory diseases Inflammatory response Intervention knowledge lack life-threatening limit liver Macrophage macrophages Mediated mice Mortality murine hepatitis virus NADPH Necrosis neutrophil neutrophil infiltration nicotinamide adenine dinucleotide NLRP3 NLRP3 inflammasome pathogen invasion Pathogenesis pathway phosphate Prevent Protein reactive oxygen specy recruitment reduce reduced reduction in reductions in Resilience responsible resulting ROS ROS production secretion serum severe disease severe liver disease Signaling signaling pathway subsequent subunit syndrome the disease treated Treatment viral infection virus infection virus replication wild-type
[DOI] 10.1371/journal.ppat.1005155 PMC 바로가기 [Article Type] Research Article